Integrated genomic analysis of the stemness index signature of mRNA expression predicts lung adenocarcinoma prognosis and immune landscape.

mRNA expression-based stemness index (mRNAsi) has been used for prognostic assessment in various cancers, but its application in lung adenocarcinoma (LUAD) is limited, which is the focus of this study. Low mRNAsi in LUAD predicted a better prognosis. Eight genes () associated with mRNAsi were screened to establish a risk model.

Dynamic changes in serum albumin and ferritin indicate higher risk of early-onset peritonitis in peritoneal dialysis patients.

Introduction: The objective of this study is to investigate the dynamic changes in serum albumin and ferritin as potential predictors for early-onset peritoneal dialysis-related peritonitis (PDRP) in patients undergoing peritoneal dialysis (PD).

Methods: This retrospective study included 215 patients with end-stage renal disease who initiated PD at Huadong Hospital. Patients were followed up to 24 months, during which episodes of PDRP were recorded.

One-Year Risk Prediction of Elevated Serum Uric Acid Levels in Older Adults: A Longitudinal Cohort Study.

Objective: To develop and externally validate a nomogram to predict elevated serum uric acid (SUA) levels in older adults.

Study Design: This is a longitudinal Chinese cohort study.

Methods: A cohort of 2788 older adults was established at Huadong Hospital, followed-up for at least one year, and screened for risk factors for elevated SUA levels.

The role of moderate to vigorous physical activity level and number of treatments/medications in mediating the effect of body mass index on diabetic nephropathy: a Mendelian randomization study.

Background: Body mass index (BMI) is associated with diabetic nephropathy (DN). However, the mediator factors in the BMI-DN effects remain unclear.

Methods: Univariate and multivariate Mendelian randomization (MR) analysis were performed to estimate the association between six lifestyles (moderate to vigorous physical activity levels, years of schooling, BMI, nap during day, number of treatments/medications taken and coffee intake) and DN.

Multi-mode stable, high peak power Nd:YAG laser device for laser cleaning.

High average power and peak power solid-state lasers are of great interest in the field of laser cleaning. In this research, a high peak power laser with over 400 W average power using a multi-mode stable resonator in a diode-pumped Nd:YAG master oscillator power amplifier has been demonstrated. A maximum peak power over 1.

Synergistic Cathode Design for High-Performance Dual-Salt Magnesium/Lithium-Ion Batteries Using 2D/2D 1T/2H-MoS@TiCT MXene Nanocomposite.

Magnesium-ion batteries (MIBs) and dual-salt magnesium/lithium-ion batteries (MLIBs) have emerged as promising contenders for next-generation energy storage. In contrast to lithium metal anode in lithium metal batteries, magnesium metal anode in MIBs and MLIBs presents a safer alternative due to the limited dendrite growth and higher volumetric capacity, along with higher natural abundance. This study explores a MLIB configuration with a novel cathode design by employing a 2D/2D nanocomposite of 1T/2H mixed phase MoS and delaminated TiCT MXene (1T/2H-MoS@MXene) to address challenges associated with slow kinetics of magnesium ions during cathode interactions.

Pillar-Structured TiCT MXene with Engineered Interlayer Spacing for High-Performance Magnesium Batteries.

Two-dimentional (2D) TiCT MXene has attracted significant attention in non-lithium-ion batteries due to its excellent electrical conductivity, high volumetric capacity, and ability to accommodate intercalants. Rechargeable magnesium batteries with Mg metal anodes are noted for their high theoretical energy density, potential safety, earth abundance, dendrite-free Mg plating/stripping mechanism on the anode side, and low cost. Nevertheless, owing to the large polarity of divalent Mg ions, the insertion of Mg into the MXene layers suffers from sluggish kinetics, limiting the performance for storage of Mg ions.

Inflammatory cutaneous metastases originating from gastric cancer: A case report.

Background: Cutaneous metastasis with gastric cancer (GC) origin is extremely rare and associated with poor prognosis. Nodular type is the most common type, while other forms are extremely rare.

Case Summary: This study describes severe skin redness, swelling, pain, and fever in a 65-year-old man diagnosed with GC, whose left chest wall, left upper limb, and left back were mainly affected.

Phosphorus balance calculator: an individualized tool for treatment of hyperphosphatemia in hemodialysis patients.

