Publications by authors named "Zhi-feng Pan"
Plasma shows distinct metabolomic and proteomic signatures in response to combination therapy with lenvatinib and anti-programmed death-1 (PD-1) antibody in treating hepatocellular carcinoma (HCC). Here, we present a protocol for analyzing plasma proteomes from patients with HCC receiving combination therapy. We describe steps for interpreting mass spectrometry data by database searching using MaxQuant and filtering and processing database search outcomes.
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- The endocannabinoid system is a crucial biological network that regulates various bodily functions like pain, emotion, and memory through receptors like CB1 and CB2.
- These receptors are significant in pain regulation and are being studied in relation to acupuncture's pain-relieving effects.
- The paper reviews how acupuncture activates CB1 and CB2 receptors in different animal pain models (like inflammatory and neuropathic pain) to explore the mechanisms behind its analgesic properties.
Dentritic cells (DCs) dysfunction has been verified detrimental for sepsis and B and T lymphocyte attenuator (BTLA) is an immune-regulatory receptor shown to be associated with DCs dysfunction. However, the role of BTLA expression in myeloid DCs (mDCs) in neonatal sepsis is unknown. In the current study, we found BTLA-expressing mDCs were elevated in neonates with sepsis and the BTLA expression level in mDCs was positively correlated to the severity of sepsis.
View Article and Find Full Text PDF[Research on Early Diagnosis of Gastric Cancer by the Surface Enhanced Raman Spectroscopy of Human Hemoglobin].
Guang Pu Xue Yu Guang Pu Fen Xi
December 2015
Article Synopsis
- Early diagnosis significantly enhances treatment outcomes for gastric cancer patients, and Raman spectroscopy serves as a valuable tool for monitoring hemoglobin dynamics and diagnosing abnormalities.
- A novel silver colloid synthesized via microwave heating allows for the collection of high-quality Raman spectra from hemoglobin samples, revealing lower levels of specific amino acids in gastric cancer patients compared to healthy individuals.
- The research indicates that using Surface Enhanced Raman Spectroscopy (SERS) combined with multivariate analysis can effectively differentiate between healthy and cancerous groups with high sensitivity and specificity, suggesting a promising method for early gastric cancer diagnosis.