Publications by Zhi-gang Nong

Publications by authors named "Zhi-gang Nong"

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[Effect of SUMO-1 on mitochondria subcellular localization of alpha-synuclein and its degradation via ubiquitin-proteasome system].

Tao Chen Xiao-ping Liao Guo-qiang Wen Zhi-gang Nong Feng Ouyang

Zhonghua Yi Xue Yi Chuan Xue Za Zhi

June 2010

Objective: To investigate the effect of sumoylation of alpha-synuclein by SUMO-1 on the mitochondria subcellular localization of alpha-synuclein and its degradation via ubiquitin-proteasome system.

Methods: Primers of wild-type, A53T pathogenic mutant and K96R mutant of human alpha-synuclein were designed to amplify the corresponding cDNAs without stop codon. The cDNAs were cloned into pGEM T-easy vector, analyzed by using enzyme mapping and DNA sequencing, and subcloned into pEGFP-N1 vector.

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- Zhi-gang Nong's research primarily focuses on the molecular mechanisms of proteins involved in neurodegenerative diseases, specifically the role of alpha-synuclein in mitochondrial function and degradation processes.
- One of his key studies investigates how SUMO-1 affects the localization of alpha-synuclein within mitochondria and how this influences its degradation through the ubiquitin-proteasome system.
- Through various molecular biology techniques, including cDNA cloning and sequencing, the research presents a comprehensive analysis of alpha-synuclein’s interactions and post-translational modifications, contributing to understanding its pathogenic role in disorders like Parkinson's disease.

Publications by authors named "Zhi-gang Nong"

[Effect of SUMO-1 on mitochondria subcellular localization of alpha-synuclein and its degradation via ubiquitin-proteasome system].

Synopsis of recent research by authors named "Zhi-gang Nong"