Publications by authors named "Zhi-chao Zheng"
Glycolysis-related five-gene signature correlates with prognosis and immune infiltration in gastric cancer.
World J Gastrointest Oncol
July 2024
Background: Gastric cancer (GC) is one of the most common malignancies worldwide. Glycolysis has been demonstrated to be pivotal for the carcinogenesis of GC.
Aim: To develop a glycolysis-based gene signature for prognostic evaluation in GC patients.
Article Synopsis
- Gastrointestinal stromal tumors (GIST) are the most common type of mesenchymal tumors in the GI tract, with uncertain malignant potential, prompting the need for improved predictive models for recurrence-free survival (RFS).
- A study involving 254 patients who underwent surgery for GIST utilized radiomics and deep learning to create multiple predictive models, with a multimodal model showing the best performance in predicting RFS.
- The findings indicated significant differences in RFS between high and low-risk groups, suggesting a connection between tumor cell morphology and prognosis, thus supporting the use of advanced modeling techniques in clinical decision-making.
Article Synopsis
- This study examines how boron (B) supplementation affects the remodeling of plant cell walls (CW) in Citrus sinensis seedlings exposed to high levels of copper (Cu).
- The researchers found that adding B helped mitigate the harmful effects of Cu by lowering its concentrations in the plant's leaves and roots, thus promoting healthier growth.
- Techniques like Fourier transform infrared (FTIR) and X-ray diffraction (XRD) were used to show that certain components of the cell walls (such as pectin and cellulose) can bind to Cu, reducing its toxic effects on the plants.
Article Synopsis
- Researchers studied 'Xuegan' (Citrus sinensis) seedlings' response to manganese (Mn) in hydroponic conditions, finding that increased Mn supply decreased both Mn absorption and its translocation from roots to shoots.
- Without Mn, the seedlings increased the pH of the solution, but higher Mn levels reduced this alkalization and led to more secretion of root total phenolics, while pH dropped.
- Metabolomic analysis revealed that Mn-tolerant seedlings upregulated various phenolic and secondary metabolites, indicating a complex response mechanism to manage high Mn levels and maintain tolerance.
Article Synopsis
- Boron (B) helps citrus plants deal with toxic levels of copper (Cu), but the exact mechanism is not well understood.
- In a study with 'Xuegan' citrus seedlings, researchers explored how B affected the secretion of low molecular weight compounds (LMWCs) from roots and their concentrations in roots and leaves while exposing them to control (0.5 µM) and high (350 µM) Cu levels.
- The results showed that while Cu-stress increased the release of certain LMWCs, B didn't enhance this release and even reduced malate secretion; however, B increased the concentrations of some LMWCs in Cu-stressed roots, indicating an internal detoxification process for mitigating Cu-toxicity
An abnormality in the regulation of adenosine deaminase acting on RNA (ADAR) enzymes, which catalyzed adenosine-to-inosine (A-to-I) RNA editing, was closely associated with the highly aggressive biologic behavior and poor prognosis in many malignancies. In the present study, we aimed to investigate the relationship among transcript factors-microRNAs regulatory network, immune environment, and ADAR gene in colorectal carcinoma (CRC). The association among the expression levels of ADAR mRNA and copy number variation, methylation, and mutation status were comprehensively analyzed using cBioPortal, Wanderer, and UALCAN databases in CRC datasets.
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- Copper (Cu) excess is common in old Citrus orchards, and this study focused on understanding how this affects root exudates and plant tolerance to Cu in sweet orange seedlings.
- The research examined how varying Cu concentrations (0 to 5000 μM) impacted Cu uptake, root exudate composition, solution pH, and signs of stress in the plants.
- Findings revealed that lower Cu concentrations led to increased root alkalization and exudate release, which are critical for enhancing Cu tolerance, while higher concentrations resulted in higher Cu accumulation and greater stress indicators.
Article Synopsis
- In China, nitrogen deficiency in Citrus orchards leads to reduced yields and lower fruit quality, prompting a study on the metabolic responses of Citrus sinensis to N-deficiency.* -
- The experiment involved varying nitrogen concentrations supplied to 'Xuegan' seedlings over 10 weeks, revealing that N-deficiency influenced carbon and nitrogen distribution, enhancing root weight and nitrogen use efficiency while altering carbohydrate levels.* -
- Results showed that with N-deficiency, leaves had lower starch but higher sucrose ratios, while roots stored more starch, indicating adaptive metabolic shifts in response to nitrogen availability in the plants.*
Article Synopsis
- * Low pH negatively impacted photosynthesis by impairing light reaction and carbon fixation, leading to reduced carbon metabolism and ATP production, while some adaptive responses to phosphate and oxidative stress were observed.
- * Although low pH prompted certain antioxidant responses and gene expressions to mitigate damage, it ultimately disrupted the balance of reactive oxygen species, resulting in oxidative stress and potential damage to the leaves.
The objective was to construct a prognostic risk model of stomach adenocarcinoma (STAD) based on The Cancer Proteome Atlas (TCPA) to search for prognostic biomarkers. Protein data and clinical data on STAD were downloaded from the TCGA database, and differential expressions of proteins between carcinoma and para-carcinoma tissues were screened using the R package. The STAD data were randomly divided into a training set and a testing set in a 1:1 ratio.
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- Xuegan seedlings were exposed to different levels of copper (Cu) and boron (B) to study the effects of Cu-toxicity on plant growth and nutrient uptake over a 24-week period.
