Comparison of biliary protein spectrum in gallstone patients with obesity and those with normal body weight.

Background: Obesity is a common public health issue and is currently deemed a disease. Research has shown that the risk of gallstones in individuals with obesity is elevated. This study aimed to explore the bile proteomics differences between cholelithiasis patients with obesity and normal body weight.

[Determination of 15 halogenated polycyclic aromatic hydrocarbons in aquatic products by stable isotope dilution coupled with gas chromatography-triple quadrupole mass spectrometry].

Halogenated polycyclic aromatic hydrocarbons (H-PAHs), including chlorinated polycyclic aromatic hydrocarbons (Cl-PAHs) and brominated polycyclic aromatic hydrocarbons (Br-PAHs), are compounds in which one or more hydrogen atoms replaced by chlorine or bromine atoms. These compounds are not only difficult to degrade but also highly fat soluble and toxic. They are a new type of high-risk organic pollutants with structures similar to those of dioxins, and their toxicity is even higher than that of the parent polycyclic aromatic hydrocarbons (PAHs).

prevents high-fat diet-induced non-alcoholic fatty liver disease in rats by inhibiting expression the TLR4/MyD88 and the phosphorylation of NF-κB.

Context: Franch. (Gentianaceae) is a source of the traditional Tibetan medicine, ZangYinChen, and is used to treat chronic hepatitis and many types of jaundice.

Objective: This study explored the therapeutic effects and mechanism of on non-alcoholic fatty liver disease in diet-induced hypercholesterolaemia.

Tripartite Motif-Containing 44 is Involved in the Tumorigenesis of Laryngeal Squamous Cell Carcinoma, and its Expression is Downregulated by Nuciferine.

Tripartite motif-containing 44 (TRIM44) was reported to be involved in the tumorigenesis of several tumors, but its function in laryngeal squamous cell carcinoma has not been investigated yet. In the present study, we aimed to elucidate the function of TRIM44 in laryngeal squamous cell carcinoma, and identify the compounds which could inhibit TRIM44 expression. Our results showed that TRIM44 was upregulated in tumor tissues and cell lines of laryngeal squamous cell carcinoma.

Asparaginyl endopeptidase enhances pancreatic ductal adenocarcinoma cell invasion in an exosome-dependent manner and correlates with poor prognosis.

Pancreatic cancer is one of the most lethal types of cancer; owing to low early detection rates and high metastasis rates, it is associated with an extremely poor prognosis. Therefore, a better understanding of the molecular mechanisms that underlie its metastasis and the identification of potential prognostic biomarkers are urgently required. Although high expression levels of asparaginyl endopeptidase (AEP) have been detected in various types of solid tumor, the expression and functions of AEP in pancreatic carcinomas have yet to be determined.

[Research on Rapid and Non-Destructive Identification of Aging Wheat Based on ATR-Terahertz Spectroscopy Combined with PLS-DA].

In this research, the terahertz spectra data of the aging wheat processed under manual control environment by ATR accessory were collected. After the data diversity based on the composite score by PCA, the non-destructive identification models of aging wheat were developed by PLS-DA algorithm. The results showed that for the absorption coefficient spectrum, the accuracy of the experimental group, control group of the calibration set and cross validation set were 84.

Impacts of exposure to 900 MHz mobile phone radiation on liver function in rats.

Objective: To study the impacts of exposure to electromagnetic radiation (EMR) on liver function in rats.

Methods: Twenty adult male Sprague-Dawley rats were randomly divided into normal group and radiated group. The rats in normal group were not radiated, those in radiated group were exposed to EMR 4 h/ d for 18 consecutive days.

[Reason analysis of inadaptability and its correction research on the authenticity identification model of West Lake Longjing tea based on LVF micro-NIR spectrometer].

