Clinical value of systemic immunoinflammatory index in predicting recurrence and metastasis in patients with primary liver cancer.

Background: Primary liver cancer is a highly aggressive neoplasm with high incidence and mortality. Due to the high ability to metastasis, the 5-year survival rate of patients with primary liver cancer is poor.

Aim: To investigate the clinical value of systemic immunoinflammatory index (SII) in predicting recurrence and metastasis after interventional therapy in patients with primary liver cancer.

Plasma microRNA-30a expression in patients with chronic hepatitis B and its application value in the assessment of the severity of liver fibrosis.

Objective: The severity of liver fibrosis (LF) in chronic hepatitis B (CHB) affects the outcome and treatment. We probed plasma miR-30a expression in CHB patients and its value in assessing LF severity.

Methods: This retrospective study included 160 CHB patients and another 98 controls.

In-situ silver (Ag) clusters strengthed spatial separation of photogenerated charge-carriers for efficient photocatalytic tetracycline antibiotic purification.

Metal cluster co-catalysts have been widely considered as an effective strategy to address the energy crisis and environmental problems owning to the efficient light absorption and the enhanced separation of electron hole pairs. In this contribution, via a facile in-situ photoreduction technique, the Ag/(BiO)CO composites were synthesized to degrade the antibiotic pollutant tetracycline (TC). The incorporation of silver (Ag) clusters on (BiO)CO surface can form the built-in electric field (IEF) at the Mott-Schottky junction interface and facilitate the migration of photo-generated electrons from (BiO)CO to Ag clusters.

Physiological and Neuromuscular Fatigue after 3-Minute Lateral Shuffle Movement at Different Speeds and Distances.

This study aimed to 1) investigate and compare physiological and neuromuscular fatigue after a 3-min lateral shuffle movement (LSM) at different speeds and distances, and 2) examine the relationship between the number of changes of direction (CODs) during LSM and fatigue-related variables. Twenty male college athletes (age: 20.9 ± 1.

Validity of Three Commercial Devices for Recording Movement Velocity in the Bulgarian Split Squat.

This study aimed to assess the validity of three commercial devices in recording mean velocity (MV) and peak velocity (PV) during a unilateral resistance exercise. Eighteen strength-trained and healthy males performed repetitions of Bulgarian split squats at loads ranging from 40% to 90% of their one-repetition maximum. MV and PV were simultaneously recorded by GymAware, PUSH, My Lift and compared to Vicon for all repetitions.

Test-Retest Reliability and Sensitivity of Kinematic and Kinetic Metrics Measured from Horizontal Deceleration Ability Tests with Different Sprinting Distances.

This study aimed to (1) assess the test-retest reliability and sensitivity of kinematic and kinetic metrics from 5-m, 10-m, and 20-m horizontal deceleration ability (HDA) tests; (2) explore the relationships of those metrics from HDA5m, HDA10m and HDA20m tests. Eighteen college athletes completed one familiarization session and two test sessions separated by 48 hours. Test sessions consisted of three 5-m, 10-m, and two 20-m maximal sprints, along with HDA tests conducted at the same sprinting distances.

Fast Registration Algorithm for Laser Point Cloud Based on 3D-SIFT Features.

In response to the issues of slow convergence and the tendency to fall into local optima in traditional iterative closest point (ICP) point cloud registration algorithms, this study presents a fast registration algorithm for laser point clouds based on 3D scale-invariant feature transform (3D-SIFT) feature extraction. First, feature points are preliminarily extracted using a normal vector threshold; then, more high-quality feature points are extracted using the 3D-SIFT algorithm, effectively reducing the number of point cloud registrations. Based on the extracted feature points, a coarse registration of the point cloud is performed using the fast point feature histogram (FPFH) descriptor combined with the sample consensus initial alignment (SAC-IA) algorithm, followed by fine registration using the point-to-plane ICP algorithm with a symmetric target function.

Elucidating the Mechanism of VVTT Infection Through Machine Learning and Transcriptome Analysis.

