Real-world analysis of medications inducing meibomian gland dysfunction: based on the FDA adverse event reporting system database.

Background: Dry eye syndrome (DES) significantly affects quality of life. Meibomian Gland Dysfunction (MGD) is a primary contributor to DES and may be drug-induced.

Research Design And Methods: This study analyzed data from the FDA Adverse Event Reporting System (FAERS) between January 2004 and September 2023 using the Ratio of Odds Ratios (ROR) and Proportional Reporting Ratio (PRR) to detect potential drug-induced MGD signals.

Association between systemic immune inflammation index and cataract incidence from 2005 to 2008.

The objective of this study is to investigate the association between the Systemic Immune-Inflammation Index (SII) and cataracts. This cross-sectional study analyzed data from the 2005-2008 NHANES to examine the relationship between the SII and cataract prevalence. Covariates included age, race/ethnicity, gender, education level, marital status, Body Mass Index (BMI), smoking, alcohol consumption, hypertension, hyperlipidemia, and diabetes.

Measurement and characterization of internal delamination defects in CFRP based on line laser thermography frequency domain analysis.

Carbon fiber reinforced polymers (CFRPs) are widely used in fields such as aviation and aerospace. However, subtle defects can significantly impact the material's service life, making defect detection a critical priority. In this paper, delamination defects in CFRP are detected using line laser infrared thermography, and a defect characterization algorithm that combines differential thermography with a frequency-domain filter is proposed.

Media multitasking enhances individuals' anticipatory brain functions.

Media multitasking has become pervasive in our daily lives, yet its impact on cognitive abilities remains contentious, with more evidence supporting adverse effects (scattered attention hypothesis) than benefits (trained attention hypothesis). Recent studies have increasingly focused on the training effects of behavioral training on anticipatory brain functions, which involve cognitive and motor preparation before stimulus onset, assessed using event-related potentials (ERPs). This study investigated whether media multitasking enhances anticipatory brain functions and how task difficulty influences this relationship.

DDoCT: Morphology preserved dual-domain joint optimization for fast sparse-view low-dose CT imaging.

Computed tomography (CT) is continuously becoming a valuable diagnostic technique in clinical practice. However, the radiation dose exposure in the CT scanning process is a public health concern. Within medical diagnoses, mitigating the radiation risk to patients can be achieved by reducing the radiation dose through adjustments in tube current and/or the number of projections.

An Organic EnT Photocatalyst 4CzMeBN and the Application in the Synthesis of cis-Fused Azetidines.

A powerful EnT photocatalyst 4CzMeBN has been developed and utilized in the synthesis of cis-fused azetidines via dearomative [2+2] cycloaddition under visible light. The photocatalyst 4CzMeBN is a donor-acceptor cyanoarene and features high triplet state energy and long lifetime of triplet state, which would be an alternative to widely used EnT photocatalyst Ir[dF(CF)ppy](dtbbpy)PF. The photochemical [2+2] cycloaddition provides a facile method to synthesize valuable dihydroisoquinolone-fused azetidines with high efficiency.

A functional hydrogel dressing based on glycyrrhizic acid with low-swelling and moisturizing properties for enhancing infected wound repair.

Wound healing is a challenging due to the presence of bacterial infection, excessive inflammation and angiogenesis disorders. While traditional therapies struggle, a functional hydrogel can effectively repair wounds. However, the use of hydrogels is limited due to their high swelling and excessive dehydration characteristics.

Pro-inflammatory diet and risk of prostate diseases, lower urinary tract symptoms: A cross-sectional study from the National Health and Nutrition Examination Survey (NHANES) 2003 to 2008.

Evidence suggests a strong association between prostate diseases, lower urinary tract symptoms (LUTS), and pro-inflammatory diets. Our study was conducted to assess the relationship between the Dietary Inflammatory Index (DII) and prostate diseases, LUTS using the 2003 to 2008 U.S.

Age and sex-related differences in elastic properties of the gastrocnemius muscle-tendon unit: an observational prospective study.

Introduction: Changes in the mechanical properties of the gastrocnemius muscle-tendon unit can lead to abnormal biomechanics of lower limbs, which is a risk factor for the development of many diseases. However, fewer studies have explored physiological changes in the gastrocnemius muscle-tendon unit stiffness. This study aimed to investigate the age- and sex-related differences in the gastrocnemius muscle-tendon unit stiffness.

