Cinnamaldehyde prevents intergenerational effect of paternal depression in mice via regulating GR/miR-190b/BDNF pathway.

Paternal stress exposure-induced high corticosterone (CORT) levels may contribute to depression in offspring. Clinical studies disclose the association of depressive symptoms in fathers with their adolescent offspring. However, there is limited information regarding the intervention for intergenerational inheritance of depression.

miR-181a-5p suppresses invasion and migration of HTR-8/SVneo cells by directly targeting IGF2BP2.

Pre-eclampsia is a pregnancy-related disease that may cause maternal, neonatal and fetal morbidity and mortality and exists in 3-5% of pregnancies worldwide. The discovery of dysregulated microRNAs and their roles in placental development has provided a new avenue for elucidating the mechanism involved in this pregnancy-specific disorder. Here, the roles of human miR-181a-5p, a microRNA that is increased in both the plasma and placenta of severe pre-eclamptic patients, in invasion and migration of trophoblasts were investigated.

Clinical application of next-generation sequencing in preimplantation genetic diagnosis cycles for Robertsonian and reciprocal translocations.

Purpose: The purpose of this study was to apply next-generation sequencing (NGS) technology to identify chromosomally normal embryos for transfer in preimplantation genetic diagnosis (PGD) cycles for translocations.

Methods: A total of 21 translocation couples with a history of infertility and repeated miscarriage presented at our PGD clinic for 24-chromosome embryo testing using copy number variation sequencing (CNV-Seq).

Results: Testing of 98 embryo samples identified 68 aneuploid (69.

The Association of Maternal Body Composition and Dietary Intake with the Risk of Gestational Diabetes Mellitus during the Second Trimester in a Cohort of Chinese Pregnant Women.

Objective: To investigate the association of maternal body composition and dietary intake with the risk of gestational diabetes mellitus (GDM).

Methods: A total 154 GDM subjects and 981 controls were enrolled in a prospective cohort study in 11 hospitals from May 20, 2012 to December 31, 2013. Bioelectrical impedance analysis and dietary surveys were used to determine body composition and to evaluate the intake of nutrients in subjects at 21-24 weeks' gestation (WG).

[Influence of acupuncture and moxibustion pretreatment at "Neiguan" (PC 6) on Connexin 43 in myocardial cell in rabbits of myocardial ischemia reperfusion].

Objective: To observe change of expression level of Connexin 43 (Cx 43) in myocardial mitochondria of ischemia reperfusion injury after pretreatment of acupuncture and moxibustion at "Neiguan" (PC 6) in rabbits, Thirty-two New Zealand and compare the different effect between electroacupuncture and moxibustion.

Methods: big-eared white rabbits were randomly divided into a model group, an electroacupuncture group, a moxibustion group and a sham-operation group, 8 cases in each one. The model of myocardial ischemia reperfusion injury was established in the first three groups.

The human leukocyte antigen G promotes trophoblast fusion and β-hCG production through the Erk1/2 pathway in human choriocarcinoma cell lines.

The human leukocyte antigen G (HLA-G) is expressed on the fetal-maternal interface and plays a role in protecting fetal-derived trophoblasts from the maternal immune response, allowing trophoblasts to invade the uterus. However, HLA-G also possesses immune suppressing-independent functions. We found that HLA-G expressing BeWo choriocarcinoma cells increased cell-cell fusion compared to control BeWo cells under forskolin treatment.

[Value of detection of cell-free fetal DNA in maternal plasma in the prenatal diagnosis of chromosomal abnormalities].

Objective: To investigate the value of detection of fetal cell-free fetal DNA (cff-DNA) in maternal plasma in the prenatal diagnosis of chromosomal abnormalities.

Methods: The plasma from 3200 gravidas (singleton with 20.3 ± 3.

[Development of multiple quantitative fluorescent PCR for rapid diagnosis of common aneuploidy and it's clinical application].

In this study we have established a technique of multiple quantitative fluorescent polymerase chain reaction (QF-PCR) for prenatal diagnosis of common chromosomal abnormality using multiple short tandem repeat markers (STR-marker) on chromosomes 21 and 18 with the DNA samples from 20 cases of Down's syndrome, 3 cases of trisomy 18 and 40 cases normal controls. The technique established was applied in prenatal diagnosis in 165 clinical cases and 4 cases of newborn infants with digestive tract obstruction. The result this technique was compared with the results of karyotyping.