Publications by authors named "Zhi-chao Sun"
Unlabelled: Bone metastasis from breast cancer significantly elevates patient morbidity and mortality, making early detection crucial for improving outcomes. This study utilizes radiomics to analyze changes in the thoracic vertebral bone marrow microenvironment from chest computerized tomography (CT) images prior to bone metastasis in breast cancer, and constructs a model to predict metastasis.
Methods: This study retrospectively gathered data from breast cancer patients who were diagnosed and continuously monitored for five years from January 2013 to September 2023.
Article Synopsis
- Acute lung injury (ALI) and acute respiratory distress syndrome are serious conditions linked to an imbalance in macrophage polarization (M1/M2), with current treatments presenting limitations like side effects and poor delivery.
- Researchers developed a new inhalable nanomedicine called Ber-lipo, combining bergapten with DPPC liposomes, which demonstrated promising anti-inflammatory effects and maintained macrophage balance in preclinical tests.
- In a mouse model of ALI, Ber-lipo effectively targeted inflamed lungs, improved lung function and tissue integrity, alleviated symptoms, and suppressed key signaling pathways involved in the disease's progression.
Article Synopsis
- Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are serious, high-mortality conditions often linked to diseases like COVID-19, but existing treatments face limitations due to toxicity and administration challenges.
- This study introduces a new formulation called Pac@liposome (Pac-lipo), derived from a plant extract, which improves the solubility and distribution of the anti-inflammatory compound pachypodol to enhance treatment for ALI/ARDS.
- Experimental results show that Pac-lipo effectively reduces inflammation and lung injury in both lab tests and mouse models, outperforming the effects of pachypodol alone, and works by inhibiting key inflammatory pathways in the body.
Background: The combination of radiomics and diffusion tensor imaging (DTI) may have potential clinical value in the early stage of HIV-associated neurocognitive disorders (HAND).
Purpose: To investigate the value of DTI-based radiomics in the early stage of HAND in people living with HIV (PLWH).
Study Type: Retrospective.
Article Synopsis
- - There is growing public concern about the risks associated with increased X-ray examinations in medicine, yet some doctors may not fully understand these dangers.
- - The study focuses on strategies to minimize harm from X-ray exposure and aims to raise awareness about its risks, emphasizing the importance of reducing the frequency and dosage of X-ray tests.
- - Recommendations include using alternatives to X-rays when possible and carefully weighing the risks versus benefits when X-ray procedures are necessary, particularly for sensitive populations like children.
Article Synopsis
- Computed tomography (CT) is a widely used imaging method, but its radiation levels can vary based on factors like the body part being examined and the patient population.
- There is ongoing debate among researchers and physicians about the potential cancer risk associated with low-dose CT scans, highlighting the need for careful consideration of research contexts and patient exposure.
- The review article aims to educate healthcare professionals about the risks of low-dose CT radiation and encourage strategies to minimize unnecessary exposure to patients.
Type I interferon and apoptosis elicit multifaceted effects on host defense and various diseases, such as viral infections and cancers. However, the gene/protein network regulating type I interferon and apoptosis has not been elucidated completely. In this study, we selected grass carp () as an experimental model to investigate the modulation of RNASEK on the secretion of type I interferon and apoptosis.
View Article and Find Full Text PDFBackground: Transcranial alternating current stimulation (tACS) offers a new approach for adult patients with major depressive disorder (MDD). The study is to evaluate the efficacy and safety of tACS treating MDD.
Methods: This is an 8-week, double-blind, randomized, placebo-controlled study.
Background: Not all adults with chronic insomnia respond to the recommended therapeutic options of cognitive behavioral therapy and approved hypnotic drugs. Transcranial alternating current stimulation (tACS) may offer a novel potential treatment modality for insomnia.
Objectives: This study aimed to examine the efficacy and safety of tACS for treating adult patients with chronic insomnia.
Article Synopsis
- The study focuses on identifying specific QTL (quantitative trait loci) that influence grain size traits, which are crucial for both yield and quality in rice.
- Researchers used 12 different rice populations to analyze and narrow down the location of a previously mapped QTL on chromosome 10 that affects grain weight, length, and width.
- The results identified three distinct QTLs within the target region, with varying impacts on the traits, indicating a complex genetic network that regulates grain size in rice.
Circular RNAs (circRNAs) are covalently closed, conserved single-stranded transcripts that are produced from precursor mRNA (pre-mRNA) back-splicing. They could function as microRNA sponges, interfere with splicing and bind to protein to regulate the expression of parental genes and linear mRNAs. Next-generation RNA sequencing (RNA-seq) has recently shown that the expression of circRNAs is widespread in plants.
View Article and Find Full Text PDFArticle Synopsis
- MicroRNA (miRNA) is crucial for regulating plant development, and in hickory, it significantly influences flowering and production.
- The study identified 51 conserved miRNAs from 16 families and 195 novel miRNAs in the hickory genome, with some families showing gene expansion compared to other plants.
- Analysis revealed that many of these miRNAs are expressed in hickory flowers, suggesting they play vital roles in floral regulation, with functional similarities and differences compared to other plants like Arabidopsis and grape.
[Water mobility of diffusion MRI in prediction of response to chemoembolization in liver cancer].
Zhonghua Zhong Liu Za Zhi
April 2009
Objective: To investigate the value of pretreatment and posttreatment changes of apparent diffusion coefficients (ADCs) in predicting response to chemoembolization in liver cancer.
Methods: Patients with liver cancer were examined with diffusion-weighted MRI at two b values (0 and 500 s/mm(2)) before and after chemoemblization. Quantitative ADC maps were calculated using images under b values of 0 and 500 s/mm(2).