[Effect of Gegen Qinlian Decoction on gut microbiota of irritable bowel syndrome with diarrhea rats].

This study aims to explore the effect of Gegen Qinlian Decoction on gut microbiota of irritable bowel syndrome with diarrhea(IBS-D) rats. A total of 36 male SD rats were randomly classified into the control group, model group, rifaximin group(150 mg·kg~(-1)), and high-dose(8.125 g·kg~(-1)), medium-dose(4.

[Association of cytochrome P450 gene MSP1 polymorphism and risk of preterm].

Objective: To investigate the association of cytochrome p450 gene (CYP1A1)MSP1 polymorphisms with preterm delivery.

Methods: Between July 1999 and June 2001, we conducted a case-control study using infant-parent triads including 247 families with full-term infants and 249 families with preterm delivery infants in Anqing, China. We extracted DNA from umbilical cord blood of the infants and vein blood of their parents,and performed PCR followed by restriction enzyme MspI digestion for genotyping the CYP1A1 gene MSP1 polymorphism.

Mother's and child's methylenetetrahydrofolate reductase C677T polymorphism is associated with preterm delivery and low birth weight.

Objective: To investigate the association of the C677T polymorphism of the 5,10-methyleneterahydrofolate reductase(MTHFR) gene with preterm delivery(PTD) and low birth weight (LBW).

Methods: A total of 250 normal gestational age families and 250 PTD families were enrolled in the study. Polymerase Chain Reaction (PCR) followed by restriction enzyme digestion were used for genotyping the polymorphism of MTHFR C677T.

Tumor necrosis factor-alpha gene G308A polymorphism is associated with the risk of preterm delivery.

Objective: To investigate the association between polymorphism in tumor necrosis factor-alpha(TNF-alpha)/G308A and preterm delivery (PTD). Between July 1999 and June 2001, we conducted a molecular epidemiological study on genetic determinants of PTD at Anqing Hospital, China.

Methods: In a case-control-parent triads study, we investigated a total of 133 nuclear families: 79 normal gestational age families and 54 PTD families.