The vaccinia virus (VV) is extensively utilized as a vaccine vector in the treatment of various infectious diseases, cardiovascular diseases, immunodeficiencies, and cancers. The vaccinia virus Tiantan strain (VVTT) has been instrumental as an irreplaceable vaccine strain in the eradication of smallpox in China; however, it still presents significant adverse toxic effects. After the WHO recommended that routine smallpox vaccination be discontinued, the Chinese government stopped the national smallpox vaccination program in 1981.

Relationships between knee and ankle strength and horizontal deceleration performance at different sprint distances in multi-directional sports athletes.

The aim of this study was to investigate the relationships between knee and ankle strength and horizontal deceleration performance following different sprint distances. Fifty-seven ( = 41male,  = 16 female) youth team-sports athletes completed: a) 5-m and 10-m horizontal deceleration ability (HDA) tests; b) concentric (60°/s, 180°/s) and eccentric (30°/s) relative peak torque (PT) measurements of the knee extensor (KE) and flexor (KF) muscles and the ankle plantarflexion (APF) and dorsiflexion (ADF) muscles in an isokinetic dynamometer. Pearson's correlation coefficients revealed that concentric at 60°/s and eccentric at 30°/s KE were mostly related to deceleration performance both in HDA ( = -0.

Identification of Lighting Strike Damage and Prediction of Residual Strength of Carbon Fiber-Reinforced Polymer Laminates Using a Machine Learning Approach.

Due to the complex and uncertain physics of lightning strike on carbon fiber-reinforced polymer (CFRP) laminates, conventional numerical simulation methods for assessing the residual strength of lightning-damaged CFRP laminates are highly time-consuming and far from pretty. To overcome these challenges, this study proposes a new prediction method for the residual strength of CFRP laminates based on machine learning. A diverse dataset is acquired and augmented from photographs of lightning strike damage areas, C-scan images, mechanical performance data, layup details, and lightning current parameters.

Associations between CAG repeat size, brain and spinal cord volume loss, and motor symptoms in spinocerebellar ataxia type 3: a cohort study.

Background: Spinocerebellar ataxia type 3 (SCA3) is a hereditary disease caused by abnormally expanded CAG repeats in the ATXN3 gene. The study aimed to identify potential biomarkers for assessing therapeutic efficacy by investigating the associations between expanded CAG repeat size, brain and spinal cord volume loss, and motor functions in patients with SCA3.

Methods: In this prospective, cross-observational study, we analyzed 3D T1-weighted MRIs from 92 patients with SCA3 and 42 healthy controls using voxel-based morphometry and region of interest approaches.

A mobile-based multidomain lifestyle intervention using Cognitive Evergreenland for older adults with subjective cognitive decline: a feasibility study.

Background: Dementia is a growing public health issue. Non-drug interventions targeting individuals before the onset of overt cognitive decline may be effective. Subjective cognitive decline (SCD) is present in > 50% of older adults and associated with progression to dementia.

Regional adipose distribution and metabolically unhealthy phenotype in Chinese adults: evidence from China National Health Survey.

Background: The mechanisms distinguishing metabolically healthy from unhealthy phenotypes within the same BMI categories remain unclear. This study aimed to investigate the associations between regional fat distribution and metabolically unhealthy phenotypes in Chinese adults across different BMI categories.

Methods: This cross-sectional study involving 11833 Chinese adults aged 20 years and older.

Optimizing Yeast Homologous Recombination for Splicing Large Coronavirus Genome Fragments.

Reverse genetics is a useful tool for studying viruses and developing vaccines for coronaviruses. However, constructing and manipulating the coronavirus genome in can be time-consuming and challenging due to its large size and instability. Homologous recombination, a genetic manipulation mechanism found in organisms, is essential for DNA repair, gene recombination, and genetic engineering.

Isotonic medium treatment limits burn wound microbial colonisation and improves tissue repair.