Background: Lack of evaluations of the dietary phosphorus and dialysis phosphorus removal in daily clinical practice are common obstacles to assessing phosphorus balance and controlling phosphorus in hemodialysis patients. We aimed to investigate whether individualized therapy using a phosphorus balance calculator improves phosphorus control.

Methods: A randomized, open-label, multicenter, 4-week clinical trial was conducted.

The modified cross-suture technique for loop stoma reversal.

Technique: (1) A four-pointed star-shaped incision was made to separate the skin around the stoma intestine. (2) The stoma intestine was resected, and side-to-side or end-to-side anastomosis was performed to restore the continuity of the intestine. (3) The peritoneum and rectus sheath should be closed using continuous full-thickness sutures.

1T-2H Mixed-Phase MoS Stabilized with a Hyperbranched Polyethylene Ionomer for Mg /Li Co-Intercalation Toward High-Capacity Dual-Salt Batteries.

Dual-salt magnesium/lithium-ion batteries (MLIBs) benefit from fast lithium ion diffusion on the cathode side while providing safety due to the dendrite-free Mg stripping/plating mechanism on the anode side. Bulk MoS (B-MoS ), as a cathode for magnesium-ion batteries (MIBs), suffers from low conductivity and relatively van der Waals gaps and, consequently, resists against divalent Mg insertion due to the high Coulombic interactions. In MLIBs, it exhibits a Daniell-cell type mechanism with the sole accommodation of Li .

Generation of Photonic Nanojet Using Gold Film Dielectric Microdisk Structure.

Due to their narrow beam waist size, high intensity, and long propagation distance, photonic nanojets (PNJs) can be used in various fields such as nanoparticle sensing, optical subwavelength detection, and optical data storage. In this paper, we report a strategy to realize an SPP-PNJ by exciting a surface plasmon polariton (SPP) on a gold-film dielectric microdisk. In detail, an SPP is excited by the grating-coupling method, then it irradiates the dielectric microdisk to form an SPP-PNJ.

Sleep traits and risk of end-stage renal disease: a mendelian randomization study.

Background: Epidemiological evidence relating sleep disorders to end-stage renal disease (ESRD) has been obscure. The present study is sought to examine the association between sleep traits and ESRD.

Methods: For this analysis, we selected genetic instruments for sleep traits from published genome-wide association studies (GWAS).

cRGD-targeted heparin nanoparticles for effective dual drug treatment of cisplatin-resistant ovarian cancer.

Resistance to the chemotherapeutic agent cisplatin (DDP) is the primary reason for invalid chemotherapy of ovarian cancer. Given the complex mechanisms underlying chemo-resistance, the design of combination therapies based on blocking multiple mechanisms is a rationale to synergistically elevate therapeutic effect for effectively overcoming cancer chemo-resistance. Herein, we demonstrated a multifunctional nanoparticle (DDP-Ola@HR), which could simultaneously co-deliver DDP and Olaparib (Ola, DNA damage repair inhibitor) using targeted ligand cRGD peptide modified with heparin (HR) as nanocarrier, enabling the concurrent tackling of multiple resistance mechanisms to effectively inhibit the growth and metastasis of DDP-resistant ovarian cancer.

Exploring the use of sodium caseinate-assisted responsive separation for the treatment of washing effluents in shoreline oil spill response.

The produced effluents after shoreline washing contain a certain number of oil droplets and further treatment is necessary. In this study, the innocuous, widely available, and biodegradable sodium caseinate (NaCas) was deployed to capture oil pollutants from oily wastewater. Oil droplets can be effectively and rapidly captured by NaCas and subsequently removed after pH-triggered separation, producing a clean supernatant with low turbidity.

Characteristics and predictors of low-grade renal artery stenosis in female patients with CKD.

Aim: Renal artery stenosis (RAS) is an important cause of chronic kidney disease (CKD). The main purpose of this study was to explore the clinical characteristics and predictors of low-grade RAS in female patients with CKD.

Methods: One hundred and five female CKD patients from Huadong Hospital affiliated with Fudan University who underwent 3 T non-contrast renal artery magnetic resonance angiography (MRA) were analyzed.

Inhibition of MLL1-menin interaction attenuates renal fibrosis in obstructive nephropathy.

