Publications by authors named "Zhi-wei Lin"

Cutaneous photoaging, induced by chronic exposure to ultraviolet (UV) radiation, typically manifests as alterations in both the physical appearance and functional properties of the skin and may predispose individuals to cancer development. Recent studies have demonstrated the reparative potential of exosomes derived from mesenchymal stem cells in addressing skin damage, while specific reports highlight their efficacy in ameliorating skin photoaging. However, the precise role of exosomes derived from human hair follicle mesenchymal stem cells (HFMSC-Exos) in the context of cutaneous photoaging remains largely unexplored.

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Evidence on the link of long-term exposure to ozone (O) with childhood asthma, rhinitis, conjunctivitis and eczema is inconclusive. We did a population-based cross-sectional survey, including 177,888 children from 173 primary and middle schools in 14 Chinese cities. A satellite-based spatiotemporal model was employed to assess four-year average O exposure at both residential and school locations.

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Background: Monocyte-derived alveolar macrophages (Mo_AMs) are increasingly recognised as potential pathogenic factors for idiopathic pulmonary fibrosis (IPF). While scRNAseq analysis has proven valuable in the transcriptome profiling of Mo_AMs, the integration analysis of multi-omics may provide additional dimensions of understanding of these cellular populations.

Methods: We performed multi-omics analysis on 116 scRNAseq, 119 bulkseq and five scATACseq lung tissue samples from IPF.

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Perfluoroalkyl acids (PFAAs) are ubiquitous environmental contaminants of global concern, and adsorption processes are the most widely used technologies to remove PFAAs from water. However, there remains little data on the ways that specific water matrix constituents inhibit the adsorption of PFAAs on different adsorbents. In this study, we evaluated the adsorption of 13 PFAAs on two styrene-functionalized β-cyclodextrin (StyDex) polymers, an activated carbon (AC), and an anion-exchange resin (AER) in the absence and presence of specific water matrix constituents (16 unique water matrices) in batch experiments.

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Article Synopsis
  • - Cross-linked β-cyclodextrin (β-CD) polymers serve as effective adsorbents for removing harmful per- and polyfluoroalkyl substances (PFAS) from water sources, showcasing their potential in treating contaminated environments.
  • - The study evaluates 20 different StyDex polymer variations with different comonomer structures and configurations, identifying one with dimethylbutyl ammonium ions as the best performer for PFAS adsorption in batch tests.
  • - The research highlights that the arrangement of styrene groups on β-CD monomers did not significantly affect performance, suggesting a simpler preparation method that maintains effectiveness, paving the way for cost-efficient adsorbent development.
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  • Carbapenem-resistant Acinetobacter baumannii (CRAB) poses a challenge to antibiotic treatment, but eravacycline shows promise as a potential treatment option; however, its resistance mechanisms remain unclear.
  • A study of 287 CRAB isolates from China identified that approximately 17% exhibited heteroresistance to eravacycline, mainly among strains that also produced the OXA-23 carbapenemase, with a significant correlation to higher expression levels of certain resistance genes.
  • The study found that the presence of efflux pump inhibitors could reduce eravacycline resistance, indicating potential avenues for improving treatment strategies against CRAB infections. *
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In recent years, stem cells and their secretomes, notably exosomes, have received considerable attention in biomedical applications. Exosomes are cellular secretomes used for intercellular communication. They perform the function of intercellular messengers by facilitating the transport of proteins, lipids, nucleic acids, and therapeutic substances.

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Purpose: The need for adjuvant therapy (AT) following neoadjuvant chemoimmunotherapy (nICT) and surgery in esophageal squamous cell cancer (ESCC) remains uncertain. This study aims to investigate whether AT offers additional benefits in terms of recurrence-free survival (RFS) for ESCC patients after nICT and surgery.

Methods: Retrospective analysis was conducted between January 2019 and December 2022 from three centers.

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Surgical adhesives play a crucial role in tissue integration and repair, yet their application in wet conditions has been severely limited by inadequate adhesive strength and subpar biocompatibility. Furthermore, tissue adhesives have rarely been reported in cartilage tissue repair. In this study, a three-armed dopamine-modified hyaluronic acid derivative adhesive was prepared to function as a bio-inspired adhesive in moist environments.

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Cell-based assays enable molecular-level studies of cellular responses to drug candidates or potential toxins. Transactivation assays quantify the activation or inhibition of nuclear receptors, key transcriptional regulators of gene targets in mamalian cells. One such assay couples the expression of luciferase to the transcriptional activity of estrogen receptor-alpha (ERα).

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Trace organic contaminants (TrOCs) present major removal challenges for wastewater treatment. TrOCs, such as perfluoroalkyl and polyfluoroalkyl substances (PFAS), are associated with chronic toxicity at ng L exposure levels and should be removed from wastewater to enable safe reuse and release of treated effluents. Established adsorbents, such as granular activated carbon (GAC), exhibit variable TrOC removal and fouling by wastewater constituents.

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Stable isotope chemical labeling methods have been widely used for high-throughput mass spectrometry (MS)-based quantitative proteomics in biological and clinical applications. However, the existing methods are far from meeting the requirements for high sensitivity detection. In the present study, a novel isobaric stable isotope N-phosphorylation labeling (iSIPL) strategy was developed for quantitative proteome analysis.

