The dynamic effects of nutritional status on chemotherapy-related toxicity in patients with non-Hodgkin's lymphoma.

Background/objectives: Understanding the dynamic changes in nutritional status of patients with non-Hodgkin's lymphoma (NHL) during chemotherapy is crucial, as it significantly impacts chemotherapy-related toxicity and survival outcomes.

Subjects/methods: This multi-center study included newly diagnosed NHL patients. Nutritional status and chemotherapy-related toxic effects were assessed over the first five chemotherapy sessions, with follow-ups conducted every 3 months.

A molecularly imprinted ratio fluorescence sensor based on metal-enhanced fluorescence of core-shell structure CaF-silver nanoparticle for visual detection of dicamba.

Although fluorescence analysis methods are widely used in pesticide residue detection, improving their sensitivity and selectivity remains a challenge. This paper presents a novel ratio fluorescence sensor based on the molecular imprinting polymers (MIPs) and metal-enhanced fluorescence for visual detection of dicamba (DIC). Calcium fluoride (CaF) quantum dots (QDs) were immobilized on the surface of Ag@MIPs, resulting in a blue fluorescence response signal (Ag@MIPs-CaF).

Nanodrug delivery system constructed with dopamine-based functional molecules for efficient targeting of tumour cells.

In order to enhance the water solubility of chemotherapeutic drugs, improve their biodistribution and narrow therapeutic window, two molecules of PDAO and FA-DAO with acid-sensitive Schiff base structure were designed and synthesized based on dopamine linolenate (DAO) in this paper, and subsequently drug-loaded nanoparticles were prepared by simply mixing of them with curcumin (Cur) in aqueous solution. These nanoparticles can release a large amount of the drug in response to pH changes in the tumor microenvironment through passive targeting. The cumulative rate of drug release can reach up to 70% within 24 hours under pH = 5.

An FPGA-Based YOLOv5 Accelerator for Real-Time Industrial Vision Applications.

The You Only Look Once (YOLO) object detection network has garnered widespread adoption in various industries, owing to its superior inference speed and robust detection capabilities. This model has proven invaluable in automating production processes such as material processing, machining, and quality inspection. However, as market competition intensifies, there is a constant demand for higher detection speed and accuracy.

Neutrophil Extracellular Traps-Inspired Bismuth-Based Polypeptide Nanonets for Synergetic Treatment of Bacterial Infections.

Excessive use of antibiotics and the formation of bacterial biofilms can lead to persistent infections caused by drug-resistant bacteria, rendering ineffective immune responses and even life-threatening. There is an urgent need to explore synergistic antibacterial therapies across all stages of infection. Drawing inspiration from the antibacterial properties of neutrophil extracellular traps (NETs) and integrating the bacterial biofilm dispersal mechanism involving boronic acid-catechol interaction, the multifunctional bismuth-based polypeptide nanonets (PLBA-Bi-Fe-TA) are developed.

Enantioselective liquid-liquid extraction of 2-cyclohexylmandelic acid enantiomers using chiral ionic liquids.

Obtaining optically pure compounds in an eco-friendly and cost-efficient manner plays an important role in human health and pharmaceutical industry. Racemic separation using multistage stereoselective liquid-liquid extraction has become one of the most practical and effective approach to access homochiral enantiomers. Currently, chiral ionic liquids (CILs) with structural designability have become a promising chiral additive and enable them as adjustable candidates for racemic separation.

The sources, properties, extraction, biosynthesis, pharmacology, and application of lycopene.

Lycopene is an important pigment with an alkene skeleton from , which is also obtained from some red fruits and vegetables. Lycopene is used in the food field with rich functions and serves in the medical field with multiple clinical values because it has dual functions of both medicine and food. It was found that lycopene was mainly isolated by solvent extraction, ultrasonic-assisted extraction, supercritical fluid extraction, high-intensity pulsed electric field-assisted extraction, enzymatic-assisted extraction, and microwave-assisted extraction.

Lyophilization process optimization and molecular dynamics simulation of mRNA-LNPs for SARS-CoV-2 vaccine.

Some studies have shown that lyophilization significantly improves the stability of mRNA-LNPs and enables long-term storage at 2-8 °C. However, there is little research on the lyophilization process of mRNA-lipid nanoparticles (LNPs). Most previous studies have used empirical lyophilization with only a single lyoprotectant, resulting in low lyophilization efficiency, often requiring 40-100 h.

Synthesis of cell penetrating peptide sterol coupler and its liposome study on S-mRNA.

