Publications by authors named "Zhi-xing Jiao"
Objective: To investigate the molecular mechanisms underlying the effects of arsenic trioxide (AsO) in combination with leflunomide on the hamster-to-rat heart xenotransplant.
Methods: Transplantation of LVG hamster hearts to Lewis rats was performed by anastomosis of vessels in the neck using end-to-end anastomosis with a non-suture cuff technique. Four groups of recipient rats (n=6 in each) were treated with normal saline (control), AsO [5 mg/(kg·day) intraperitoneally], leflunomide [5 mg/(kg·d) orally], or leflunomide [5 mg/(kg·d)+AsO [5 mg/(kg·d)] in combination.
Article Synopsis
- Xenotransplantation aims to address the critical shortage of human organs for transplantation, but challenges like immune rejection limit its effectiveness.
- Researchers explored the immunosuppressive effects of As2 O3 and leflunomide in a hamster-to-rat heart xenotransplantation model.
- The combination of As2 O3 and leflunomide significantly improved heart graft survival while showing low toxicity to the recipient's organs, suggesting a potential new approach for xenotransplantation.
Background: Endostatin is a potent inhibitor of tumor angiogenesis. In the preliminary studies, we developed a mutant endostatin containing Arg-Gly-Asp-Arg-Gly-Asp (RGDRGD) sequences. In this study, we compared the antitumor effects of mutant endostatin and Bcl-2 antisense oligonucleotides both in combination and individually.
View Article and Find Full Text PDFObjectives: To evaluate the safety and efficacy of performing ultrasound-guided minimally invasive percutaneous nephrolithotomy (MPCNL) in the flank position for the management of complex renal calculi. Percutaneous nephrolithotomy is usually performed with the patient in the prone position under fluoroscopic guidance; however, this position, and guidance method have some limitations.
Methods: From January 2007 to December 2009, 93 patients (101 kidneys) with complex renal calculi underwent ultrasound-guided MPCNL in the flank position.
[Effects of irrigating fluid absorption in percutaneous nephrolithotripsy].
Zhonghua Yi Xue Za Zhi
January 2010
Objective: To determine the hemodynamic status, fluid-electrolyte changes and complications associated with irrigation time in percutaneous nephrolithotripsy.
Methods: A total of 68 renal calculi patients (31 males and 37 females) were recruited. The lateral recumbent percutaneous nephrolithotripsy was operated with Ho laser under ultrasonic guidance.
Objective: To explore the optimal method for protein expression in rhES (recombinant human endostatin) and study the anti-tumor activities of rhES in solid tumor and established cell line.
Methods: Different IPTG concentrations, the timing of adding IPTG into the culture medium and the different time of expression were employed to explore the optimized conditions of protein expression. Activity examination: (1) animal experiment: nude mice bearing subcutaneous cancer in treated group and controlled group were observed.
[Treatment of ureteral obstruction by holmium: YAG laser endoureterotomy: a report of 18 cases].
Zhonghua Yi Xue Za Zhi
February 2009
Objective: To investigate the clinical value and safety of holmium: YAG laser endoureterotomy in the treatment of ureteral obstruction.
Methods: Holmium: YAG laser endoureterotomy, with the laser optic fiber 550 microm in diameter and the output power of 3.5 Watt, via ureteroscopy, was performed on 18 patients ureteral obstruction, 8 males and 10 females, aged 52.