Publications by authors named "Zhi-hua Shen"
Article Synopsis
- The study focuses on how the surface protein corona (PC) of nanomaterials, particularly nano-FeO surfaces, affects their biological identity, highlighting the need to characterize these PCs in situ.
- Researchers used advanced techniques like time-limited proteolysis and mass spectrometry to analyze the spatial layout and molecular orientation of proteins in the PC over different time intervals.
- They discovered various protein interactions primarily driven by charge complementarity and that certain structural conformations of proteins change due to nanoparticle interactions, providing new insights into how PCs form.
Background: This study explored the feasibility of using EEG gamma-band (30-49 Hz) power as an index of cue-elicited craving in METH-dependent individuals.
Methods: Twenty-nine participants dependent on methamphetamine (METH) and 30 healthy participants were instructed to experience a METH-related virtual reality (VR) social environment.
Results: Individuals with METH dependence showed significantly stronger self-reported craving and higher gamma power in a VR environment than healthy individuals.
Background: Social cognition and interaction training (SCIT) is a psychosocial intervention program for patients with psychosis, designed to improve their social functioning by improving social cognition. Although the feasibility and efficacy of SCIT have been verified, patients with schizophrenia tend to suffer from motivational deficits and low treatment adherence. It has been suggested that using virtual reality (VR) technology might be effective in addressing these issues.
View Article and Find Full Text PDFThe present work developed a virtual reality (VR) counterconditioning procedure (VRCP), and investigated its efficacy in treatment of cue-induced craving in individuals with methamphetamine (METH) dependence. In study 1, thirty-one patients diagnosed with METH dependence received VRCP, while twenty-nine METH-dependent patients in waiting-list group did not. In study 2, the VRCP was computerized as a VR treatment system.
View Article and Find Full Text PDFBackground: Epstein-Barr virus-encoded LMP1 plays a critical role in the carcinogenesis of nasopharyngeal carcinoma (NPC), but the mechanism remains elusive. We aimed to analyze the expression and clinical pathological significance of provirus integration site for Moloney murine leukemia virus 1 (Pim1) in clinical NPC, and to elucidate the effect of LMP1 on Pim1 expression and its mechanism.
Methods: Immunohistochemical staining was used to detect the expression of Pim1 in clinical NPC tissues and control nasopharyngeal chronic inflammation (NPI) tissues, and the correlation between Pim1 and clinical parameters of NPC patients was analyzed.
In the present study, we developed a methamphetamine (METH)-related virtual social environment to elicit subjective craving and physiological reactivity. Sixty-one male patients who were abstinent from METH use and 45 age-matched healthy males (i.e.
View Article and Find Full Text PDFBackground: Attention ability can be subdivided into three functionally independent networks, i.e., alerting network, orienting network, and executive network.
View Article and Find Full Text PDFIn social interaction, Theory of Mind (ToM) enables us to construct representations of others' mental states, and to use those representations flexibly to explain or predict others' behavior. Although previous literature has documented that schizophrenia is associated with poor ToM ability, little is known about the cognitive mechanisms underlying their difficulty in ToM use. This study developed a new methodology to test whether the difficulty in false-belief-use might be related to deficits in perspective-switching or impaired inhibitory control among 23 remitted schizophrenia patients and 18 normal controls.
View Article and Find Full Text PDFArticle Synopsis
- * Heparanase expression is higher in the SGC-7901 gastric cancer cell line compared to MGC-803, and silencing heparanase reduces both migration and invasion in SGC-7901 cells.
- * Increasing heparanase in MGC-803 cells promotes their migration and invasion, with these processes linked to the activation of signaling pathways involving Src and p38 kinases.
Objective: To explore the role of proto-oncogene Pim-1 in the proliferation and migration of nasopharyngeal carcinoma (NPC) cells.
Methods: Pim-1 expressions in NPC cell lines CNE1, CNE1-GL, CNE-2Z and C666-1 were examined by RT-PCR, western blotting and immunoflucesence, respectively. After CNE1, CNE1-GL and C666-1 cells were treated with different concentrations of Pim-1 special inhibitor, quercetagetin, the cell viability, colony formation rate and migration ability were analyzed.
Background & Objective: Ezrin, a cytoskeleton-related protein, contributes to the invasion and metastasis of tumors; our previous study had also shown that Epstein-Barr virus latent membrane protein 1 (EBV-LMP1) can promote the metastasis of nasopharyngeal carcinoma (NPC) cells. This study was to investigate whether EBV-LMP1 could change the expression of Ezrin and the role of Ezrin on the metastasis of NPC cells.
Methods: The expression of EBV-LMP1 and Ezrin in NPC cell lines CNE1 (well differentiated NPC cell line) and CNE1-GL (CNE1 cells stably transfected with EBV-LMP1) were detected by SP immunohistochemistry and Western blot.