In order to overcome the current LNP-mRNA delivery system's weakness of poor stability and rapid degradation by nuclease, a novel chol-CGYKK molecule and then the new phospholipid liposome were designed and prepared. A solid phase approach synthesized CGYKK and connected it to cholesterol via a disulfide linker to form the desired chol-CGYKK. Four formulated samples with different proportions of excipients were prepared by freeze-drying cationic liposomes and packaged S-mRNA.

Preparation of COF-coated nickel foam adsorbents for dispersive solid-phase extraction of 16 polycyclic aromatic hydrocarbons from Chinese herbal medicines.

Covalent organic framework coated nickel foam (NF@COF) was prepared as a sorbent for the dispersive solid phase extraction (DSPE) of polycyclic aromatic hydrocarbons (PAHs) from Chinese herbal medicines (CHMs) prior to their determination by gas chromatography-mass spectrometry (GC-MS). The structure and morphology of the as-synthesized NF@COF were characterized by different techniques. Various key parameters affecting the performance of the DSPE method, including the amount of sorbent, desorption solvent, desorption volume and time, extraction time, and sample volume, were investigated.

Grad-MobileNet: A Gradient-Based Unsupervised Learning Method for Laser Welding Surface Defect Classification.

Deep learning technology has advanced rapidly and has started to be applied for the detection of welding defects. In the manufacturing process of power batteries for new energy vehicles, welding defects may occur due to the high directivity, convergence, and penetration of the laser beam. The accuracy of deep learning prediction relies heavily on big data, but balanced big data of welding defects is hard to acquire at the battery production site.

Fatty acid binding protein 1 and fatty acid synthetase over-expression have differential effects on collagen III synthesis and cross-linking in Zongdihua pig primary adipocytes.

The purpose of this study was to determine whether FABP1 and FAS regulate expression of collagen and its crosslinking via lysyl oxidase in isolated adipocytes from Zongdihua pigs. We aimed to identify biochemical processes affecting meat quality using molecular tools to provide a basis for breeding improvement of these animals. We measured expression levels of FABP1 and related genes using qRT-PCR in longissimus dorsi muscle and subcutaneous adipose tissues.

Synthesis of CuO/Ag nanoparticles on exfoliated graphene: application for enhanced electrochemical detection of HO in milk.

In this paper, a novel composite is constructed as a non-enzymatic hydrogen peroxide (HO) sensor by liquid-phase exfoliation method, which is composed of copper oxide, cuprous oxide and silver nanoparticles doped few-layer-graphene (CuO/Ag@FLG). Its surface morphology and composition were characterized by scanning electron microscopy (SEM) and X-ray photo spectroscopy (XPS), and its HO sensing performances include catalytic reduction and quantitative detection were studied with electrochemical methods. Our sensor had a high sensitivity of 174.

Determination of polycyclic aromatic hydrocarbons in Chinese herbal medicines by gas chromatography-mass spectrometry with graphene-functionalized nickel foam.

Graphene-functionalized nickel foam (NF) sorbent materials were prepared and characterized by scanning electron microscopy, Fourier transform infrared spectroscopy, X-ray diffraction, X-ray photoelectron spectroscopy and Thermogravimetric analysis. For the separation and detection of polycyclic aromatic hydrocarbons (PAHs) in five Chinese medicine samples, namely dandelion, fructus aurantii, peppermint, mulberry leaf and embryo chrysanthemum, a method combining dispersive micro-solid phase extraction and gas chromatography-mass spectrometry (GC-MS) was developed. Four conditions affecting the extraction efficiency, such as the type of desorption solvent, the amount of sorbent, the extraction time and the volume of water sample, were optimized.

TIME-Net: Transformer-Integrated Multi-Encoder Network for limited-angle artifact removal in dual-energy CBCT.

Dual-energy cone-beam computed tomography (DE-CBCT) is a promising imaging technique with foreseeable clinical applications. DE-CBCT images acquired with two different spectra can provide material-specific information. Meanwhile, the anatomical consistency and energy-domain correlation result in significant information redundancy, which could be exploited to improve image quality.

mRNA based vaccines provide broad protection against different SARS-CoV-2 variants of concern.

In order to overcome the pandemic of COVID-19, messenger RNA (mRNA)-based vaccine has been extensively researched as a rapid and versatile strategy. Herein, we described the immunogenicity of mRNA-based vaccines for Beta and the most recent Omicron variants. The homologous mRNA-Beta and mRNA-Omicron and heterologous Ad5-nCoV plus mRNA vaccine exhibited high-level cross-reactive neutralization for Beta, original, Delta, and Omicron variants.

