An AIE probe for the fluorescence and colorimetric sensing of La.

In this work, a fluorescent probe with aggregation-induced emission effect was synthesized by grafting naphtho[2,3-]furan-1,3-dione and 2-hydrazinylbenzo[]thiazole. The probe could recognize La selectively and sensitively accompanied with an obvious fluorescence and color change from green to blue. Moreover, with the help of AIE properties, probe N achieved the detection of La in the solid state.

Development of an AIE-active fluorescent probe for the simultaneous detection of Al and viscosity and imaging in Alzheimer's disease model.

Alzheimer's disease is associated both with imbalances in Al production and changes in viscosity in cells. Their simultaneous measurement could therefore provide valuable insights into Alzheimer's disease pathology. Their simultaneous measurement would therefore be of great value in investigating the pathological mechanism of Alzheimer's disease.

Fanconi Anemia Complementary Group A (FANCA) Facilitates the Occurrence and Progression of Liver Hepatocellular Carcinoma.

Background: Liver hepatocellular carcinoma (LIHC) is a serious liver disease worldwide, and its pathogenesis is complicated.

Aims: This study investigated the potential role of FANCA in the advancement and prognosis of LIHC.

Methods: Public databases, quantitative reverse transcription polymerase chain reaction (qRT-PCR), western blot (WB) and immunohistochemistry (IHC) were employed to measure FANCA expression between tumor and normal samples.

A Facile Probe for Fluorescence Turn-on and Simultaneous Naked-Eyes Discrimination of HS and biothiols (Cys and GSH) and Its Application.

Hydrogen sulfide and biothiol molecules such as Cys and GSH acted important roles in many physiological processes. To simultaneously detect and distinguish them was quite necessary by a suitable fluorescent probe. A novel chemosensor 4-(4-(benzo[d]thiazol-2-yl)-2-methoxyphenoxy)-7-nitrobenzo[c][1,2,5]oxadiazole (BMNO) was designed to detect HS/Cys/GSH using the combination of nitrobenzofurazan (NBD) and benzothiazole fluorophores linked by a facile ether bond.

A dual-functional probe for sensing pH change and ratiometric detection of Cu.

A series of benzothiazole-based compounds were synthesized and characterized. Among them, probe Z showed significant dual-functional performance which was capable of sensing pH change and Cu. Probe Z displayed fluorescent turn-on under alkaline conditions due to deprotonation of the hydroxyl group along with the obviously color change from colorless to mint green.

A Benzothiazole-Based Fluorescent Probe for Ratiometric Detection of Al and Its Application in Water Samples and Cell Imaging.

An easily prepared benzothiazole-based probe (BHM) was prepared and characterized by general spectra, including H NMR, C NMR, HRMS, and single-crystal X-ray diffraction. Based on the synergistic mechanism of the inhabitation of intramolecular charge transfer (ICT), the BHM displayed high selectivity and sensitivity for Al in DMF/HO (, 1/1) through an obvious blue-shift in the fluorescent spectrum and significant color change detected by the naked eye, respectively. The binding ratio of BHM with Al was 1:1, as determined by the Job plot, and the binding details were investigated using FT-IR, H NMR titration, and ESI-MS analysis.

A novel dual-function probe for recognition of Zn and Al and its application in real samples.

A dual-function probe NAHH based on naphthalene was synthesized and characterized. Based on the combination effects derived from the inhabitation of photo-induced electron transfer (PET) and CN isomerization, probe NAHH achieved in the recognition of Zn and Al both through obvious fluorescence enhancement and color changes detected by naked eye, respectively. Probe NAHH showed high sensitivity with the limit of detection as low as 3.

A Naphthalimide-Based Fluorescence "Off-on-Off" Chemosensor for Relay Detection of Al and ClO.

A novel Al chemosensor was designed and synthesized on basis of the mechanism of ICT and CHEF. Upon addition of Al, the probe displayed a bright green fluorescence under UV radiation and visual color change from yellow to colorless. Spectrum titrations showed that could be recognized as a fluorescent turn-on probe with 10 M detection level.

A Highly Selective Fluorescence "Turn on" and Absorbance-Ratiometric Detection of Al in Totally HO and its Application in Test Paper.

A novel naphthalene based fluorescence probe NBDH was designed and synthesized. Probe NBDH exhibited highly selective and sensitive responses towards Al in HEPES-NaOH buffer solution (pH = 7.4).

A dual-function probe based on naphthalene for fluorescent turn-on recognition of Cu and colorimetric detection of Fe in neat HO.

A simple naphthalene derivative, 6-hydroxy-2-naphthohydrazide (NAH), was designed and synthesized through two facile steps reactions with the 6-hydroxy-2-naphthoic acid (NCA) as the starting material. In neat HO (10% 0.01 M HEPES buffer, v/v, pH = 7.

A naphthalene-quinoline based chemosensor for fluorescent "turn-on" and absorbance-ratiometric detection of Al and its application in cells imaging.

A new naphthalene-quinoline based chemosensor L was prepared and structurally characterized. L exhibited excellent selectivity and sensitivity to Al through distinct fluorescence enhancement (335-fold) and ratiometric detection in DMF/HO (v/v, 1/9) based on the combined mechanisms of ESIPT and CHEF. The recognizing behavior of L toward Al had been investigated in detail through Job's Plot, FT-IR, HNMR, and HRMS analysis.

A Highly Selective Naphthalimide-Based Chemosensor: "Naked-Eye" Colorimetric and Fluorescent Turn-On Recognition of Al and Its Application in Practical Samples, Test Paper and Logic Gate.

A novel naphthalimide-based colorimetric and fluorescent turn-on chemosensor for Al was synthesized and characterized with spectroscopic techniques. In MeOH solution, BPAM showed high selectivity and sensitivity to Al by a 60-fold fluorescence enhancement and blue-shift absorption with visible color changes attributed to the contribution of chelation enhanced fluorescence (CHEF) and inhibition of intramolecular charge transfer (ICT). A 1:1 BPAM-Al complex confirmed by job's plot and HRMS with a binding constant of 6.

A highly selective colorimetric and fluorescent turn-on chemosensor for Al(3+) based on naphthalimide derivative.

A new chemosensor L based on the naphthalimide moiety was synthesized and characterized. L exhibited the high selectivity and sensitivity for Al(3+) in CH3OH, along with colorimetric and fluorometric dual-signaling responses based on the joint contribution of the ICT and CHEF processes. A 1:1 stoichiometry for the L-Al(3+) complex was formed with an association constant of 7.

1-Dichloro-acetyl-8a-methyl-1,2,3,4,6,7,8,8a-octa-hydro-pyrrolo-[1,2-a]pyrimidin-6-one.

In the title compound, C(10)H(14)Cl(2)N(2)O(2), the five-membered ring adopts an envelope conformation (with the methylene C atom closest to the C-N bridge as the flap), while the conformation of the six-membered ring is close to a twist-boat. In the crystal, mol-ecules are linked by weak C-H⋯O hydrogen bonds, forming chains along the c-axis direction.

N'-[1-(4-Amino-phen-yl)ethyl]pyrazine-2-carbohydrazide.

The title compound, C(13)H(13)N(5)O, crystallizes with two mol-ecules in the asymmetric unit. The crystal structure is stabilized by intra-molecular N-H⋯N and N-H⋯O hydrogen bonds. The dihedral angles between the pyrazine ring and the 4-aminolphenyl ring are 2.