Publications by authors named "Zhi-Tao Lu"
[The role and mechanism of autophagy in lipopolysaccharide-induced inflammatory response of A549 cells].
Zhongguo Dang Dai Er Ke Za Zhi
October 2022
Article Synopsis
- - The study aimed to find out how autophagy, a process that helps the body clean up damaged cells, affects inflammation in A549 cells when exposed to LPS, a substance that can cause inflammation.
- - Researchers tested different conditions, like using inhibitors and stimulators of autophagy, to see how these affected the levels of inflammatory and autophagy-related proteins in the cells.
- - The results showed that when LPS was added, some proteins related to inflammation increased, while others related to autophagy decreased, depending on whether the cells' autophagy was increased or decreased.
Article Synopsis
- Human cytomegalovirus (HCMV) is the leading viral cause of birth defects and mental disability in newborns, with its UL141 glycoprotein helping infected cells evade immune response.
- The study explored how HCMV UL141 interacts with the human protein CELF5, finding that UL141 binds directly to CELF5 and co-locates in cell cytoplasm.
- While CELF5 overexpression increased HCMV viral copy number and production, reducing CELF5 levels had no effect, suggesting CELF5 may play a role in regulating viral DNA synthesis, potentially contributing to neurological issues.
Infection with certain types of human papillomaviruses (HPVs) is a risk factor for the development of cervical cancer. HPV type 58 (HPV 58) is prevalent among Chinese women. The intratype sequence variants differ in oncogenic potential and their prevalences vary across geographic regions.
View Article and Find Full Text PDF