Mixed lineage leukemia 1 (MLL1), a histone H3 lysine 4 (H3K4) methyltransferase, exerts its enzymatic activity by interacting with menin and other proteins. It is unclear whether inhibition of the MLL1-menin interaction influences epithelial-mesenchymal transition (EMT), renal fibroblast activation, and renal fibrosis. In this study, we investigated the effect of disrupting MLL1-menin interaction on those events and mechanisms involved in a murine model of renal fibrosis induced by unilateral ureteral obstruction (UUO), in cultured mouse proximal tubular cells and renal interstitial fibroblasts.

A pH-responsive phosphoprotein washing fluid for the removal of phenanthrene from contaminated peat moss in the cold region.

Oil pollution is one of the major environmental concerns in the petroleum industry. In this study, a cheap food-grade sodium caseinate (NaCas) was used as a pH-responsive washing fluid in the remediation of phenanthrene (PHE) affected peat moss. The effects of environmental factors on the removal of PHE were systematically investigated.

Identification of core genes and pathways between geriatric multimorbidity and renal insufficiency: potential therapeutic agents discovered using bioinformatics analysis.

Background: Geriatric people are prone to suffer from multiple chronic diseases, which can directly or indirectly affect renal function. Through bioinformatics analysis, this study aimed to identify key genes and pathways associated with renal insufficiency in patients with geriatric multimorbidity and explore potential drugs against renal insufficiency.

Methods: The text mining tool Pubmed2Ensembl was used to detect genes associated with the keywords including "Geriatric", "Multimorbidity" and "Renal insufficiency".

Autophagy-dependent Na-K-ATPase signalling and abnormal urate reabsorption in hyperuricaemia-induced renal tubular injury.

Increasing evidence indicates that hyperuricaemia (HUA) is not only a result of decreased renal urate excretion but also a contributor to kidney disease. Na-K-ATPase (NKA), which establishes the sodium gradient for urate transport in proximal tubular epithelial cells (PTECs), its impairment leads to HUA-induced nephropathy. However, the specific mechanism underlying NKA impairment-mediated renal tubular injury and increased urate reabsorption in HUA is not well understood.

The association of urinary prostaglandins with uric acid in hyperuricemia patients.

Purpose: To explore the association between uric acid and urinary prostaglandins in male patients with hyperuricemia.

Methods: A total of 38 male patients with hyperuricemia in outpatients of Huadong Hospital from July 2018 to January 2020 were recruited. Serum uric acid (SUA), 24 h urinary uric acid excretion and other indicators were detected respectively.

Apatinib plus chemotherapy versus chemotherapy alone as neoadjuvant therapy in locally advanced gastric carcinoma patients: a prospective, cohort study.

Background: Apatinib, a small molecule targeting VEGFR2, is commonly used for advanced gastric cancer treatment. This prospective cohort study further investigated the efficacy and safety of neoadjuvant apatinib plus chemotherapy in locally advanced gastric carcinoma patients.

Methods: Ninety-six locally advanced gastric carcinoma patients were divided into the apatinib plus chemotherapy group (N = 45) and chemotherapy group (N = 51) according to their chosen treatment.

Exploring the characteristics, performance, and mechanisms of a magnetic-mediated washing fluid for the cleanup of oiled beach sand.

In the present study, an innovative, environmentally benign recyclable, and magnetically mediated surface washing fluid based on water-dispersible magnetite nanoparticles has been designed and investigated for the cleanup of oiled beach sand. The characterization results showed that the as-prepared magnetite nanoparticles had a spherical morphology with an average diameter of around 250 nm and the particle surface was successfully functionalized with carboxyl groups. The magnetite nanoparticles could be easily re-dispersed by lightly shaking the dispersion after withdrawing the magnet.

Dynamic and Reprocessable Fluorinated Poly(hindered urea) Network Materials Containing Ionic Liquids to Enhance Triboelectric Performance.

Triboelectric nanogenerators (TENGs), a newly developed energy harvesting device that converts surrounding environmental mechanical stimuli into electricity, have been significantly explored as an ideal long-term power source for electrical devices. Despite recent advances, the development of advanced TENG devices with sufficient outputs to sustainably power electronic devices and rapid self-healability under mild conditions to improve their lifetime and function is highly demanded. Here, we report a robust self-healable and reprocessable TENG fabricated with a covalent adaptive network based on mechanically strong fluorinated poly(hindered urea) (F-PHU) integrated with ionic liquid as an efficient dielectric material to improve its triboelectric efficiency and self-healing capability simultaneously.