The Foot-and-Mouth Disease Virus Lb Protease Cleaves Intracellular Transcription Factors STAT1 and STAT2 to Antagonize IFN-β-Induced Signaling.

Foot-and-mouth disease virus (FMDV) is the causative agent of foot-and-mouth disease, one of the most highly infectious animal viruses throughout the world. The JAK-STAT signaling pathway is a highly conserved pathway for IFN-β-induced antiviral gene expression. Previous studies have shown that FMDV can strongly suppress the innate immune response.

FMDV 3A Antagonizes the Effect of ANXA1 to Positively Modulate Viral Replication.

The RIG-I-like receptor signaling pathway is crucial for producing type I interferon (IFN-I) against RNA viruses. The present study observed that viral infection increased annexin-A1 (ANXA1) expression, and ANXA1 then promoted RNA virus-induced IFN-I production. Compared to ANXA1 wild-type cells, ANXA1 knockout cells showed IFN-β production decreasing after viral stimulation.

[A clinical efficacy and safety study on coronary heart disease and angina treatment with Puerarin Injection].

Objective: To observe the clinical efficacy and safety of Puerarin Injection treatment on angina pectoris.

Methods: 388 patients with angina pectoris, enrolled to Tianjin Fourth Central Hospital during January 2009 and February 2011 were selected and randomly divided into treatment or control groups with 194 patients of each. Based on the conventional therapy program, one group was given Puerarin Injection as treatment group while, the other was given with Danshen Injection as control group.

[Clinical studies on different coronary artery interventional therapies through femoral artery or radial artery approaches].

Objective: To compare the clinical efficacies regarding femoral artery or radial artery approaches on coronary artery interventional therapies.

Methods: 360 patients were randomly divided into intervention group via femoral artery (TFI) or transradial coronary intervention (TRI) group. Postoperative observation on the two said groups of patients with vascular lesion characteristics, feasibility factors (success rate of interventional therapy puncture, time of operation and hospitalization) and complications, were made.