Investigation of pathogenesis and therapeutic targets of acute myeloid leukemia based on untargeted plasma metabolomics and network pharmacology approach.

Acute myeloid leukemia (AML) is a malignant disease originating from bone marrow hematopoietic stem cells, characterized by anemia, hemorrhage, fever, and infection, with low survival rate. However, the pathogenesis of AML is not fully understood at present. In this work, an integrated approach based untargeted metabolomics and network pharmacology was adopted to elucidate the pathogenesis of AML.

Magnetic solid-phase extraction based on magnetic amino modified multiwalled carbon nanotubes for the fast determination of seven pesticide residues in water samples.

A rapid and simple analytical method based on magnetic solid-phase extraction with magnetic amino modified multiwalled carbon nanotubes with ultra-high performance liquid chromatography-tandem mass spectrometry is reported for the determination of seven pesticides (futriafol, metalaxyl, myclobutanil, napropamide, epoxiconazole, fipronil and diniconazole) in water samples. In this study, magnetic amino modified multi-walled carbon nanotubes were synthesized and selected as a new kind of material to adsorb pesticides in the water samples. Various magnetic solid-phase extraction parameters, such as the amount and type of adsorbent, extraction methods, extraction time, the type and volume of desorption solvent, desorption time and solution ionic strength, were systematically optimized.