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This study involves isothermal kinetic simulation to evaluate the parameters of inhibition conditions for () and () of high-risk pathogens. This is because the new type of the 2019 novel coronavirus (2019-nCoV) is continuously spreading and the importance of public health issues. Environmental disinfection and personal wearing of masks have become important epidemic prevention measures.

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Postoperative cognitive dysfunction (POCD) is consequence of anesthesia and surgery that primarily affects older people. The prevention and treatment of POCD has drawn an increasing attention in recent decades. Here, we established the animal model mimicked POCD after femoral fracture surgery, and analyze the effect of acupuncture stimulation on postoperative cognitive function after femoral fracture surgery.

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Article Synopsis
  • - The study investigates the risk factors for the recurrence of colorectal polyps after endoscopic removal, focusing on the potential relationship between blood lipid levels and polyp recurrence.
  • - Data from 357 patients who had been treated for polyps revealed that higher triglyceride and apolipoprotein B levels, along with the number of polyps, were significant indicators of recurrence risk.
  • - The research suggests that managing high triglyceride and apolipoprotein B levels may help reduce the likelihood of polyp recurrence in at-risk patients.
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The di-2-ethylhexyl phthalate (DEHP) degrading strain LMB-7 was isolated from electronic waste soil. According to its biophysical/biochemical characteristics and 16S rRNA gene analysis, the strain was identified as Nocardia asteroides. Optimal pH and temperature for DEHP degradation were 8.

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Cross-linked polymers containing β-cyclodextrin (β-CD) are promising adsorbents with demonstrated removal performances for per- and polyfluoroalkyl substances (PFASs) from contaminated water sources. Despite the promising performance of some β-CD-based adsorbents for PFAS removal, many of these materials are not amenable for rational performance improvement or addressing fundamental questions about the PFAS adsorption mechanisms. These ambiguities arise from the poorly defined structure of the cross-linked polymers, especially with respect to the random substitution patterns of the cyclodextrins as well as side reactions that modify the structures of some cross-linkers.

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The unsatisfactory performance of current gadolinium chelate based contrast agents (CAs) for magnetic resonance imaging (MRI) stimulates the search for better alternatives. Herein, we report a new strategy to substantially improve the capacity of nanoparticle-based CAs by exploiting the photoinduced superhydrophilic assistance (PISA) effect. As a proof of concept, we synthesized citrate-coated Gd-doped TiO ellipsoidal nanoparticles (GdTi-SC NPs), whose increases significantly upon UV irradiation.

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Introducing a weak covalent bond into an originally highly fluorescent molecule to create a non-fluorescent probe is able to provide a new way to detect some nucleophilic targets with enhanced sensitivity. Herein, this is the first time that a tetraphenylethene (TPE)-based probe (TPEONO) bearing a -nitrobenzenesulfonyl moiety for the sensing of F ions in aqueous solution a cleavage reaction of the sulfonyl ester bond to induce aggregation-induced emission (AIE) has been reported.

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To evaluate the effect of thrombus aspiration (TA) strategy on the outcomes and its interaction with D-dimer levels in patients with ST-segment elevation myocardial infarction (STEMI) during primary percutaneous coronary intervention (PCI) in "real-world" settings. This study included 1,295 patients with STEMI who had undergone primary PCI with or without TA between January 2013 and June 2017. Patients were first divided into a TA+PCI group and a PCI-only group, and the baseline characteristics and long-term mortality between the two groups were analyzed.

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Exopolysaccharides (EPSs) such as capsular polysaccharide (CPS) are important bioactive carbohydrate compounds and are often used as bioenrichment agents and bioabsorbers to remove environmental pollutants like di-n-butyl phthalate (DBP). Among the EPS-producing bacteria, lactic acid bacteria (LAB) have gained the most attention. As generally recognized as safe (GRAS) microorganisms, LAB can produce EPSs having many different structures and no health risks.

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Plasticizers belong to hormone-like substances existing widely in the environment. According to the Environmental Protection Agency of China, they are considered to be the fourth class of toxic chemicals due to their harmful effects on normal endocrine system in human bodies. In the recent published work of our lab, Lactobacillus plantarum CGMCC18980 (strain P1) could reduce the toxicity of di-butyl phthalate (DBP) in rats effectively.

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Breast cancer metastasis is a leading cause of cancer-related death of women in the United States. A hurdle in advancing metastasis-targeted intervention is the phenotypic heterogeneity between primary and secondary lesions. To identify metastasis-specific gene expression profiles we performed RNA-sequencing of breast cancer mouse models; analyzing metastases from models of various drivers and routes.

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Article Synopsis
  • A study identified 124 cases of multidrug-resistant hypervirulent Klebsiella pneumoniae (MDR-hvKP) from clinical isolates, revealing that this strain poses a significant public health threat due to its high virulence and varying levels of antibiotic resistance.* -
  • The hypervirulent strains exhibited distinct characteristics, such as higher frequencies of specific virulence genes and capsular serotype K1 compared to classic Klebsiella, especially in non-MDR and extended-spectrum beta-lactamase producing groups.* -
  • The research demonstrated that lower expression of certain virulence factors in classic Klebsiella linked to decreased hypervirulence, while some hypervirulent strains showed resistance to certain antibiotics like tig
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