Publications by authors named "Zhi-Ye Huang"
Objectives: The 9th edition of tumour-node-metastasis (TNM) staging for lung cancer was announced by Prof Hisao Asamura at the 2023 World Conference on Lung Cancer in Singapore. The purpose of this study was to externally validate and compare the latest staging of lung cancer.
Methods: We collected 19 193 patients with stage IA-IIIA non-small cell lung cancer (NSCLC) who underwent lobectomy from the Surveillance, Epidemiology and End Results database.
Article Synopsis
- This study explored the prevalence and prognostic impact of BRAF mutations in early-stage lung adenocarcinoma (LUAD) patients, revealing that only 5.6% had these mutations.
- The researchers analyzed data from over 2,000 patients and found that BRAF mutations did not significantly affect recurrence-free survival (RFS) compared to patients without these mutations.
- The findings suggest that BRAF mutation status may not serve as a reliable prognostic indicator for stage I LUAD patients, highlighting the need for further research to confirm these results.
Background: Colorectal cancer (CRC) presents a significant global health burden, characterized by a heterogeneous molecular landscape and various genetic and epigenetic alterations. Programmed cell death (PCD) plays a critical role in CRC, offering potential targets for therapy by regulating cell elimination processes that can suppress tumor growth or trigger cancer cell resistance. Understanding the complex interplay between PCD mechanisms and CRC pathogenesis is crucial.
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