Publications by authors named "Zhi-jun Xie"
Article Synopsis
- Rheumatoid arthritis is a chronic autoimmune condition that involves thickening of the synovial membrane and damage to cartilage, prompting researchers to explore quercetin, a flavonoid, as a potential treatment.
- The study utilized a collagen-induced arthritis model in rats, administering quercetin for four weeks to assess its impact on arthritis symptoms, inflammation, and underlying metabolic processes within synovial cells.
- Results showed that quercetin significantly improved arthritis symptoms and reduced inflammation markers in rats, suggesting it may help protect against joint damage by affecting specific signaling pathways.
Jiedu-Quyu-Ziyin Fang (JQZF) is a formula that has been empirically used for the treatment of SLE in clinical practice. JQZF has become an approved hospital prescription in China. Fifteen MRL/lpr mice were randomly divided into three groups: Model, JQZF, and JQZF + GC, with five mice in each group.
View Article and Find Full Text PDFEthnopharmacological Relevance: Jiedu-Quyu-Ziyin Fang (JQZF) is a new herbal formula improved based on "Sheng Ma Bie Jia Tang" in the Golden Chamber, has been proved to be effective in the treatment of SLE. The ability of JQZF to prevent lymphocyte growth and survival has been demonstrated in earlier investigations. However, the specific mechanism of JQZF on SLE has not been fully investigated.
View Article and Find Full Text PDFObjective: To evaluate the efficacy and safety of tofacitinib in combination with methotrexate (MTX) versus MTX monotherapy in patients with active rheumatoid arthritis (RA).
Methods: Trials were identified from four electronic databases: PubMed, Web of science, Cochrane Library and EMBASE from inception to April 2022. Two independent reviewers evaluated each database to scan the title, abstract and keywords of each record retrieved.
To clarify the mechanism of triptolide (TP) in alleviating the conditions underlying SLE. Eight-week-old MRL/lpr mice were randomly divided into a model group ( = 5), low-dose TP (TP-L) group ( = 5), and high-dose TP (TP-H) group ( = 5). Mice in these groups were gavaged with normal saline, low-dose TP solution, and high-dose TP solution for 8 weeks, respectively.
View Article and Find Full Text PDFSevere Coronavirus Disease 2019 (COVID-19) is characterized by numerous complications, complex disease, and high mortality, making its treatment a top priority in the treatment of COVID-19. Integrated traditional Chinese medicine (TCM) and western medicine played an important role in the prevention, treatment, and rehabilitation of COVID-19 during the epidemic. However, currently there are no evidence-based guidelines for the integrated treatment of severe COVID-19 with TCM and western medicine.
View Article and Find Full Text PDF[The Expression of CD40/CD40L in MM Patients and Its Significance to the Prognosis of MM Patients].
Zhongguo Shi Yan Xue Ye Xue Za Zhi
February 2021
Objective: To explore the expression of CD40/CD40L in multiple myeloma(MM) patients and its influence on prognosis.
Methods: Thirty patients with MM treated in Cangzhou People's Hospital from May 2016 to June 2017 were selected and divided into MM group, then 30 healthy people with a physical examination in our hospital at the same time were selected as the normal group. The serum CD40/CD40L levels of the patients in the two groups was detected by flow cytometry, and its correlation with the lymphocyte population, pathological grade and prognostic significance of MM patients was anaysis.
Background: We evaluated the clinical applications of the reconstruction of postoperative defects of the oral cavity using contralateral submental artery flaps.
Methods: A retrospective study of 18 patients with postoperative intraoral cancer defects reconstructed with contralateral submental artery perforator flaps between October 2018 and October 2019 in our department was conducted. The defect area, flap size, and complications were evaluated.
To mine the medication rules of herbal prescriptions for gout caused by heat-damp accumulation syndrome, and explore the possible mechanism of the core herbs, we collected the relevant literature of gout caused by heat-damp accumulation syndrome in CNKI, medication rules of herbal prescriptions are analyzed by using TCMISS(V2.5) software, and the compatibility of core drugs and new prescriptions were mined.KEGG pathway analysis was performed by BATMAN-TCM, an online analysis tool, and the potential signaling pathways of core drugs compatibility to treat gout caused by heat-damp accumulation syndrome were revealed.
View Article and Find Full Text PDFObjective: To investigate the effect of Lang-chuang-ding Decoction (, LCD) on the expression of DNA methylation of CD70 gene promoter in peripheral blood mononuclear cells (PBMCs) of females with systemic lupus erythematosus (SLE).
Methods: PBMCs isolated from female patients with SLE or healthy donors were cultured and treated with LCD medicated serum or normal serum for 24 or 48 h. The mRNA expressions of CD70 gene in PBMCs were detected by reverse transcription polymerase chain reaction (PCR); the DNA methylation of the CD70 gene promoter region was detected by methylation-specific PCR.
Effects of agkistrodon in different dosage forms on collagen-induced arthritis in rats.
Chin J Integr Med
December 2016
Objective: To determine the effective dosage and formulation of agkistrodon in collagen-induced arthritis (CIA) rats.
Methods: CIA was induced by injection of collagen in complete/incomplete Freund's adjuvant. Agkistrodon decoction, agkistrodon powder, and agkistrodon wine were administered daily starting from the onset of arthritis.
[Study on the regulation of Jiedu Quyu Zishen Recipe on glucocorticoid receptor alpha in the renal tissue of MRL/lpr mice].
Zhongguo Zhong Xi Yi Jie He Za Zhi
November 2011
Article Synopsis
- The study investigates how the Jiedu Quyu Zishen Recipe (JQZR) impacts the glucocorticoid receptor alpha (GRalpha) signaling in the kidneys of MRL/lpr mice, which are used as a model for renal injury.
- Thirty MRL/lpr mice were divided into three groups for treatment comparisons and a normal control group was included, with methods like HE staining and PCR used to analyze renal tissue changes and GRalpha expression.
- Results show that JQZR improved kidney injury by increasing GRalpha expression and its binding strength to cyclophilin A, indicating a potential therapeutic effect of the recipe in renal damage.
Article Synopsis
- The study investigates the impact of three Chinese herbal antidotes on the expression of RANTES, a gene associated with immune response, in MRL/lpr mice.
- Fifty-four mice were divided into nine groups and treated with various combinations of the herbs or prednisone over 12 weeks, measuring RANTES levels through ELISA and RT-PCR at the end.
- Findings show that while prednisone significantly reduced RANTES levels, the combination of all three herbal antidotes had the greatest inhibitory effect compared to individual treatments.
[Relationship between TCM syndrome type and expression of human leucocyte antigen DR gene in patients with systemic lupus erythematosus].
Zhongguo Zhong Xi Yi Jie He Za Zhi
June 2008
Objective: To explore the expression of human leucocyte antigen DR (HLA-DR) gene in peripheral blood mononuclear cells (PBMCs) of systemic lupus erythematosus (SLE) patients of various TCM syndrome types in order to seek an objective index for syndrome differentiation of SLE.
Methods: SLE patients were sorted into various syndrome types by TCM syndrome differentiation, i. e.