A Chinese Multi-Specialty Delphi Consensus to Optimize RAASi Usage and Hyperkalaemia Management in Patients with Chronic Kidney Disease and Heart Failure.

Objective Variations are present in common clinical practices regarding best practice in managing hyperkalaemia (HK), there is therefore a need to establish a multi-specialty approach to optimal renin-angiotension-aldosterone system inhibitors (RAASi) usage and HK management in patients with chronic kidney disease (CKD) & heart failure (HF).This study aimed to establish a multi-speciality approach to the optimal use of RAASi and the management of HK in patients with CKD and HF. Methods A steering expert group of cardiology and nephrology experts across China were convened to discuss challenges to HK management through a nominal group technique.

Identification of AKI signatures and classification patterns in ccRCC based on machine learning.

Background: Acute kidney injury can be mitigated if detected early. There are limited biomarkers for predicting acute kidney injury (AKI). In this study, we used public databases with machine learning algorithms to identify novel biomarkers to predict AKI.

[Effect of ligustilide on oxygen and glucose deprivation/reperfusion-induced mitochondria fission in PC12 cells].

This study aimed to investigate the effect and mechanism of ligustilide, the main active ingredient in Ligusticum wallichii, on mitochondria fission after PC12 cell injury induced by oxygen and glucose deprivation/reperfusion(OGD/R). In the experiment, an OGD/R model was established in vitro, and PC12 cells were pre-treated with ligustilide for 3 h, and then the cell viability was detected by CCK-8 method. The effect of different concentrations of ligustilide on the morphology of PC12 cells after OGD/R injury was observed under an inverted microscope.

New-onset glucose disorders in peritoneal dialysis patients: a meta-analysis and systematic review.

Background: Peritoneal dialysis (PD) patients are at high risk of developing glucose metabolism disturbance (GMD). The incidence and prevalence of new-onset GMD, including diabetes mellitus (DM), impaired glucose tolerance (IGT) and impaired fast glucose (IFG), after initiation of PD, as well as their correlated influence factors, varies among studies in different areas and of different sample sizes. Also, the difference compared with hemodialysis (HD) remained unclear.

Rosiglitazone affects lumen formation in MDCKII cell through regulating apico-basal polarity.

This study aimed to investigate the potential mechanisms underlying the effects of Rosiglitazone on the apico-basal polarity in renal epithelial cells. 3D-MDCK model was used to study the lumen formation and localization of polarity proteins at the early stage of the establishment of the apico-basal polarity. The calcium switch model, immunofluorescence staining and measurement of transmembrane electrical impedance are employed to investigate the epithelial apico-basal polarity including the development and maintenance of apical domains and the formation of tight junction.

Efficacy and safety of Changfu peritoneal dialysis solution: a multi-center prospective randomized controlled trial.

Background: A multi-center large scale study is needed to confirm the efficacy and safety of domestic peritoneal dialysis (PD) solutions. Some researchers believe that 6 L/d is enough for adequate dialysis, but there is no multi-center prospective study on Chinese population to confirm this. In this study, we evaluated the efficacy and safety of domestic PD solution (Changfu) and its difference between 6 L and 8 L dosage.

Autosomal dominant polycystic kidney disease with ectopic unilateral multicystic dysplastic kidney.

Background: Autosomal dominant polycystic kidney disease (ADPKD) is the most common hereditary renal disorder. In most cases, ADPKD similarly affects bilateral kidneys.

Case Presentation: Among the 605 ADPKD patients that were followed up by our center, we identified two male patients with unilateral ADPKD.

Scientific publications in nephrology and urology journals from Chinese authors in East Asia: a 10-year survey of the literature.

Background: Diseases of the kidneys and genitourinary tract are common health problems that affect people of all ages and demographic backgrounds. In this study, we compared the quantity and quality of nephrological and urological articles published in international journals from the three major regions of China: the mainland (ML), Hong Kong (HK), and Taiwan (TW).

Methods: Nephrological and urological articles originating from ML, TW, and HK that were published in 61 journals from 1999-2008 were retrieved from the PubMed database.

[Electron excitation temperature of hexagon pattern in argon discharge at atmospheric pressure].

The emission spectrum and the discharge current waveform of argon dielectric barrier discharge at atmospheric pressure were measured when the filaments self-organized in hexagon pattern by using a specially designed experimental setup. Electron excitation temperature of hexagon pattern was calculated using intensity ratio method. It was found that the electron excitation temperature is higher as the frequency of feeding voltage increases.

[Spectrum of dielectric barrier discharge at atmospheric pressure intensified by mixing a little argon].

In this paper, the spectrum of dielectric barrier discharge at atmospheric pressure was measured by using the special setup with two water electrodes. The variation of spectrum was studied when a little argon was mixed. Nitrogen molecular spectrum (C3 IIu(v' = 0 ) --> B3 IIg(v" = 0-4)) and nitrogen atomic spectrum(4d(4) D7/2 --> 3p(4)P1/2(0)) were found in the range of 300-800nm.

[Electron excitation temperature of argon dielectric barrier discharge at atmospheric pressure].

The electron excitation temperature was measured by the intensity ratio of two spectral lines in argon dielectric barrier discharge (DBD) at atmospheric pressure. The spectral range is from 690 to 800 nm. It is shown that all of the spectral lines are attributed to neutral Ar atoms.