Publications by authors named "Zhi-hong Zou"

Multidrug resistance in cancer is a major cause of failure in cancer chemotherapy. In search of new compounds with strong reversal activity and simple molecular structure, we have synthesized a series of compounds in which different substituents were linked to the 2-position of the 6,7-dimethoxy-1-(3,4-dimethoxybenzyl)- tetrahydroisoquinoline system. Compounds were analyzed for their cytotoxicity by MTT in K562 cell line in vitro, all of the derivatives exhibited little cytotoxic activity.

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5-Fluoro-1H-indole-3-carb-oxy-lic acid.

Acta Crystallogr Sect E Struct Rep Online

January 2012

In the title compound, C(9)H(6)FNO(2), the carboxyl group is twisted slightly away from the indole-ring plane [dihedral angle = 7.39 (10)°]. In the crystal, carboxyl inversion dimers linked by pairs of O-H⋯O hydrogen bonds generate R(2) (2)(8) loops and N-H⋯O hydrogen bonds connect the dimers into (10[Formula: see text]) sheets.

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Multidrug resistance in tumor cells poses a major obstacle to efficient chemotherapy. Several types of agents have been recognized as multidrug resistance inhibitors, among which the tetrahydroisoquinolines is the most studied. In current study 16 furoxan-based nitric oxide-releasing derivatives of tetrahydroisoquinoline were synthesized.

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Phytochemical investigation of the ethanol extract of Pedicularis kansuensis Maxim. led to the isolation of one new triterpenoid and two new phenylpropanoid glycosides, along with ten known compounds. Their structures were established by extensive 1D and 2D NMR, as well as other spectrum analysis.

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The racemic title compound, C(14)H(12)ClNO, contains two mol-ecules in the asymmetric unit. The dihedral angles between the phenyl and benzene rings are 84.03 (15) and 83.

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The problem that the present sediment theory does not consider sludge recirculation effect on the efficiency of particle settling is studied. Based on the longitudinal mixing settling theory, an imperfect sediment model that takes reflux ratio in consideration is built. According to the established model, the study analyzes the effect of sludge recirculation taken by suction dredge on particle setting, in horizontal sedimentation tank.

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Considering the difficulty of fuzzy synthetic evaluation method in calculation of the multiple factors and ignorance of the relationship among evaluating objects, a new weight evaluation process using entropy method was introduced. This improved method for determination of weight of the evaluating indicators was applied in water quality assessment of the Three Gorges reservoir area. The results showed that this method was favorable for fuzzy synthetic evaluation when there were more than one evaluating objects.

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