Publications by authors named "Zhi-Tao Yang"
Rationale And Objective: To investigate the MR characteristics of phlegmonous stage and abscess stage primary spinal epidural abscess.
Materials And Methods: This study retrospectively analyzed the clinical and imaging characteristics of 27 cases of pathologically confirmed primary spinal epidural abscess. Predisposing conditions of all patients were collected.
Article Synopsis
- The study looked at using special computer techniques on CT scans to help doctors figure out if patients have pheochromocytoma (PHEO) or lipid-poor adrenal adenoma (LPA).
- Researchers used data from 332 patients and made different models to see which one worked best at predicting these conditions based on CT scan images.
- The results showed that the models using CT scans worked really well, with scores close to perfect, and models using enhanced scans were slightly better, but not by much.
Objective: To investigate the mid-term effect and complications of arthroscopic popliteal tendon suture in the treatment of lateral meniscus injury.
Methods: From January 2016 to December 2020, the data of 57 patients with lateral meniscus popliteal tendon injury treated by arthroscopic popliteal tendon suture fixation were retrospectively analyzed, including 35 males and 22 females, aged from 18 to 47 years old with an average of (32.9±7.
Acute kidney injury (AKI) is a common serious complication in sepsis patients with a high mortality rate. This study aimed to develop and validate a predictive model for sepsis associated acute kidney injury (SA-AKI). In our study, we retrospectively constructed a development cohort comprising 733 septic patients admitted to eight Grade-A tertiary hospitals in Shanghai from January 2021 to October 2022.
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- The objective of the study was to evaluate how obesity impacts the outcomes after rotator cuff repair surgery.
- Researchers conducted a systematic review of 13 studies encompassing over 85,000 patients, comparing outcomes between obese and non-obese individuals.
- Findings revealed that obesity is linked to higher rates of retear, reoperation, complications, and poorer functional scores and pain levels post-surgery, but no significant differences were found in operative time or shoulder rotation angle.
Article Synopsis
- The shoulder joint is the most flexible joint in our body, allowing for a lot of different movements.
- To study how the shoulder moves, scientists use a method called optical motion capture, which is safe and doesn't involve radiation.
- This review explains how optical motion capture works, how to make the data better by reducing errors, and how it can help us understand shoulder problems better.
Superior labrum anterior posterior (SLAP) injury is a major challenge for orthopedic surgeons, due to the poor healing ability of the injured labrum. Although arthroscopic surgery is the gold standard for the treatment of SLAP injury, there are still disputes about the adaptation of different surgical techniques, the choice of anchors during operation, knotted or knotless anchors, and fixation methods. The authors believe that arthroscopic repair of SLAP lesions is effective for young patients with intact glenoid labrum(<35 years old) or with extensive activity, where single and knotless anchor is preferred.
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- The surgical treatment of massive rotator cuff tears poses challenges due to factors like tendon retraction and fatty infiltration, leading to ongoing research for better repair methods.
- Shoulder arthroscopic surgery is now considered the gold standard for these tears, though the effectiveness of different surgical techniques remains debated.
- Recommendations for treatment vary based on patient factors: elderly patients might benefit from debridement, while younger, more active patients may need complete repairs, tendon transfers, or superior capsular reconstruction for optimal outcomes.
Purpose: Infection with carbapenem-resistant (CRKP) is a great challenge. Central nervous system (CNS) infection caused by CRKP is rarely reported, and effective treatment is limited. Thus, this study aimed to assess intrathecal (IT) or intraventricular (IVT) injection of tigecycline for clearing infection with CRKP in CNS.
View Article and Find Full Text PDFObjective: To investigate the method and clinical effects of the treatment of recurrent shoulder dislocation with severe glenoid injury by arthroscopic subscapularis augmentation.
Methods: From March 2019 to August 2020, 16 patients with recurrent dislocation of shoulder with severe glenoid injury underwent arthroscopic subscapularis augmentation, including 10 males and 6 females, aged from 18 to 50 years old with an average of (29.06±10.
Background: Anastomotic leakage (AL) is one of the most serious postoperative complications. This study aimed to investigate the predictive value of preoperative body composition for AL in patients with colorectal cancer (CRC).
Methods: We first reviewed data from 3,681 patients who underwent radical CRC resection 2013-2021 in our hospital, and 60 patients were diagnosed with AL after surgery.
Article Synopsis
- - A novel risk score was developed to better predict in-hospital mortality for adult sepsis patients, addressing limitations of existing scoring systems.
- - The study analyzed data from 1,335 adult sepsis patients, separating them into modeling and validation groups, and identified key risk factors such as age, central vein catheterization, and vital signs.
- - This new scoring system outperformed existing ones like APACHE II and MEWS, categorizing patients into four risk levels with corresponding mortality rates ranging from 9.8% to 83.5%.
Background: Ferroptosis is a nonapoptotic form of programmed cell death, which may be related to the occurrence and development of sepsis-induced acute respiratory distress syndrome (ARDS)/acute lung injury (ALI). Mucin 1 (MUC1) is a kind of macromolecule transmembrane glycoprotein. Previous studies have shown that MUC1 could relieve ALI in sepsis and predict whether sepsis patients would develop into ARDS.
View Article and Find Full Text PDFObjective: To compare difference in clnical efficacy between arthroscopic double posterior internal approach and incisional surgery for acute simple posterior cruciate ligament tibial avulsion fractures.