Sulfhydryl functionalized carbon quantum dots as a turn-off fluorescent probe for sensitive detection of Hg.

Mercury ion (Hg) is one of the most toxic heavy metal ions and lowering the detection limit of Hg is always a challenge in analytical chemistry and environmental analysis. In this work, sulfhydryl functionalized carbon quantum dots (HS-CQDs) were synthesized through a one-pot hydrothermal method. The obtained HS-CQDs were able to detect mercury ions Hg rapidly and sensitively through fluorescence quenching, which may be ascribed to the formation of nonfluorescent ground-state complexes and electron transfer reaction between HS-CQDs and Hg.

Synthesis of palm sheath derived-porous carbon for selective CO adsorption.

Biomass-derived porous carbons are regarded as the most preferential adsorbents for CO capture due to their well-developed textural properties, tunable porosity and low cost. Herein, novel porous carbons were facilely prepared by activation of palm sheath for the highly selective separation of CO from gas mixtures. The textural features of carbon materials were characterized by the analysis of surface morphology and N isotherms for textural characterization.

A highly selective and sensitive "on-off" fluorescent probe for detecting cadmium ions and l-cysteine based on nitrogen and boron co-doped carbon quantum dots.

Cadmium ions (Cd) have caused relatively serious pollution, threatening human health and ecosystems. l-Cysteine (l-Cys) is an essential amino acid in living organisms and concentration of l-Cys is closely related to some human diseases. In this work, we first introduced 2-amino-3-hydroxypyridine and sodium borohydride as the nitrogen source and boron source to fabricate boron and nitrogen co-doped carbon quantum dots (N,B-CQDs) with high fluorescence quantum yield (21.

Application of artificial intelligence in COVID-19 medical area: a systematic review.

Background: Coronavirus disease 2019 (COVID-19) has caused a large-scale global epidemic, impacting international politics and the economy. At present, there is no particularly effective medicine and treatment plan. Therefore, it is urgent and significant to find new technologies to diagnose early, isolate early, and treat early.

2D leaf-like ZIF-L decorated with multi-walled carbon nanotubes as electrochemical sensing platform for sensitively detecting thiabendazole pesticide residues in fruit samples.

Excessive use of pesticides in modern agriculture results in large amounts of pesticide residues in agricultural production, greatly threatening human health. Herein, novel two-dimensional leaf-like zeolitic imidazolate framework-L decorated with multi-walled carbon nanotubes (MWCNTs/ZIF-L) was prepared by a facile solvent way and exploited as electrode material for sensitive electrochemical sensing of thiabendazole (TBZ). Two-dimensional ZIF-L presents high surface area, large pore volume, and abundant active sites, which exhibits high enrichment ability towards TBZ molecules, while the MWCNTs interspersed on ZIF-L can prominently enhance the electron transport capability and improve the electrocatalytic activity for TBZ oxidation.

Fast liquid chromatography method for separation of peptides using a sub-2 μm ground silica monolith packed column.

A stationary phase based on sub-2 μm ground silica monolith particles was fabricated by in situ polymerization and applied in micro-column for separation of peptides. The sub-2 μm silica particles were obtained from monolith using sol-gel process followed by grinding and sedimentation to remove the fines. Initially, the silica monolith particles were pretreated with 3-trimethoxysilyl propyl methacrylate to attach double-bonded ligands onto the surface, then a network structure was formed onto the surface of the particle using styrene, N-isopropylacrylamide, and ethylene glycoldimethacrylate.

Preparation of multicolor luminescence Schiff-base compound based on solvent control and its application in the detection of pentachloronitrobenzene.

Fluorescent materials with tunable optical properties are critical to their potential application. So far, the tuning of double-color luminescence has been easily achieved for many organic materials, but there are very few reports on multicolor luminescence materials. In this work, a multicolor emissions Schiff-base fluorescent compound 1,1'-{4,4'-Biphenyldiylbis[nitrilo(E)methylylidene]}di(2-naphthol) (BPDN) with an aggregation induced emission (AIE) characteristic was synthesized, and its luminescent characteristic was investigated.

Synthesis of Rottlerone Analogues and Evaluation of Their α-Glucosidase and DPP-4 Dual Inhibitory and Glucose Consumption-Promoting Activity.

Our previous study found that desmethylxanthohumol () inhibited α-glucosidase in vitro. Recently, further investigations revealed that dehydrocyclodesmethylxanthohumol () and its dimer analogue rottlerone () exhibited more potent α-glucosidase inhibitory activity than . The aim of this study was to synthesize a series of rottlerone analogues and evaluate their α-glucosidase and DPP-4 dual inhibitory activity.