Publications by authors named "Zhi-Yue Gu"

Objective: To explore potential biomarkers indicating endometriosis (EM).

Materials And Methods: A proteomics method and combined quantitative transcriptomics were adopted to highlight markers in the EM. Venn analysis was used to integrate the ribonucleic acid sequencing (RNA-seq) and protein profiles.

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Article Synopsis
  • The study analyzed the differences in clinical features and outcomes between endometriosis (EM) patients with and without associated adenomyosis (AM) over a minimum follow-up period of 6 years post-surgery.
  • A total of 358 EM patients were divided into two groups: 142 with AM and 216 without; results indicated that those with AM were older, had longer surgery times, and higher mean AFS classification scores.
  • While both groups showed similar rates of disease relapse and successful live births, the AM group had a higher rate of failed pregnancies, highlighting differing reproductive outcomes between the two groups.
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Purpose: Here, we compared endometrioma recurrence rates in patients who have undergone a laparoscopic cystectomy and treated with a gonadotropin-releasing hormone agonist (GnRHa) alone or a GnRHa combined with a levonogestrel intrauterine system (LND-IUS).

Methods: We enrolled endometrioma patients who underwent laparoscopic cyst enucleation and divided them into two groups according to postoperative management: GnRHa alone and GnRHa in combination with LND-IUS. We compared preoperative history, perioperative parameters, postoperative endometrioma recurrence, and symptoms between these two groups.

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An ideal research model plays a vital role in studying the pathogenesis of a disease. At present, the most widely used endometrial disease models are cell lines and animal models. As a novel studying model, organoids have already been applied for the study of various diseases, such as disorders related to the liver, small intestine, colon, and pancreas, and have been extended to the endometrium.

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Endometriosis is a prevalent chronic disease that affects approximately 6% to 10% of reproductive-aged women. Although numerous researchers have endeavored to explore the etiology of endometriosis over a century, its etiology still remains an enigma. The exploration of pathophysiologic mechanism and novel therapy for endometriosis depends on ideal endometriotic models.

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