Methods: Totally 52 patients with acute simple posterior cruciate ligament tibial avulsion fractures treated from June 2016 to June 2020 were retrospectively analyzed and divided into two groups according to different surgical protocols, 27 patients in arthroscopic group were treated with arthroscopic double posterior internal approach, including 16 males and 11 females, aged from 19 to 52 years old, with an average age of (34.9±9.
Objective: To investigate the early efficacy of arthroscopic autologous osteochondral grafting in the treatment of recurrent anterior shoulder dislocation.
Methods: From January 2019 to January 2021, 17 patients with recurrent anterior dislocation of shoulder who underwent arthroscopic autologous osteochondral grafting were selected, including 12 males and 5 females, ranging in age from 17 to 55 years old, with a mean of (32.88±12.
This study aimed to investigate whether free fatty acids (FFAs) could induce the release of neutrophil extracellular traps (NETs), as well as the mechanism of FFAs-induced NETs in acute lung injury (ALI). FFAs were used to induce NETs production. The reactive oxygen species (ROS) production was detected after FFA and NADPH oxidase inhibitor treatments.
View Article and Find Full Text PDFGiant cell tumors of the mobile spine with invasion of adjacent vertebrae: an unusual imaging finding.
BMC Musculoskelet Disord
August 2021
Background: Giant cell tumors of the mobile spine invasion of the adjacent vertebrae are an ignored imaging finding.
Methods: Nine patients with giant cell tumors of the mobile spine with invasion of the adjacent vertebrae confirmed by pathology were enrolled. Eight patients had pure giant cell tumors (GCTs), while one patient also had an aneurysmal bone cyst.
Objectives: Accurate preoperative differentiation between squamous cell carcinoma (SCC) and non-Hodgkin's lymphoma (NHL) in the palatine tonsil is crucial because of their different treatment. This study aimed to construct and validate a contrast-enhanced CT (CECT)-based radiomics nomogram for preoperative differentiation of SCC and NHL in the palatine tonsil.
Methods: This study enrolled 135 patients with a pathological diagnosis of SCC or NHL from two clinical centers, who were divided into training (n = 94; SCC = 50, NHL = 44) and external validation sets (n = 41; SCC = 22, NHL = 19).
Article Synopsis
- The study examines the rising incidence of Candida bloodstream infections (BSIs) over 11 years at a large hospital in Shanghai and analyzes risk factors for mortality and the effects of antifungal treatments.
- Out of 370 patients with 393 BSI episodes, a 28.5% mortality rate was recorded, which was notably lower for those who received antifungal therapy compared to those who did not.
- Notable independent risk factors for 28-day mortality included age, chronic renal failure, mechanical ventilation, and severe neutropenia, highlighting the importance of timely antifungal intervention.
Article Synopsis
- * Survivors generally maintained a negative fluid balance starting from the second day, while non-survivors had a positive fluid balance over the entire week, indicating the importance of fluid management.
- * The study found that both mean daily fluid balance and the Acute Physiologic and Chronic Health Evaluation II score are independent prognostic factors for patients with sepsis or septic shock, suggesting that careful fluid management is crucial for better outcomes.
Background: Using standard vancomycin dosage in critically ill patients might lead to therapy failure and worse patient outcomes, augmented renal clearance (ARC) may be the leading risk factor. In this study, we comprehensively investigated the pharmacokinetics-pharmacodynamics (PK-PD) of vancomycin in critically ill patients with ARC, hoping to explore the precise and accurate dose adjustment method for vancomycin.
Methods: All critically ill patients tested for steady-state trough vancomycin serum concentrations during the recent 6 years in a tertiary level hospital were collected retrospectively and divided into ARC and non-ARC groups, respectively, according to creatinine clearance (CLcr).
Sepsis remains a major global concern and is associated with high mortality and morbidity despite improvements in its management. Markers currently in use have shortcomings such as a lack of specificity and failures in the early detection of sepsis. In this study, we aimed to identify key genes involved in the molecular mechanisms of sepsis and search for potential new biomarkers and treatment targets for sepsis using bioinformatics analyses.
View Article and Find Full Text PDFBackground: Fluid management is crucial to acute respiratory distress syndrome (ARDS) secondary to sepsis. However, choices of fluid resuscitation strategies and fluid input volumes remain a thorny problem. Our study aimed to elucidate the relationship between fluid balance and prognosis of ARDS patients secondary to sepsis.
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- Oxidative stress significantly contributes to the severity of acute pancreatitis, and this study investigates the effects of high-dose intravenous Vitamin C as an antioxidant treatment in rats with induced pancreatic injury.* -
- The research showed that Vitamin C reduces cell apoptosis, lowers oxidative stress markers, and improves survival rates in rats with acute pancreatitis, primarily by activating the NRF2/NQO1/HO-1 signaling pathway.* -
- Vitamin C treatment also decreased the levels of inflammatory markers and harmful enzymes in plasma, indicating its potential therapeutic benefits in managing severe acute pancreatitis.*
Objective: We aimed to investigate whether inhibition of MUC1 would aggravate sepsis-induced ALI, and explore the predictive value of plasma MUC1 for sepsis patients with or without ARDS.
Materials And Methods: MUC1 siRNA pre-treatment was used to knockdown MUC1 expression in vitro. GO203 was used to inhibit the homodimerization of MUC1-C in vivo.