- Cu-toxicity resulted in increased Cu concentration in plant tissues, reduced uptake of essential nutrients, and significant root damage, which worsened the plants' overall health and function.
- Supplementation of boron was found to mitigate the harmful effects of Cu-toxicity by decreasing Cu uptake, improving nutrient balance and water status, and enhancing the plants' physiological performance, as indicated by better leaf function and photosynthesis measurements.
PubMed, ScienceDirect, Cochrane, Embase, Scopus, China National Knowledge Infrastructure (CNKI), Chinese Weipu, and Wanfang databases were searched to evaluate the effects of probiotics supplements on gastric cancer-related inflammatory factors. Parallel randomized controlled trials (RCTs) assessing the effects of prebiotics supplement on gastric cancer patients were included in the review. Compared with routine nutrition, meta-analysis shows that probiotics supplements reduce gastric cancer-related inflammation levels by mostly increasing the levels of cluster of differentiation 4 and greatly reducing the levels of interleukin-6.
View Article and Find Full Text PDFBackground: Various surgical procedures have been described for gastrointestinal stromal tumors (GISTs) at the esophagogastric junction (EGJ) close to the Z-line. However, surgery for EGJ-GIST involving Z-line has been rarely reported.
Aim: To introduce a novel technique called conformal resection (CR) for open resection of EGJ-GIST involving Z-line.
Background: Gastric cancer (GC) accounts for high mortality. RNA methylation has recently gained interest as markers in specific tumors. This study aimed to uncover the function of the roles of 25 RNA methylation regulators in GC.
View Article and Find Full Text PDFIntroduction: Diabetic nephropathy (DN) has become an increasing threat to health, and inflammation and fibrosis play important roles in its progression. Wogonin, a flavonoid, has been proven to suppress inflammation and fibrosis in various diseases, including acute kidney injury. This study aimed at investigating the effect of wogonin on diabetes-induced renal inflammation and fibrosis.
View Article and Find Full Text PDFThere are controversial indications for neoadjuvant chemotherapy (NAT) in the treatment of locally advanced gastric cancer (LAGC). Here, we aimed to identify indications for NAT based on pre-treatment clinicopathological and laboratory parameters. This study included a retrospective cohort of 1083 LAGC patients who had underwent radical D2 gastrectomy in the Cancer Hospital of China Medical University between 2012 and 2016.
View Article and Find Full Text PDFAim: Aberrantly expressed long non-coding RNAs (lncRNAs) are critical instigators of gastric cancer (GC) progression and metastasis. The ceRNA (competing endogenous RNAs) network is well-known in modulating tumor pathological and physiological processes. This research aims to determine the more effective molecular mechanisms of lncRNA PCGEM1 (prostate cancer gene expression marker 1).
View Article and Find Full Text PDFBackground: The age thresholds for differentiating young and elderly patients are still under debate. This study aimed to evaluate the cut-off age for differentiating patients along with the prognostic value of age for operable gastric cancer (GC).
Methods: Patients diagnosed with resected gastric adenocarcinoma were identified from the National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) database (training cohort and internal validation cohort) and Liaoning Cancer Hospital (external validation cohort).
A SEER population analysis of stage IB resected gastric cancer: who can benefit from adjuvant therapy?
Scand J Gastroenterol
February 2020
The benefit of adjuvant therapy (AT) remains controversial in stage IB gastric cancer (GC). This study aimed to offer a reference for the rational indications of AT. We retrospectively included 1216 stage IB GC who experienced curative surgery from the SEER database between 2004 and 2015.
View Article and Find Full Text PDFBackground: Gastric cancer (GC) is the most common and aggressive cancer of the digestive system and poses a serious threat to human health. Since genes do not work alone, our aim was to elucidate the potential network of mRNAs and noncoding RNAs (ncRNAs) in this study.
Methods: Transcriptome data of GC were obtained from TCGA.
Background: The impact of signet ring cell carcinoma (SRC) on gastric cancer patients' prognosis remains controversial. The aim of this study was to evaluate the clinicopathological characteristics and prognosis of SRC carcinoma and adenocarcinoma (AC) in patients with gastric cancer (GC).
Methods: An electronic search of SRC and AC cases from 2004 to 2015 was conducted within the National Cancer Institute Surveillance, Epidemiology, and End Results (SEER) database.
, a Novel Hypoxia Target Gene Related to Gastric Cancer Invasion and Metastasis.
Biomed Res Int
January 2020
Gastric cancer (GC) is a common tumor-associated lethal disease, and invasiveness and metastasis are primary challenges in its clinical treatment. Hypoxia microenvironment cannot be ignored in the process of metastasis. Hypoxia inducible factor-1 (HIF-1) is the core component of the hypoxia signaling pathway.
View Article and Find Full Text PDFN-Methyladenosine (mA) is the most common posttranscriptional modification of RNA and plays critical roles in cancer pathogenesis. However, the biological function of long noncoding RNA (lncRNA) methylation remains unclear. As a demethylase, ALKBH5 (alkylation repair homolog protein 5) is involved in mediating methylation reversal.
View Article and Find Full Text PDFAim: To detect significant clusters of co-expressed genes associated with tumorigenesis that might help to predict stomach adenocarcinoma (SA) prognosis.
Methods: The Cancer Genome Atlas database was used to obtain RNA sequences as well as complete clinical data of SA and adjacent normal tissues from patients. Weighted gene co-expression network analysis (WGCNA) was used to investigate the meaningful module along with hub genes.