Publications by authors named "Zhi-hua Tu"

We demonstrated a TEM mode orthogonal dual-slab Yb:KG(WO)(Yb:KGW) laser oscillator with high average power. Polarization anisotropy of thermal lenses was investigated and alleviating the astigmatism based on orthogonal dual-slab. In addition, the laser polarization was directly controlled by adjusting the net gain of the two crystals.

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We demonstrated a deep-red laser source by intracavity frequency-doubled crystalline Raman laser for the first time, to the best of our knowledge. The actively -switched 1314 nm : laser was first converted to the eye-safe Raman laser using a () (KGW) crystal, which was subsequently frequency-doubled in a bismuth borate crystal. Benefiting from the KGW bi-axial properties, the deep-red laser source was able to lase separately at two different spectral lines at 730 and 745 nm.

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We demonstrated a narrowband eye-safe intracavity Raman laser by incorporating a fused silica etalon into the fundamental resonator. The KGd(WO) (KGW) Raman laser was pumped by an actively Q-switched Nd:YLF laser at 1314 nm. Thanks to the KGW bi-axial properties, two distinct eye-safe Raman lasers operating at 1461 and 1490 nm were obtained separately by rotation of the KGW crystal.

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A single-longitudinal-mode crystalline Raman laser in the 1.7 µm wave band was reported for the first time, to the best of our knowledge. The Raman laser, which was intracavity-pumped by an actively -switched 1314 nm Nd:YLF laser, demonstrated the cascaded Stokes oscillation at 1715 nm.

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An actively Q-switched eye-safe orthogonally-polarized dual-wavelength intracavity Raman laser was demonstrated for the first time, to the best of our knowledge. The gain balanced dual-wavelength operation at 1314 and 1321 nm within an in-band pumped Nd:YLF laser was realized by slightly titling the cavity mirrors. Owing to the KGW bi-axial properties, two sets of simultaneous orthogonally-polarized dual-wavelength Raman lasers at 1470, 1490 nm and 1461, 1499 nm were achieved by simply rotating the KGW crystal for 90°, respectively.

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Article Synopsis
  • * 478 individuals were found to carry thalassemia gene mutations, leading to a gene-carrying rate of 13.72%, with α-thalassemia being the most common type at 9.56%.
  • * The findings suggest a high incidence of thalassemia in Ding'an, highlighting the need for government action to enhance screening efforts to prevent congenital thalassemia.
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Objective: To investigate the genetic carrier rate of thalassemia and its gene mutation types as well as the distribution characteristics among the people in Lingshui Li autonomous county of Hainan province, so as to provide the basis for making the prevention programs of thalassemia in administrative departments.

Methods: Samples were collected from couples undergoing premarital and pregestational screenings, in which the positive ones in preliminary screening were further tested by genetic diagnoses and the genotypes were analyzed.

Results: The rate of thalassemia gene carriers was 19.

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In this Letter, the frequency expansion of an orthogonally polarized dual-wavelength laser, based on the cascaded stimulated Raman scattering, was demonstrated for the first time, to the best of our knowledge. The dual-wavelength fundamental laser generated from two separate Nd:YLF crystals was free of gain competition. Integrating the benefit of the two different orthogonally polarized Raman gain peaks in the KGd(WO) (KGW) crystal, two sets of first-Stokes orthogonally polarized dual-wavelength Raman lasers were first achieved by rotating the Raman crystal for 90°.

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Array comparative genomic hybridization (array-CGH), which facilitates to detect unbalanced reciprocal translocation and allows screening aneuploidy for chromosomes, has been repeatedly verified to be valid for diagnosis of translocations in preimplantation human embryos. Currently, the main microarrays used for CGH are bacterial artificial chromosome (BAC)-based arrays. Compared with the BAC-based arrays, oligonucleotide (oligo)-based arrays have a relatively higher resolution and optimal coverage particularly in the subtelomeric regions.

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In order to explore the variation of CO2 concentration and soil respiration in soil profile, the nondispersive infrared (NDIR) spectroscopy technique was applied to continually estimate the soil CO2 concentration in different soil layers (the humus horizon, A-, B-, C-horizon) in situ. The main instrument used in this experiment was silicon-based nondispersive infrared sensor, which could work in severe environment. We collected the Measurement value by NDIR spectroscopy technique throughout 2013.

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  • This study explored the connection between the expression of the survivin gene, an apoptotic inhibitor, and prognosis in nasopharyngeal carcinoma patients.
  • Survivin protein and mRNA levels were significantly higher in nasopharyngeal carcinoma samples (79.5% and 75%, respectively) compared to chronic nasopharyngitis, suggesting its potential role in cancer progression.
  • The study concluded that higher survivin expression correlates with shorter survival times, indicating its importance for both understanding disease development and improving prognosis.
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Objective: To investigate the relationship between survivin mRNA and protein expression and nasopharyngeal carcinoma (NPC).

Methods: Survivin mRNA and protein were detected by in situ hybridization and immunohistochemical S-P staining respectively.

Results: Among 64 cases of NPC, 42 cases (65.

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Synopsis of recent research by authors named "Zhi-hua Tu"

  • - Zhi-Hua Tu's recent research primarily focuses on advancements in laser technology, specifically within the realm of crystalline Raman lasers and their applications, demonstrating methods to increase efficiency, power, and safety in laser systems.
  • - Several noteworthy studies introduced novel laser configurations, such as orthogonal dual-slab Yb:KGd(WO) laser oscillators and eye-safe narrowband intracavity Raman lasers, which leverage unique properties of materials like KGW to achieve distinct operational functionalities and improved performance metrics.
  • - Additionally, Tu has explored genetic studies related to thalassemia carrier screening among couples in Hainan province, providing critical data on carrier rates, genetic types, and implications for health strategies in reproductive planning.