Publications by authors named "Zhi-shan Zhang"

Article Synopsis
  • Nanozymes, specifically a novel CuO nanoparticle system, utilize reactive oxygen species (ROS) produced in response to high alkaline phosphatase (ALP) levels in bacteria for targeted antibacterial action.
  • The prodrug approach employs 2-phospho-L-ascorbic acid trisodium salt (AAP), which is activated by ALP in pathogenic bacteria like E. coli to generate ascorbic acid, ultimately leading to ROS production and selective bacterial killing.
  • Testing in a rat model shows that the CuO NPs/AAP system effectively disinfects wounds with minimal side effects, indicating a promising method for precise antimicrobial treatment.
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  • * A total of 271,981 vertebral fractures were recorded, with the incidence increasing from approximately 85 per 100,000 person-years in 2013 to 152 per 100,000 in 2017, showing a significant upward trend.
  • * Medical costs associated with these fractures skyrocketed from about $92.74 million in 2013 to $505.3 million in 2017, highlighting the urgent need for improved osteoporosis management strategies.
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We investigated the decomposition characteristics of , mosses, and leaves of with litterbag method in the sand-binding revegetation area, southeastern edge of the Tengger Desert, and further examined their effects on soil microbial communities using the Illumina MiSeq sequencing method. The results showed that the decomposition duration and litter types significantly affected litter decomposition rate. Mosses had the lowest decomposition rate, with a mass loss ratio of only 15.

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Objective: To assess the therapeutic effect of a novel tension band using 3.0 mm cannulated screw combined with a titanium cable and specific shims comparatively with patellotibial tubercle cerclage in comminuted fractures of the inferior pole of the patella.

Methods: The retrospective study from March 2012 to July 2017 was conducted in Peking University Third Hospital and comprised 63 patients with comminuted fractures of the inferior pole of the patella: 41 treated with new tension band using 3.

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Background: The purpose of this study was to analyze cases of AO31-A2 intertrochanteric fractures (ITFs) and to identify the relationship between the loss of the posteromedial support and implant failure.

Methods: Three hundred ninety-four patients who underwent operative treatment for ITF from January 2003 to December 2017 were enrolled. Focusing on posteromedial support, the A2 ITFs were divided into two groups, namely, those with (Group A, n = 153) or without (Group B, n = 241) posteromedial support post-operatively, and the failure rates were compared.

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Objective: To investigate the gene mutation types and gene carrying rate of common thalassemia in patients with thalassemia in Quanzhou, and to analyze its molecular epidemiological characteristics in Quanzhou.

Methods: 546 patients with thalassemia diagnosed at the first hospital of Quanzhou from January 2017 to October 2018 were collected and retrospectively analyzed for their types of mutations and carrier rates.

Results: Among the 4226 samples submitted, 546 positive samples were detected, the total carrying rate of the thalassaemia genes was 12.

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Background: Reverse intertrochanteric fractures are usually initially treated with closed reduction. However, sometimes these fractures are not amenable to closed reduction and require open reduction. To date, few studies have been conducted on predictors of and reduction techniques for irreducible reverse intertrochanteric fractures.

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Clear cell renal cell carcinoma (ccRCC) is one of the most common types of kidney cancer and is accompanied by a poor prognosis due to a high potential for metastasis and recurrence. The mechanism of ccRCC metastasis is not well known. N-lysine methyltransferase KMT5A serves a crucial role in the progression of human cancer; however, the function of KMT5A in the development of ccRCCs has not yet been investigated, which has triggered an interest in investigating the potential association between KMT5A and ccRCC.

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Article Synopsis
  • The study aimed to explore the prevalence and types of thalassemia genes among women of childbearing age in the Quanzhou region, using venous blood samples for analysis.
  • Out of 7,082 samples, 384 were found to carry thalassemia genes, with a carrier rate of 5.42%, including 3.21% for alpha and 2.15% for beta thalassemia.
  • The most common genotypes identified were --/αα for alpha thalassemia and IVS-Ⅱ-654/N for beta thalassemia, highlighting the need for improved screening and genetic counseling in the area.
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We sequenced and characterized the complete mitochondrial genome of golden yellow snakehead fish, The mitogenomes contained the typical complement of 13 protein-coding genes, 22 transfer RNAs (tRNAs), 2 ribosomal RNAs (rRNAs), and a non-coding control region. They share the same gene arrangement pattern that was identical with most vertebrates. The entire mitochondrial DNA molecule of golden yellow snakehead fish was 16,558 bp long.

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Biological soil crusts across the desert regions play a key role in regional ecological security and ecological health. They are vital biotic components of desert ecosystems that maintain soil stability, fix carbon and nitrogen, influence the establishment of vascular plants, and serve as habitats for a large number of arthropods and microorganisms, as well as influencing soil hydrological processes. Changes in temperature and precipitation are expected to influence the functioning of desert ecosystems by altering biotic components such as the species composition of biological soil crusts.

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Background: Rabies is a global fatal infectious viral disease that is characterized by a high mortality after onset of clinical symptoms. Recently, there has been an increase in the incidence of rabies in China. The aim of this study was to investigate the incidence of human rabies and characterize the rabies virus nucleoprotein gene in dogs sampled from Fujian Province, Southeast China from 2002 to 2012.

