Publications by authors named "Zhi-Zi Zhou"

Conversion from natural lands to cropland, primarily driven by agricultural expansion, could significantly alter soil microbiome worldwide; however, influences of forest-to-cropland conversion on microbial hierarchical interactions and ecosystem multifunctionality have not been fully understood. Here, we examined the effects of forest-to-cropland conversion on intratrophic and cross-trophic microbial interactions and soil ecosystem multifunctionality and further disclosed their underlying drivers at a national scale, using Illumina sequencing combined with high-throughput quantitative PCR techniques. The forest-to-cropland conversion significantly changed the structure of soil microbiome (including prokaryotic, fungal, and protistan communities) while it did not affect its alpha diversity.

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Household-related microbiome is closely related with human health. However, the knowledge about profiles of antibiotic resistance genes (ARGs) and virulence factor genes (VFGs) which are carried by microbes inside homes and their temporal dynamics are rather limited. Here we monitored the seasonal changes of bacterial community (especially pathogenic bacteria), ARGs, and VFGs in household dust samples during two years.

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Article Synopsis
  • Glycogen storage disease type Ib (GSD Ib) is a rare genetic condition that leads to severe health issues like low blood sugar and neutropenia due to mutations in the SLC37A4 gene, making traditional treatments ineffective for neutropenia.
  • Recent findings on the condition allowed for the use of the SGLT2 inhibitor empagliflozin, which has shown promise in improving neutrophil function and overall health in GSD Ib patients since its introduction in 2020.
  • A study of 35 pediatric GSD Ib patients revealed that empagliflozin treatment is effective and safe in managing the disease, although patients should be monitored for urinary infections and hypoglycemia as potential side effects.
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