Publications by authors named "Zhi-peng Liang"
Prognostic impact of primary versus secondary resistance to sorafenib in patients with HCC.
Ther Adv Med Oncol
January 2025
Background: Sorafenib is a first-line treatment option for patients with hepatocellular carcinoma (HCC). However, the impact of sorafenib resistance type on patient survival prediction and choice of second-line treatment regimen is unknown.
Objectives: This study aims to explore the factors predicting resistance in patients with HCC receiving sorafenib, the impact of resistance on survival, and the optimal second-line treatment regimen.
[Cloning and functional characterization of oxidosqualene cyclase gene for α-amyrin synthesis].
Zhongguo Zhong Yao Za Zhi
June 2024
Article Synopsis
- Ursolic acid is gaining attention for its pharmacological properties and market potential, but current extraction methods from loquat leaves are inefficient and costly.
- A biosynthesis approach using α-amyrin as a precursor offers a promising alternative, as its yield is linked to ursolic acid production.
- Researchers identified and cloned four enzymes from different plants capable of producing α-amyrin, with AaOSC2 showing the highest efficiency, which can help in developing engineered yeast strains for enhanced ursolic acid production.
Leonurine, an active natural alkaloid compound isolated from Herba leonuri, has been reported to exhibit promising anticancer activity in solid tumors. The aim of this study was to explore whether leonurine is able to inhibit chronic myeloid leukemia (CML) malignancy. Here, we found that leonurine dose dependently inhibited the proliferation, migration, colony formation and promoted apoptosis of CML cells.
View Article and Find Full Text PDFA three-component reaction of olefin, diselenide and water, alcohols, phenol, carboxylic acid, or amine by a commercially available hypervalent iodine(III) reagent, PhIO, was developed. This method provides access to a wide range of vicinally functionalized selenoderivatives under ambient conditions with mostly excellent yields and high diastereoselectivity. The developed reaction displays high levels of functional group compatibility and is suitable for the late-stage functionalization of styrene-functionalized biomolecules.
View Article and Find Full Text PDF[Clinical study of iron metabolism indicators in ineffective hematopoiesis of myelodysplastic syndrome].
Zhongguo Shi Yan Xue Ye Xue Za Zhi
August 2013
This study was purposed to investigate the iron metabolism changes and their clinical significance in myelodysplastic syndrome (MDS). Thirty eight transfusion independent MDS patients and 49 controls (21 AA patients, 28 normal volunteers) were enrolled in this study. The iron metabolism indicators including serum iron protein (SF), serum iron (SI), transferrin protein (Tf), total iron binding capacity (TIBC), transferrin saturation (TS), soluble transferrin receptor (sTfR) were detected, the intracellular and extracellular iron distribution were observed under microscope, the chromosome karyotype was analysis by FISH.
View Article and Find Full Text PDFInhibitory effects of prostaglandin E1 on activation of hepatic stellate cells in rabbits with schistosomiasis.
Hepatobiliary Pancreat Dis Int
April 2007
Article Synopsis
- Liver fibrosis is caused by an imbalance in the liver's extracellular matrix, primarily due to the activation of hepatic stellate cells (HSCs), and schistosomiasis is a common trigger in China.
- The study investigated how prostaglandin E1 (PGE1) affects HSC activation and collagen type alterations in rabbits infected with Schistosoma japonicum.
- Results showed that PGE1 significantly inhibited HSC activation and reduced the levels of collagen associated with liver fibrosis, suggesting its potential as a therapy alongside praziquantel.
Article Synopsis
- The study aimed to examine the structure of lymph vessels in gastric cancer tissues and how it relates to cancer spread (metastasis).
- Researchers analyzed tissues from 32 gastric cancer cases, noting morphological changes in lymph vessels and capillaries.
- Findings indicated that lymph vessels in cancerous areas showed larger sizes and that swollen lymph vessels help cancer cells spread, particularly through well-formed lymph capillaries in nearby tissues.