Publications by authors named "Zhi-Yu Zou"
Sirolimus in combination with low-dose extended-release tacrolimus in kidney transplant recipients.
Front Med (Lausanne)
December 2023
Introduction: Many challenges remain for long-term survival of renal allografts. Once-daily sirolimus (SRL) combined with low-dose extended-release tacrolimus (LER-TAC) may improve medication adherence and reduce the potential nephrotoxicity of calcineurin inhibitors (CNI) compared with standard immunosuppression regimens, thus potentially improving long-term graft survival.
Methods: This retrospective, observational, single-center, propensity score matching (PSM) study compared conversion to SRL combined with low-dose ER-TAC and mycophenolic acid (MPA) combined with standard-dose TAC in kidney transplant recipients.
Article Synopsis
- ABO-incompatible (ABO-i) kidney transplants are increasingly successful due to better immunosuppressive treatments, but they carry risks like complications and rejection.
- A case study describes a recipient with blood type O who received a kidney from a type B donor and initially succeeded after a desensitization process, but later experienced multiple rejection episodes due to a parvovirus B19 infection.
- The conclusion stresses that while desensitization and immunosuppressants are necessary, they can lead to serious infections that might trigger acute rejection and ultimately result in transplant failure.
Bike-sharing as a common public transportation has been booming in China in recent years. Previous studies showed that the surfaces of public transport can act as reservoirs of antimicrobial-resistant (AR) bacteria, but AR bacterial contamination of shared bikes has not been investigated. Otherwise, the AR-Enterobacteriaceae is considered as a global health threat for humans.
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