Burn injuries undergo a complex healing process in which progressive spreading of epithelial damage can lead to secondary complications such as wound infection, which is a major driver of mortality among burn patients. We recently reported that burning larval zebrafish triggers dysregulated keratinocyte dynamics compared to mechanical injury. Here, we investigate keratinocyte behaviour following burn injury and the subsequent potential for microbial colonisation of burn wounds over time.

Optimal Frequency of Interrupting Prolonged Sitting for Cardiometabolic Health: A Systematic Review and Meta-Analysis of Randomized Crossover Trials.

Increasing evidence highlights the efficacy of interruptions in prolonged sitting (i.e., activity/sedentary breaks) for improving cardiometabolic health, but precise conclusions and recommendations regarding the optimal interruption frequency remain poorly defined.

Uricase-Expressing Engineered Macrophages Alleviate Murine Hyperuricemia.

: Uricase, or urate oxidase (Uox) is a key enzyme in uric acid (UA) metabolism and has been applied in clinical treatment of human hyperuricemia (HUA). However, the current clinically applied uricases, despite their potent urate-lowering capacity, tend to form anti-drug antibodies because of their immunogenicity, leading to increased risk of anaphylaxis, faster drug clearance and reduced or even complete loss of therapeutic effect, limiting their clinical application. In this study, we constructed engineered macrophages that stably expressed uricase, which might serve as a promising alternative to the direct injection of uricases.

Effects of Integrating Stair Climbing-Based Exercise Snacks Into the Campus on Feasibility, Perceived Efficacy, and Participation Perspectives in Inactive Young Adults: A Randomized Mixed-Methods Pilot Study.

This 6-week pilot study aimed to investigate the feasibility, perceived efficacy, and participation perspectives of a university campus stair climbing-based exercise snack (ES) intervention and to compare it to moderate-intensity continuous training (MICT). Healthy, young, inactive adults (age: 21.6 ± 2.

Monitoring of spore-forming dynamics through flow cytometry.

The plate counting method is a traditional and widely accepted technique for live cell counting, often employed for enumeration and spore forming rate calculations. However, this method requires at least 12 h to generate results, making it unsuitable for real-time monitoring of bacterial growth status and spore transformation rate. crystals, produced during sporulation, are widely used as microbial pesticides, with high demand for industrial scale production.

Demonstration of MAX phases as triple functional artificial solid electrolyte interphase for ultralong life lithium metal anodes.

Solid electrolyte interphase (SEI) has significant role in controlling lithium (Li) dendrites. However, lack of chemical stability, mechanical strength and self-perfection for conventional SEI cannot persistently suppress Li dendrites, leading to inferior cycling life. Herein, MAX phases (TiSnC and TiSC) as triple functional artificial SEI (ASEI) with high modulus, chemical stability and self-smoothing ability are introduced on Li foils (TiSnC@Li and TiSC@Li) for ultralong life Li metal anodes (LMAs).

Parthenolide attenuates hypoxia-induced pulmonary hypertension through inhibiting STAT3 signaling.

Background: Pulmonary hypertension (PH) is a chronic lung disease characterized by the progressive pulmonary vascular remodeling with increased pulmonary arterial pressure and right ventricular failure. Pulmonary vascular remodeling involves the proliferation, migration, and resistance to apoptosis of pulmonary artery smooth cells (PASMCs). Parthenolide (PTN) is a bioactive compound derived from a traditional medical plant feverfew (Tanacetum parthenium), and it has been studied for treatment of pulmonary fibrosis, lung cancer, and other related ailments.

Sex-specific associations between total and regional Fat-to-muscle Mass ratio and cardiometabolic risk: findings from the China National Health Survey.

Background: The fat-to-muscle mass ratio (FMR), integrating the antagonistic effects of fat and muscle mass, has been suggested as a valuable indicator to assess cardiometabolic health independent of overall adiposity. However, the specific associations of total and regional FMR with cardiometabolic risk are poorly understood. We aimed to examine sex-specific associations of total and regional FMR with single and clustered cardiometabolic risk factors (CRFs).