Publications by authors named "Zhi-fang Ying"
Article Synopsis
- The study investigates immune persistence after switching from trivalent oral poliovirus vaccine (tOPV) to a new immunization schedule (IPV and bOPV) since 2016.
- Blood samples were collected from 1104 participants at various ages to measure antibody levels against polioviruses.
- Results showed that while type 1 and type 3 antibody rates were similar across groups, the 2-specific antibody rates were much higher in the IPV-IPV-tOPV group compared to others, indicating some schedules did not effectively maintain immunity against poliovirus type 2.
To provide a basis for further optimization of the polio sequential immunization schedule, this study evaluated the effectiveness of booster immunization with one dose of bivalent oral poliovirus vaccine (bOPV) at 48 months of age after different primary polio immunization schedules. At 48 months of age, one dose of bOPV was administered, and their poliovirus types 1-3 (PV1, PV2, and PV3, respectively)-specific neutralizing antibody levels were determined. Participants found to be negative for any type of PV-specific neutralizing antibody at 24, 36, or 48 months of age were re-vaccinated with inactivated polio vaccine (IPV).
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- Two vaccination schedules combining inactivated polio vaccine (IPV) with oral polio vaccine (OPV) were compared to an OPV-only schedule in healthy infants to evaluate immunogenicity and safety.
- The study found that more than 99% of participants developed adequate polio antibody levels, with the IPV-OPV combinations showing comparable immunogenicity to the OPV-only group.
- The results suggested that administering IPV followed by OPV is an effective strategy, with antibody levels linked to the number of OPV doses received, and similar adverse event rates across all groups.
[Study on safety and immunogenicity of oral poliomyelitis attenuated live vaccine (human diploid cell)].
Zhongguo Yi Miao He Mian Yi
June 2010
Objective: To evaluate the safety and Immunogenicity of the Poliomyelitis vaccine (Human Diploid Cell) in > or =2 month-old children.
Methods: A random, blind and control trial, 1200 healthy children of 2-5 months old in Jiangsu province were administered OPV (HDC) vaccine and control vaccines. The antibody was tested by neutralization test.
[Effectiveness of inactivated poliomyelitis vaccine for primary vaccination].
Zhonghua Yu Fang Yi Xue Za Zhi
June 2009
Objective: To study the immunological effectiveness of inactivated poliomyelitis vaccine (IPV) for children's primary vaccination in China and to compare with the oral poliomyelitis vaccine (OPV) used in routine vaccination.
Methods: The 2-month-old children were randomly immunized with IPV and OPV, with 208 subjects in each group. The pre- and post-vaccination blood samples were collected.