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In water-limited regions, rainfall interception is influenced by rainfall properties and crown characteristics. Rainfall properties, aside from gross rainfall amount and duration (GR and RD), maximum rainfall intensity and rainless gap (RG), within rain events may heavily affect throughfall and interception by plants. From 2004 to 2014 (except for 2007), individual shrubs of Caragana korshinskii and Artemisia ordosica were selected to measure throughfall during 210 rain events.

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The objective of this study was to investigate species composition, and predict future development of dominant species on semi-fixed sand dunes in the Gurbantongut Desert. Using the plant height, crown area and volume instead of age structure, the growth and development condition of dominant shrub populations were analyzed. The results showed that totally 23 species were observed, of which Chenopodiaceae occurred the most with 6 genera 8 species, followed by Asteraceae with 5 genera 6 species.

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Two types of soil covered by biological soil crusts (BSCs) , i.e. moss and algae, and moving sand in the natural vegetation area at the southeast fringe of the Tengger Desert were collected intactly.

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Introduction: Difficult removal of locking plates including less invasive stabilisation systems (LISSs) and locking compression plates (LCPs) sometimes occur. However, investigations of the mechanisms and correlated factors of complicated removal remain scant. This study aims to identify correlated factors for the difficult removal of locking plates and to propose suggestions for decision making regarding implant removal and the prevention of complicated removal.

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Purpose: Tracheostomy may become indispensable for patients with acute traumatic cervical spinal cord injuries. However, the early prediction of a tracheostomy is often difficult. Previous prediction models using the pulmonary function test (PFT) have limitations because some severely injured patients could not provide acceptable PFT results.

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There is currently no effective vaccine to prevent dengue infection, despite the existence of multiple studies on potential methods of immunization. The aim of the present study was to explore the effect of DNA and/or recombinant protein on levels of neutralizing antibodies. For this purpose, envelope domain IIIs of dengue serotypes 1 and 2 (DEN-1/2)were spliced by a linker (Gly‑Gly‑Ser‑Gly‑Ser)3 and cloned into the prokaryotic expression plasmid pET30a (+) and eukaryotic vector pcDNA3.

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Esophageal carcinoma is one of the world's deadliest cancers. Esophageal squamous cell carcinoma (ESCC) is more frequent than adenocarcenoma (AC) in China. Platinum-based chemotherapy with surgical resection is a common treatment approach for ESCC; however, the treatment response is uncertain.

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Uncertainties still existed for evaluating greenhouse gases fluxes (GHGs), including carbon dioxide (CO2), methane (CH4) and nitrous oxide (N2O) at the regional scale for desert ecosystem because available GHGs data about biological soil crusts (BSCs) was very scarce. In 2011 and 2012, soil ecosystem covered by various types of BSCs and BSCs at different succession stages in an artificial sand-fixing vegetation region established in various periods at southeast of the Shapotou area in Tengger Desert was selected to measure fluxes of CO2, CH4 and N2O using static chamber and gas chromatography. The results showed that curst type, recovery time and their interactions with sampling date significantly affected CO2 flux.

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The main prevention and control area for wind-blown sand hazards in northern China is about 320000 km(2) in size and includes sandlands to the east of the Helan Mountain and sandy deserts and desert-steppe transitional regions to the west of the Helan Mountain. Vegetation recovery and restoration is an important and effective approach for constraining wind-blown sand hazards in these areas. After more than 50 years of long-term ecological studies in the Shapotou region of the Tengger Desert, we found that revegetation changed the hydrological processes of the original sand dune system through the utilization and space-time redistribution of soil water.

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Objective: To analyze blood loss in perioperative period of femoral intertrochanteric fractures in old patients treated with Gamma interlocking intramedullary nail (Gamma3), proximal femoral nail antirotation (PFNA) and dynamic hip screw (DHS), and to comprehend the character of blood loss in perioperative period of femoral intertrochanteric fractures.

Methods: A retrospective analysis was made of the medical records of 408 old patients with femoral intertrochanteric fractures admitted to our hospital between January 1, 2007 and to December 31, 2012. The estimated blood loss was calculated by Gross equation, according to the height, weight and changes of blood test pre- and post-operation and the differences of blood loss among Gamma3 group, PFNA group and DHS group were compared.

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Objective: To investigate the comparison of curative effects in treating proximal humerus fractures' patients between minimally invasive locking plate internal fixation and open reduction with internal fixation, and to provide guidance for the operation method of the proximal humerus fracture patients.

Methods: In the study, 157 patients of proximal humerus fractures from May 2006 to December 2012 in Peking University Third Hospital were analyzed retrospectively, of whom 78 were followed up, including 19 males and 59 females. They were from 15 to 90 years old, with the mean age of 60.

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Taking three typical types of biological soil crusts (BSCs), i.e., cyanobacterial-algal crust, lichen crust, and moss crust, in the southeast fringe of Tengger Desert as test objects, this paper studied their nitrogen fixation potential, seasonal fluctuation, and responses to the environmental factors from June 2010 to May 2011.

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Genotyping of hepatitis C virus (HCV) can provide valuable information for prognosis and treatment duration prediction. To explore the genetic diversity of HCV in Fujian Province, China, 112, 104 and 48 anti-HCV-positive serum samples were collected from volunteer blood donors, IDUs and patients, respectively, from Jan 2008 to Dec 2008 and were genotyped through sequence analysis, followed by phylogenetic analysis in the C/E1 and NS5B regions. Genotypes could be determined for 85.

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