Publications by authors named "Zhi-Wu Tong"
Article Synopsis
- - The study focuses on a newly discovered hybrid polyketide called spirocycline A, generated from a gene cluster that combines modular type I and type II polyketide synthases (PKSs) alongside KAS III enzymes, which is a rare occurrence in bacterial aromatic polyketides.
- - Spirocycline A's unique structure includes a distinct starter unit, four spirocycles, and a dimer formation, differentiating it from existing aromatic polyketides.
- - The biosynthesis involves a collaborative effort where the type I PKS synthesizes the starter unit, which is then processed by KAS III and type II PKS to create the aromatic backbone, followed by further modifications by specific redox
Parkinson's disease (PD) is the second most common neurodegenerative disease, and its prevalence is increasing. Currently, no effective therapies for PD exist. Marine-derived natural compounds are considered important resources for the discovery of new drugs due to their distinctive structures and diverse activities.
View Article and Find Full Text PDFThe solid-state cultivation of sp. H-JQSF isolated from produces acautalides A-C (-) as skeletally unprecedented Diels-Alder adducts of a 14-membered macrodiolide to an octadeca-9,11,13-trienoic acid. The acautalide structures, along with the intramolecular transesterifications of 1-acylglycerols, were elucidated by mass spectrometry, nuclear magnetic resonance, chemical transformation, and single-crystal X-ray diffraction.
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