Mexicanolide limonoids from the seeds of with antimicrobial activity.

The methanol extract of the seeds of afforded two new mexicanolide limonoids, ivorensines A and B ( and ), together with one known compound, ruageanin D (). The structures of the isolated compounds were established based on 1 D and 2 D (H-H COSY, HMQC, and HMBC) NMR spectroscopy, in addition to high resolution mass spectrometry. The isolated limonoids were tested for antimicrobial potentials against 5 pathogenic microorganisms.

Effects of Integrative Neuromuscular Training Combined With Regular Tennis Training Program on Sprint and Change of Direction of Children.

Objective: The aim of this study was to investigate the effects of integrative neuromuscular training (NMT) on sprint and the ability to change direction for children who are between the ages of 7 and 8 and beginning to play tennis.

Methods: Thirty-two participants were randomized into a training group (TG;  = 16) and a control group (CG;  = 16). All participants attended tennis classes twice a week for a continuous 8 weeks.

Silencing Snail Reverses Epithelial-Mesenchymal Transition and Increases Radiosensitivity in Hypopharyngeal Carcinoma.

Purpose: Radioresistance in response to radiotherapy leads to cancer recurrence and poor survival in hypopharyngeal carcinoma patients. Previous studies indicate that ionizing radiation (IR) can induce epithelial-mesenchymal transition (EMT) that promotes the radioresistance, migration and invasiveness of tumors. The aim of this study was to explore the role of Snail in EMT and acquired radioresistance in hypopharyngeal carcinoma.

IL-37 attenuates allergic process via STAT6/STAT3 pathways in murine allergic rhinitis.

Allergic rhinitis (AR) is a common upper airway allergic disease caused by allergens triggering a type 2 immune response. The imbalance of CD4+ T cell subsets is the essential immunological feature of AR, which is mainly characterized by the predominance of T helper (Th) 2 cells. Recent studies indicated that the anti-inflammatory factor interleukin (IL)-37 is involved in the immune regulation of AR.

Increased expression of IL-1R8 and a possible immunomodulatory role of its ligand IL-37 in allergic rhinitis patients.

Allergic rhinitis (AR) is a chronic inflammatory airway disease that is caused by an abnormal T cell response. T helper (Th)-17 cells and Th2 cells are the CD4 T cell subsets implicated in the pathogenesis of AR. The suppression of excessive responses of these Th17 and Th2 cells has been reported to be an effective therapeutic approach to treat AR patients, and continuous efforts are being undertaken to find new methods to modulate the function of these cells.

Ovol2 gene inhibits the Epithelial-to-Mesenchymal Transition in lung adenocarcinoma by transcriptionally repressing Twist1.

Background: Associated with recent achievements in therapy for advanced lung adenocarcinoma, there will still be an unmet medical need for effective treatment of stage IIIb/IV, and the prognosis of lung cancer is not optimistic till now.

Objective: In order to obtain some essential evidences for a potential targeted therapy in lung adenocarcinoma, the effects of Ovol2 gene on Epithelial-to-Mesenchymal Transition (EMT) was observed and the probable mechanisms were analyzed.

Methods: Ovol2 expression was previously evaluated by immunochemistry in lung adenocarcinoma tissue, and Ovol2 was overexpressed by lentivirus infection in A549 cells.

[Research on Quantitative Method for the Determination of Carbon Isotopic Composition of CO2 with Micro-Laser Raman Spectroscopy].

In this study, a series of 12CO2/N2 and 13CO2/N2 binary mixtures with various molar fraction ratios were synthesized. It was found that the Raman peak area ratios were proportional to molar fraction ratios. The linearity of the working curves was very good.

ING5 inhibits epithelial-mesenchymal transition in breast cancer by suppressing PI3K/Akt pathway.

Epithelial-mesenchymal transition (EMT) is a crucial step in tumor progression and has an important role during cancer invasion and metastasis. The proteins of the inhibitor of growth (ING) candidate tumor suppressor family are involved in multiple cellular functions such as cell cycle regulation and apoptosis. ING5 is a member of the family.

MicroRNA expression profile of mature dendritic cell in chronic rhinosinusitis.

Objective: Chronic rhinosinusitis (CRS), which includes CRS without nasal polyposis (CRSsNP) and with nasal polyposis (CRSwNP), shows imbalance of helper T cells (Th) and regulatory T cells (Treg). The balance of Th and Treg cells is orchestrated by dendritic cells (DCs). Recent studies show functions of DCs can be regulated by microRNAs (miRNAs or miRs).