Arc regulates brain damage and neuroinflammation via Sirt1 signaling following subarachnoid hemorrhage.

Aneurysmal subarachnoid hemorrhage (aSAH) accounts for only 5 % of all stroke cases, but carries a heavy burden of morbidity and mortality. Activity regulated cytoskeleton associated protein (Arc) is an immediate early gene (IEG)-coded postsynaptic protein that is involved in synaptic plasticity. Increasing evidence and our previous studies have shown that Arc might be involved in the pathological mechanism of various neurological diseases, such as traumatic brain injury (TBI).

Neuroprotective Effect of Ultrasound Triggered Astaxanthin Release Nanoparticles on Early Brain Injury After Subarachnoid Hemorrhage.

Subarachnoid hemorrhage (SAH) is a fatal disease. Within 72 h of SAH, the intracranial blood-brain barrier (BBB) is destroyed, and the nerve cells have responses such as autophagy, apoptosis, and oxidative stress. Antioxidation is an essential treatment of SAH.

Giant aneurysm of the bilateral vertebrobasilar junction treated by pipeline and coils: A case report and literature review.

Giant aneurysm of the posterior circulation is associated with a higher risk of rupture compared with that of the anterior circulation. Furthermore, surgical clipping and interventional embolization for giant aneurysm of the posterior circulation are more difficult and complex to perform. The present study reported on the case of a 26-year-old female who exhibited a giant spherical aneurysm of the vertebrobasilar junction (VBJ) with a maximum diameter of ~35 mm that caused cervical discomfort.

[Effect of modified cangfu daotan decoction in improving endometrial receptivity in infertility patients with polycystic ovarian syndrome].

Objective: To study the effect and potential mechanism of Modified Cangfu Daotan Decoction (MCDD) on endometrial receptivity in infertility patients with polycystic ovarian syndrome (PCOS).

Methods: Totally 298 women having normal ovulation who underwent artificial insemination were recruited as the control group, and they received no drug therapy. Another 355 infertility patients with PCOS who received ovarian stimulation therapy were recruited as the treatment group.

Involvement of reactive oxygen species and TATA box-binding protein-related factor 2 in testicular torsion/detorsion-induced injury.

Objective: To investigate whether overproduction of reactive oxygen species after testicular torsion-detorsion injures testicular spermatogenesis by regulating expression of TATA box-binding protein-related factor 2 (TRF2), which is an essential transcription factor for spermatogenesis. Testicular torsion-detorsion causes overproduction of reactive oxygen species, which contributes to testicular injury and regulates many genes whose expression affects cell cycle regulation, cell proliferation, and apoptosis.

Materials And Methods: A total of 60 adult male Sprague-Dawley rats were divided into 3 groups of 20 rats each.

Wave localization in two-dimensional porous phononic crystals with one-dimensional aperiodicity.

The localization properties of in-plane elastic waves propagating in two-dimensional porous phononic crystals with one-dimensional aperiodicity are initially analyzed by introducing the concept of the localization factor that is calculated by the plane-wave-based transfer-matrix method in this paper. The band structures characterized by using localization factors are calculated for different phononic crystals by altering matrix material properties and geometric structure parameters. Numerical results show that the effect of matrix material properties on wave localization can be ignored, while the effect of geometric structure parameters is obvious.

Protective effect of rutin on testicular ischemia-reperfusion injury.

Purpose: The pathophysiology of testicular torsion-detorsion is an ischemia-reperfusion injury caused by overgeneration of reactive oxygen species (ROS). This study aimed to investigate the effect of rutin, a well-known antioxidant, on testicular ischemia-reperfusion injury.

Methods: Sixty male Sprague-Dawley rats were randomly divided into 3 groups, each containing 20 rats.

Psoralea corylifolia protects against testicular torsion/detorsion-induced ischemia/reperfusion injury.

Ethnopharmacological Relevance: The pathophysiology of testicular torsion-detorsion is ischemia-reperfusion injury of the testis. In the course of testicular ischemia and reperfusion, overgeneration of reactive oxygen species is a major initiating component of the testicular spermatogenic injury. Reactive oxygen species regulate many genes whose expression affects cell-cycle regulation, cell proliferation, and apoptosis.

Curcumin attenuates ischemia-reperfusion injury in rat testis.

Objective: To evaluate the effect of curcumin, a potent antioxidant, on testicular ischemia-reperfusion injury caused by overgeneration of reactive oxygen species (ROS) after testicular torsion-detorsion.

Design: Controlled experimental study using rats.

Setting: Research laboratory.

Beneficial effect of taurine on testicular ischemia-reperfusion injury in rats.

Objectives: To evaluate the effect of taurine, a potent antioxidant, on testicular ischemia-reperfusion injury due to excess reactive oxygen species produced by neutrophils after testicular torsion-detorsion.

Methods: A total of 60 adult male Sprague-Dawley rats were randomly divided into three groups, each containing 20 rats. The control group underwent a sham operation of the left testis.

[Ultrastructure and function of mitochondria in idiopathic asthenospermia: study of 151 cases].

Objective: To explore the ultrastructure and function of mitochondria in idiopathic asthenospermia and the role thereof in the sperm activity.

Methods: Samples of sperm were collected from 151 idiopathic asthenospermia patients, 25% of whose sperms were classified as lower than grade A, were subdivided into 3 groups: Group A with the proportion of grade A sperms between 15% and 25%, Group B, with the proportion of grade A sperm between 15% and 5%, and Group C with the proportion of grade A sperm < 5%. Transmission electron microscopy was used to observe the ultrastructure of the mitochondria in the sperms.

Role of cAMP-responsive element modulator-tau (CREMtau) in ipsilateral testicular injury after unilateral testicular torsion-detorsion.

Objective: To investigate the role of cAMP-responsive element modulator-tau (CREMtau), an essential transcription factor for spermatogenesis, in ipsilateral testicular injury after unilateral testicular torsion-detorsion.

Design: Controlled experimental study using rats.

Setting: Research laboratory.

[Extract from Morindae officinalis against oxidative injury of function to human sperm membrane].

Objective: To study the intervention of Morindae officinalis extract in human sperm membrane, and to study the treatment of male infertility and asthenoospermia by M. officinalis.

Method: To select sperm with normal physiological function using the Percoll gradient centrifugation for the normal sperm model.

[Protection of extract from Cuscuta japonica on human sperm acrosome and ultrastructure].

Objective: To study the oxidation damage of active oxygen (ROS) to human sperm acrosome and ultrastructure, and study the function mechanism about Cuscuta japonica treating male's infertility and asthenoospermia.

Method: By using the Percoll gradient centrifugation, the sperm with normal physiological function were selected for the normal sperm model, and the sperm suspension were divided into the normal group, the model group, the positive control group (Vitamin C group), and the lugh, the median and the low dose gvoups of C. japonica.

Optical coherence tomography system with no high-precision scanning stage and stage controller.

Optical coherence tomography (OCT) is a novel technique for noninvasive imaging based on the use of a low-coherence interferometer. Conventionally, obtaining high-resolution images requires the use of high-precision sample and scanning stages and a stage controller for simultaneous measurement of the refractive index and the thickness of an optical sample. However, in this study a novel optical-fiber-type OCT system is developed that does not need both a high-precision scanning stage and a stage controller.