Publications by authors named "Zhi-Yu Chen"
Article Synopsis
- A 54-year-old male liver transplant patient initially treated with tacrolimus developed renal dysfunction, prompting a switch to sirolimus for immunosuppression.
- After starting sirolimus, the patient experienced worsening renal function and later developed rhabdomyolysis, linked to high sirolimus levels in serum and specific kidney damage seen in histopathology.
- Reducing the sirolimus dosage led to normalization of muscle enzyme levels and improved kidney function, emphasizing the need for careful monitoring of sirolimus concentrations to prevent such serious side effects.
Article Synopsis
- * A custom bioreactor was developed to create optimal culture conditions by using brief mechanical rotation to foster better aggregate sizes and improve cell viability, achieving a notable 144-fold increase in cell proliferation.
- * After 14 days, the NK-92MI cells retained their characteristics and displayed increased IFN-γ expression following IL-18 activation, enhancing their ability to target cancer cells effectively, indicating a valuable method for advancing immunocellular therapies.
Background: Birth defects constitute a significant public health issue worldwide, yet there is a lack of comprehensive population-based data for the Chinese population.
Methods: We analyzed data from the China National Population-based Birth Defects Surveillance System from 2007 to 2021, we calculated the prevalence rates of selected birth defects, stratified by maternal residence, geographic region, maternal age, and infant sex. The Joinpoint regression model was utilized to assess trends and annual percent changes in prevalence.
Article Synopsis
- This study focused on the prevalence and distribution of carcinoma along the liver margin (LM) in patients with resected perihilar cholangiocarcinoma (pCCA) and aimed to improve examination methods for LM.!
- The research analyzed 227 pCCA cases, revealing a significantly higher rate of R1 resection (indicating the presence of cancer at the margin) in the group assessed with whole-mount digital large sections compared to those assessed with smaller sections.!
- Findings indicate that positive LM is a critical factor for poor surgical outcomes and suggest that precise examination within a 20 mm radius of the proximal ductal margin is necessary, particularly for patients with a margin of less than 5 mm, to enhance diagnostic
Article Synopsis
- The study focuses on developing a preoperative prediction model for early recurrence in patients with perihilar cholangiocarcinoma (pCCA) after surgery, as this is a major cause of death in these patients.
- It involved 400 pCCA patients who underwent curative resection, with data divided into training and testing groups to identify significant predictive variables using LASSO regression alongside various machine learning models.
- Among the findings, five key factors were identified, and the random forest model showed the highest predictive accuracy with a notable difference in recurrence-free survival rates between high-risk and low-risk patients.
Objective: To investigate the clinical significance of using 3D printing guides in modified unilateral puncture percutaneous vertebroplasty (PVP) for the treatment of osteoporotic vertebral compression fractures (OVCF), and to explore a new method for preventing paravertebral vein leakage during PVP in conjunction with a previous study of the optimal puncture-side bone cement/vertebral volume ratio(PSBCV/VV%).
Methods: This retrospective study analyzed 99 patients who underwent unilateral puncture PVP between January 2023 and December 2023. Patients were divided into a guide plate group (46 patients) and a conventional group (53 patients).
Article Synopsis
- Achieving high cell transfection efficiency is crucial for medical applications, especially with natural killer (NK) cells, which pose challenges in gene delivery.
- This study introduces a modified non-viral gene transfection method using calcium phosphate/DNA nanoparticles (pDNA-CaP NPs) combined with low-voltage pulse electroporation to enhance gene introduction into NK-92 cells.
- The results showed that the pDNA-CaP NPs had a favorable size and DNA entrapment efficiency, leading to improved transfection efficiency and cell viability three days after treatment compared to traditional methods.
The objective of this study was to investigate the association between pre-operative body mass index (BMI) and surgical infection in perihilar cholangiocarcinoma (pCCA) patients treated with curative resection. Consecutive pCCA patients were enrolled from four tertiary hospitals between 2008 and 2022. According to pre-operative BMI, the patients were divided into three groups: low BMI (≤18.
View Article and Find Full Text PDFPostoperative tissue adhesion and poor tendon healing are major clinical problems associated with tendon surgery. To avoid postoperative adhesion and promote tendon healing, we developed and synthesized a membrane to wrap the surgical site after tendon suturing. The bilayer-structured porous membrane comprised an outer layer [1,4-butanediol diglycidyl ether cross-linked with carboxymethyl cellulose (CX)] and an inner layer [1,4-butanediol diglycidyl ether cross-linked with polysaccharides and carboxymethyl cellulose (CXB)].
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- The study explores how the CYP2D6 enzyme affects the metabolism of paroxetine, an antidepressant, to improve precision dosing in treatment, particularly among Chinese Han patients with depressive or anxiety disorders.
- Conducted over 8 weeks with 921 patients, it categorizes participants based on their CYP2D6 metabolizer status and evaluates treatment outcomes, showing significant differences in drug concentration and efficacy across various metabolizer types.
- The research highlights the need for tailored dosing strategies based on metabolic phenotypes, with specific recommendations for dosage adjustments in both East Asian and non-East Asian populations, factoring in sex and ethnicity as important variables.
Background: The prognostic value of carbohydrate antigen 19-9 (CA19-9) is known to be affected by elevated bilirubin levels in patients with gallbladder carcinoma (GBC). The clinical significance of changes in the ratio of CA19-9 levels to total bilirubin (TB) levels in patients with GBC after curative-intent resection remains unknown. The aim of this study was to determine the prognostic value of changes in preoperative and postoperative CA19-9/TB ratio in these patients.
View Article and Find Full Text PDFBackground: To construct an effective prognostic index to predict overall survival (OS) and triplet regimen efficacy for advanced gastric cancer (AGC) patients treated with platinum-based and fluorouracil-based chemotherapy.
Objectives: Between 2011 and 2021, 679 patients from two randomized phase III trials and one phase II trial were enrolled.
Designs: We collected 11 baseline clinicopathological and 14 hematological parameters to establish a prognostic index.
Article Synopsis
- The study investigated the prevalence, trends, and outcomes of congenital diaphragmatic hernia (CDH) in China from 2007 to 2019, revealing a total of 4,397 cases among over 24 million births.
- Results showed that CDH prevalence rates increased over time and varied significantly based on factors such as infant sex, maternal residence, age, and geographic region.
- The findings indicate higher risks of premature birth and perinatal death for infants with associated CDH compared to those with isolated CDH, emphasizing the need for more research in this area.
The adenosine 5'-triphosphate (ATP) regeneration system can significantly reduce the cost of many biocatalytic processes. Numerous studies have endeavored to utilize the ATP regeneration system based on PPK (PPK). However, the wild-type PPK enzyme possesses limitations such as low enzymatic activity, poor stability, and limited substrate tolerance, impeding its application in catalytic reactions.
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