Depression and risk of arthritis: A Mendelian randomization study.

Introduction: Observational studies have found that most patients with arthritis have depression. We aimed to determine the causal relationship between various types of arthritis and depression.

Methods: We conducted a two-sample bidirectional Mendelian randomized (MR) analysis to determine whether there was a significant causal relationship between depression and multiple types of arthritis.

Assessment of chemotherapy resistance changes in human colorectal cancer xenografts in rats based on MRI histogram features.

Purpose: We investigated the value of magnetic resonance imaging (MRI) histogram features, a non-invasive method, in assessing the changes in chemoresistance of colorectal cancer xenografts in rats.

Methods: A total of 50 tumor-bearing mice with colorectal cancer were randomly divided into two groups: control group and 5-fluorouracil (5-FU) group. The MRI histogram characteristics and the expression levels of p53 protein and MRP1 were obtained at 24 h, 48 h, 72 h, 120 h, and 168 h after treatment.

Molecular cloning of IKKβ from the mandarin fish Siniperca chuatsi and its up-regulation in cells by ISKNV infection.

The IκB kinase β (IKKβ) plays crucial roles in regulating activation of nuclear factor-kappa B (NF-κB) in response to proinflammatory factors and microbial and viral infections. Here, we report the cloning of an IKKβ cDNA (named SicIKKβ) from the mandarin fish Siniperca chuatsi. The full-length cDNA is 4052bp and contains an ORF that encodes a predicted protein of 743-amino acid residues.

[CT manifestations of the thymic carcinoid and literature review].

Objective: To investigate the CT manifestations of thymic carcinoid and assess the diagnostic value of CT for this disease.

Methods: CT and clinical findings of 5 patients (4 males and 1 female, average age 41 years) with histologically confirmed thymic carcinoid were retrospectively analyzed.

Results: The clinical findings of the 5 patients showed no specificity, and none of the patients presented with carcinoid syndrome.

[Correlation between magnetic resonance imaging findings and proliferating cell nuclear antigen expression in peripheral lung cancer].

Objective: To study the correlation between magnetic resonance imaging (MRI) findings and proliferating cell nuclear antigen (PCNA) expression in peripheral lung cancer.

Methods: The expression of PCNA was detected by means of SABC immunohistochemistry in 45 cases of surgically and pathologically confirmed peripheral lung cancer. The correlation between PCNA expression in the tumors and the MRI findings was analyzed.

Functional characterisation of altered outer membrane proteins for tetracycline resistance in Escherichia coli.

Alterations in the outer membrane (OM) proteome in response to tetracycline have been reported in Escherichia coli K-12, but information regarding their functional profile is not available. In this study, upregulation of FimD, Tsx, OmpW, OmpC and TolC and downregulation of LamB in response to tetracycline were detected and confirmed by two-dimensional gel electrophoresis subproteomics and Western blotting, respectively. The ability of the six altered OM proteins was investigated using genetically modified strains with gene deletion or complementation.