Adverse events of guselkumab in the real world: emerging signals to target preventive strategies from the FDA adverse event reporting system.

Background: Guselkumab is an IL-23 inhibitor widely used for the treatment of moderate-to-severe plaque psoriasis. Our study aimed to characterize the profile of adverse events (AEs) associated with guselkumab from the FDA adverse event reporting system (FAERS).

Methods: Disproportionality analysis including the proportional reporting ratio (PRR), the reporting odds ratio (ROR), the Bayesian confidence propagation neural network (BCPNN), and the multiitem gamma Poisson shrinker (MGPS) algorithms were used to assess the signals of guselkumab related AE.

Timosaponin derivative YY-23 acts as a non-competitive NMDA receptor antagonist and exerts a rapid antidepressant-like effect in mice.

Aim: N-methyl-D-aspartic acid (NMDA) receptor modulators have shown promising results as potential antidepressant agents, whereas timosaponins extracted from the Chinese herb Rhizoma Anemarrhenae exhibit antidepressant activities. In the present study we examined whether YY-23, a modified metabolite of timosaponin B-III, could affect NMDA receptors in rat hippocampal neurons in vitro, and evaluated its antidepressant-like effects in stressed mice.

Methods: NMDA-induced currents were recorded in acutely dissociated rat hippocampal CA1 neurons using a whole-cell recording technique.

[Relationship between photosynthetic characteristics and environmental factors in leaves of Pueraria lobata].

Objective: To study the relationship between photosynthetic characteristics and environmental factors in leaves of P. lobata.

Method: Photosynthetic characteristics and environmental factors were measured by using CIRAS-2 portable photosynthesis system.

[Study on seed quality test and quality standard of Platycodon grandiflorum].

Objective: To study quality test, and establish quality classification standard of Platycodon grandiflorum.

Method: The seed quality and planting quality of P. grandiflorum from different producing areas and in different growing years were measured.