In the present paper, the micro-NIR spectrometer with the splitter of linear variable filter was used to develop the recognition models of the West Lake Longjing tea and the ordinary flat tea of the year 2012 and 2013. The NIR spectral data of different years and different storage times were decomposed by PCA algorithm. The PLS-DA models were developed by the representative samples selected by the mathematical characteristics of PCA-scores' distribution in order to analyze the reason for the inadaptability of the models according to mathematical principles and find out the solution for its correction.

Upregulation of miR-1280 expression in non-small cell lung cancer tissues.

Background: Non-small cell lung cancer (NSCLC) is a prolific and high-mortality disease with few effective treatments. Although the detection and surgical techniques for NSCLC continue to advance, the survival rate for the patients with NSCLC remains poor. Enhanced predictive biomarkers such as microRNAs (miRNAs) are needed at the time of diagnosis to better tailor therapies for patients.

Feasibility of β-sheet breaker peptide-H102 treatment for Alzheimer's disease based on β-amyloid hypothesis.

β-amyloid hypothesis is the predominant hypothesis in the study of pathogenesis of Alzheimer's disease. This hypothesis claims that aggregation and neurotoxic effects of amyloid β (Aβ) is the common pathway in a variety of etiological factors for Alzheimer's disease. Aβ peptide derives from amyloid precursor protein (APP).

Statistical analysis of sudden chemical leakage accidents reported in China between 2006 and 2011.

According to the data from authoritative sources, 1,400 sudden leakage accidents occurred in China during 2006 to 2011 were investigated, in which, 666 accidents were used for statistical characteristic abstracted with no or little damage. The research results were as follows: (1) Time fluctuation: the yearly number of sudden leakage accidents is shown to be decreasing from 2006 to 2010, and a slightly increase in 2011. Sudden leakage accidents occur mainly in summer, and more than half of the accidents occur from May to September.

Endothelin receptors in augmented vasoconstrictor responses to endothelin-1 in chronic intermittent hypoxia.

Chronic intermittent hypoxia (CIH) contributes to the development of cardiovascular diseases in patients with obstructive sleep apnoea. Many studies have shown an association between increased circulating endothelin (ET)-1 levels and CIH. The aim of the present study was to determine the role of ET receptors in altered aortic function in an animal model of CIH.

[Research on the quantitative determination of lime in wheat flour by near-infrared spectroscopy].

The safety of wheat flour is always focused by all quarters of society. Based on comparing the feature of NIR spectra of calcium oxide, calcium hydroxide and calcium carbonate in this research, the diffuse reflection NIR spectra of the wheat flour samples with different content of calcium oxide, calcium hydroxide and calcium carbonate mixed in were collected. The calibration models of lime and calcium carbonate were developed by partial least square algorithm, with the validation method of cross validation.

[Geometric distortion correction for hyperspectral image using a rotating scan reflector].

Offner imaging spectrometer is a kind of pushbroom imaging system. Hyperspectral images acquired by Offner imaging spectrometers require relative motion of sensor and scene that is translation or rotation. Via rotating scan with a reflector at the front of sensor's len, large objects can be entirely captured.

[Analysis of heavy metal in soil with portable X-ray fluorescence spectrometry].

The concentrations of main heavy metal pollutants (Cu, Zn, Pb, Cr and As) in soil were tested by NITON XL3 600 portable X-ray fluorescence spectrometry (PXRF). The results showed that the minimum? detection limits for elements Cu, Zn, Pb, Cr and As were 23.96, 11.

Long-term administration of fasudil improves cardiomyopathy in streptozotocin-induced diabetic rats.

Inhibition of Rho kinase (ROCK) has been shown to improve diabetic-related disorders. In this study, the cardio-protective effects and potential mechanisms of fasudil, a selective ROCK inhibitor, on diabetic cardiomyopathy were investigated in a streptozotocin (STZ)-induced diabetic rat model. Eight weeks after diabetes was induced by a single tail vein injection of 60 mg/kg STZ, rats were administered long-term fasudil or captopril as a control over a four-week period.

[Comparative research on the NIR and MIR micro-imaging of two similar plastic materials].

