Publications by authors named "Zhi-mi Huang"
[Emergence of novel variants of gyrA, parC, qnrS genes in multi-drug resistant Klebsiella caused pneumonia].
Zhonghua Liu Xing Bing Xue Za Zhi
January 2013
Article Synopsis
- The study aimed to explore how multi-drug resistant Klebsiella pneumonia (MDR-KPN) develops resistance to quinolone antibiotics.
- A total of 47 MDR-KPN strains from six hospitals in China were analyzed for specific mutations and resistance genes responsible for quinolone resistance using PCR and DNA sequencing.
- The findings revealed high mutation rates in genes related to quinolone resistance, identified novel genetic variants, and marked the first global report of the qnrS4 variant.
Article Synopsis
- * Both phenotypic testing and PCR confirmed that all strains produced carbapenemases, specifically the bla(KPC) gene, with a 100% positivity rate.
- * The outbreak was linked to the bla(KPC-2) subtype, indicating it as a major factor in the resistance to carbapenem antibiotics within that hospital.
[Emergence of 16S rRNA methylase gene rmtB in Klebsiella pneumoniae isolates from the inpatients in Zhejiang Province, China].
Zhonghua Liu Xing Bing Xue Za Zhi
September 2008
Article Synopsis
[Analysis on 168 rRNA methylase genes and aminoglycoside modifying enzymes genes in Enterobacter cloacae in China].
Zhonghua Liu Xing Bing Xue Za Zhi
April 2008
Objective: To investigate the 16S rRNA methylase genes and Aminoglycoside modifying enzymes (AMEs) genes in Enterobacter cloacae isolated from the People's Liberation Army 98th Hospital, Huzhou district, Zhejiang province, China.
Methods: 40 strains of Enterobacter cloacae were isolated from the inpatients between September, 2003 and November, 2004. 5 kinds of 16S rRNA methylase gene (including armA, rmtA, rmtB, rmtC and rmtD) and 9 kinds of AMEs gene [including aac (3)-I, aac(3)-II, aac(3)-III, aac(3)-IV, aac(6')-Ib, aac(6')-II, ant(3")-I, ant(2")-I and aph(3')-VI] were analyzed by PCR and verificated by DNA sequencing.
[Study on the molecular epidemiology of SHV type beta-lactamase-encoding genes of multiple-drug-resistant acinetobacter baumannii].
Zhonghua Liu Xing Bing Xue Za Zhi
May 2004
Article Synopsis
- * Researchers isolated 60 strains from hospitalized patients and used methods like microdilution and PCR to test for antibiotic resistance and identify the specific SHV gene sequences.
- * They found that 30% of the strains carried the SHV beta-lactamases resistant gene, specifically the SHV-12 subtype, marking the first global report of this subtype related to an outbreak in a hospital setting.