Publications by authors named "Zhi-chao Meng"
Article Synopsis
- Osteoarthritis (OA) is a leading cause of disability in older adults, and the study explores the role of PHF23, a new autophagy inhibitor, as a potential treatment target for OA.
- The research involved manipulating PHF23 levels in chondrocyte cell strains while evaluating the effects of OA inducers and lysosome inhibitors using various analytical methods.
- Key findings showed that knocking down PHF23 increased autophagy and mitophagy, reduced OA-associated proteins, and improved collagen expression, indicating that PHF23 could be a significant therapeutic focus for treating OA.
Background: Plant homeodomain finger protein 23 (PHF23) is a novel autophagy inhibitor gene that has been few studied with respect to orthopedics. This study was to investigate the expression of PHF23 in articular cartilage and synovial tissue, and analyze the relationship between PHF23 and chondrocyte autophagy in osteoarthritis (OA).
Methods: Immunohistochemical staining and western blot were applied to show the expression of PHF23 in cartilage of different outbridge grades and synovial tissue of patient with OA and healthy control.
Background: Researchers initially proposed the substitution of apoptotic chondrocytes in the superficial cartilage by injecting mesenchymal stem cells (MSCs) intraarticularly. This effect was termed as bio-resurfacing. Little evidence supporting the treatment of osteoarthritis (OA) by the delivery of a MSC suspension exists.
View Article and Find Full Text PDF[Effect of mitochondrial dysfunction of chondrocyte on cartilage degeneration].
Beijing Da Xue Xue Bao Yi Xue Ban
October 2014
Objective: To evaluate the effect of chondrocyte mitochondrial dysfunction on the development of cartilage degeneration.
Methods: In the study, 10 cartilage samples of the knee joint were collected during total knee arthroplasty surgery because of OA from April to October of 2012 in Peking University First Hospital. All the tissues were taken from transmission electron microscope (TEM) observation grouped by Outerbridge classification.
Aim: To investigate the expression of protein kinase CK2α (CK2α) in human thyroid disease and its relationship with thyroid cancer metastasis.
Materials And Methods: Using immunohistochemistry we measured the expression of CK2α in 76 benign and malignant human thyroid cancer tissues, including 10 pairs of papillary carcinoma tissues with or without lymph node cancerous metastasis and similarly 10 pairs of lymph nodes.
Results: The expression of CK2α was found to be higher in thyroid carcinoma cases (papillary carcinoma, follicular carcinoma, anaplastic carcinoma and medullary carcinoma) than in ones such as chronic lymphocytic thyroiditis, nodular goiter and adenoma.