HELQ deficiency impairs the induction of primordial germ cell-like cells.

Helicase POLQ-like (HELQ) is a DNA helicase essential for the maintenance of genome stability. A recent study identified two HELQ missense mutations in some cases of infertile men. However, the functions of HELQ in the process of germline specification are not well known and whether its function is conserved between mouse and human remains unclear.

Impact of 60 days of 6° head down bed rest on cardiopulmonary function, and the effects of Taikong Yangxin Prescription as a countermeasure.

Objective: To study the changes in cardiopulmonary function induced by mid/long-term simulated microgravity with 6° head down bed rest (HDBR), and the effects of Taikong Yangxin Prescription (, TYP) as a countermeasure.

Methods: Fourteen healthy male volunteers were randomly divided into a control group and a Chinese medicine (CM) group (7 in each group) by a random digital table based on their body weight. Both groups underwent 6° HDBR for 60 days.

Genetic influence on baroreflex sensitivity in normotensive young men.

Background: The dysfunction of baroreflex plays an important role in the pathogenesis of essential hypertension. Recent studies suggest that approximately 40% of the variation in baroreflex sensitivity (BRS) may be accounted for by genetic factors. However, only a few such genetic polymorphisms have been explicitly identified.

[Effects of 7 d head-down bed rest on human vectorcardiogram (VCG)].

Objective: To study the effects of short-term simulated weightlessness on human vectorcardiogram (VCG).

Method: Seven d -6 degrees head-down bed rest (HDBR) was used to simulate weightlessness. Eight healthy males, aged 19-21, served as the subjects.

[Effects of body position changes on frequency domain correlative cardiogram in pilots].

Objective: To study the effects of the body position changes on FCG in pilots so as to explore the possibility of using FCG as an indicator of medical monitoring and medical support.

Method: 65 pilots were examined in 4 different body positions, i.e.