UV-visible-infrared light driven photothermal synergistic catalytic reduction of CO over CsBiBr/MoS S-scheme photocatalyst.

Photothermocatalytic CO reduction has been considered as a green and sustainable strategy for solar-to-fuel conversion, since it can utilize the solar energy to simultaneously provide heat input and produce photogenerated charge carriers. To this end, exploring photothermal catalysts with broad-band absorption, high photo-heat conversion and charge separation efficiency is highly desirable. In this work, an innovative CsBiBr/MoS (CBB/MoS) composite has been elaborately constructed to investigate the photothermocatalytic performance towards CO reduction.

Ocular adverse events associated with GLP-1 receptor agonists: a real-world study based on the FAERS database and network pharmacology.

Objective: This study evaluates the risk of ocular adverse events (AEs) associated with glucagon-like peptide-1 receptor agonists (GLP-1 RAs) using data from the FDA Adverse Event Reporting System (FAERS) and network pharmacology methods.

Methods: FAERS data from 2004 to 2024 were analyzed for ocular AEs linked to GLP-1 RA treatments. Disproportionality analysis (Reporting Odds Ratio, ROR) was used to identify signals, and a drug-gene interaction network explored potential mechanisms.

Enhancing Coffee Agroforestry Systems Suitability Using Geospatial Analysis and Sentinel Satellite Data in Gedeo Zone, Ethiopia.

The Gedeo zone agroforestry systems are the main source of Ethiopia's coffee beans. However, land-use and suitability analyses are not well documented due to complex topography, heterogeneous agroforestry, and lack of information. This research aimed to map the coffee coverage and identify land suitability for coffee plantations using remote sensing, Geographic Information Systems (GIS), and the Analytical Hierarchy Process (AHP) in the Gedeo zone, Southern Ethiopia.

Platelet Proteomics and Tissue Metabolomics Investigation for the Mechanism of Aspirin Eugenol Ester on Preventive Thrombosis Mechanism in a Rat Thrombosis Model.

Platelet activation is closely related to thrombosis. Aspirin eugenol ester (AEE) is a novel medicinal compound synthesized by esterifying aspirin with eugenol using the pro-drug principle. Pharmacological and pharmacodynamic experiments showed that AEE has excellent anti-inflammatory, antioxidant, and inhibitory platelet activation effects, preventing thrombosis.

Magnetic navigation-assisted colonoscopic enteral tube placement in swine (with video): a preliminary study.

Background: Colonoscopic enteral tube placement using current methods has some shortcomings, such as the complexity of the procedure and tube dislodgement. The magnetic navigation technique (MNT) has been proven effective for nasoenteral feeding tube placement, and is associated with reduced cost and time to initiation of nutrition. This study attempted to develop a novel method for enteral tube placement using MNT.

The correlation between social support, coping style, advance care planning readiness, and quality of life in patients with amyotrophic lateral sclerosis: a cross-sectional study.

Objective: The primary goal for clinical healthcare professionals is to enhance the quality of life (QOL) of patients with amyotrophic lateral sclerosis (ALS). This study aimed to explore the correlation between social support, coping style, advance care planning (ACP) readiness, and QOL in patients with ALS. We also sought to analyze the mediating effect of coping style and ACP readiness between social support and QOL, and to provide insights for developing targeted interventions to improve patients' QOL.

The Asymmetrical Fe-O-Se Bonds in FeO(SeO) Boosting Bifunctional Oxygen Electrocatalytic Performance for Zinc-Air Battery.

Zinc-air batteries (ZABs) have the advantages of high energy density and rich zinc raw materials. It is a low-cost, green and sustainable energy storage device. At present, one of the key technologies that hinder the large-scale application of ZABs is the design and fabrication oxygen evolution reaction (OER) and oxygen reduction reaction (ORR) bifunctional catalysts with excellent performance, especially the non-platinum-based catalysts.

Effects of central intermittent theta-burst stimulation combined with repetitive peripheral magnetic stimulation on upper limb function in stroke patients.

Background: Intermittent theta-burst stimulation and repetitive peripheral magnetic stimulation can improve motor function in poststroke patients, but the therapeutic effect of this combination remains unclear.

Objective: To determine the effects of central intermittent theta-burst stimulation and repetitive peripheral magnetic stimulation on upper limb function.

Methods: Fifty-six subacute stroke patients were randomly assigned to three groups: the CMS (n = 18), peripheral magnetic stimulation (PMS) (n = 19) and CPS (n = 19) groups.