Accelerated interfacial proton transfer for promoting electrocatalytic activity.

Interfacial pH is critical to electrocatalytic reactions involving proton-coupled electron transfer (PCET) processes, and maintaining an optimal interfacial pH at the electrochemical interface is required to achieve high activity. However, the interfacial pH varies inevitably during the electrochemical reaction owing to slow proton transfer at the interfacial layer, even in buffer solutions. It is therefore necessary to find an effective and general way to promote proton transfer for regulating the interfacial pH.

In Situ Imaging of Live-Cell Extracellular pH during Cell Apoptosis with Surface-Enhanced Raman Spectroscopy.

Extracellular pH (pHe) is an important regulating factor that determines many cellular processes, including proliferation, differentiation, and apoptosis. In our previous work, we developed 4-MPy (4-mercaptopyridine) modified Au nanoparticles as intracellular pH sensors based on surface-enhanced Raman spectroscopy (SERS). We herein modified a Au-nanoparticle-assembled solid SERS substrate with 4-MPy molecules for in situ pHe sensing during apoptosis.