The NIR/MIR micro-imaging can supply not only the information of spectra, but also the information of spacial distribution of the sample, which is superior to the traditional NIR/MIR spectroscopy analysis. In the present paper, polyethylene and parafilm, with similar appearances, were regarded as the research objects, of which the NIR/MIR micro-imaging was collected. Chemical imaging (CI) and compare correlation imaging were carried out for the two materials respectively to discuss the imaging methods of the two materials.

[FTIR microspectroscopy and its progress in application].

FTIR microspectroscopy technique was born in the mid-nineties. The research on this technique has just began abroad, and this technology has not yet been widely recognized in China. It is a rapid, nondestructive testing technology, has the advantages of microdomain, visualization, high precision and high sensitivity.

Nuclear factor-κB and apoptosis in patients with intracerebral hemorrhage.

Studies using rat models have indicated that neuronal apoptosis is involved in the pathogenesis of intracerebral hemorrhage (ICH); however, the mechanism by which apoptosis occurs is unclear. In the present study, we aimed to quantify the number of nuclear factor-κB (NF-κB)-positive cells and apoptotic cells in specimens of middle temporal gyrus taken from 46 human subjects with hypertensive ICH. We also investigated the roles that intercellular adhesion molecule-1 (ICAM-1) and interleukin (IL)-1β play in apoptosis following ICH.

[Advance of the imaging spectral technique in diagnosis of the information of crop].

Labor intensive, time consuming, high technical requirements in operation and much affected by human factors is the limitation of diagnosing the crop information with conventional method, which could not make diagnosis real-time and rapid. Imaging spectral technique could simultaneously obtain the image and spectral information of crops. It could diagnose the growth and insects information of crop rapidly and non-destructively.

[Clinical and genetic characteristics of a patient with dyskeratosis congenita].

Objective: To analyze the clinical features and gene mutation of a patient with dyskeratosis congenita, who was admitted in our hospital for thrombocytopenia.

Method: The clinical and laboratory data of a 4 years and 10 months old boy were summarized. DKC1 gene was analyzed using PCR amplification and DNA sequencing.

trans-Di-μ-carbonyl-bis-{carbon-yl[η-2,3,4,5-tetra-methyl-1-(5-methyl-2-fur-yl)cyclo-penta-dien-yl]ruthenium(I)}(Ru-Ru).

In the crystal structure of the title compound, [Ru(2)(C(14)H(17)O)(2)(CO)(4)], each Ru(I) atom is connected to one end-on and two bridging carbonyl groups and one cyclo-penta-dienyl ring. The two Ru atoms are connected into binuclear complexes via two bridging carbonyl groups, forming four-membered rings which are located on centres of inversion. The Ru-Ru distance of 2.

trans-Di-μ-carbonyl-bis-{carbon-yl[η-2,3,4,5-tetra-methyl-1-(2-thien-yl)cyclo-penta-dien-yl]ruthenium(I)}(Ru-Ru).

The title compound, [Ru(2)(C(13)H(15)S)(2)(CO)(4)], is a centrosymmetric binuclear metal-carbonyl complex containing an Ru-Ru single bond [2.7511 (8) Å]. Each Ru(I) atom is coordinated by two bridging carbonyl ligands, one terminal carbonyl ligand and one η(5)-cyclo-penta-dienyl group.

Diaqua-bis(1,10-phenanthroline)magnesium dichromate(VI) 1,10-phenanthroline disolvate.

In the title compound, [Mg(C(12)H(8)N(2))(2)(H(2)O)(2)][Cr(2)O(7)]·2C(12)H(8)N(2), the cation and anion are situated on a twofold rotation axis. The Mg(II) ion is coordinated by four N atoms from two 1,10-phenanthroline ligands and two O atoms from coordinated water mol-ecules in a distorted octa-hedral geometry. Inter-molecular O-H⋯N and O-H⋯O hydrogen bonds and π-π inter-actions between the aromatic rings [shortest centroid-centroid separation = 3.