Survival-associated alternative splicing events interact with the immune microenvironment in stomach adenocarcinoma.

Background: Alternative splicing (AS) increases the diversity of mRNA during transcription; it might play a role in alteration of the immune microenvironment, which could influence the development of immunotherapeutic strategies against cancer.

Aim: To obtain the transcriptomic and clinical features and AS events in stomach adenocarcinoma (STAD) from the database. The overall survival data associated with AS events were used to construct a signature prognostic model for STAD.

CircRNAs: a new target for the diagnosis and treatment of digestive system neoplasms.

A circRNA is a type of endogenous noncoding RNA that consists of a closed circular RNA molecule formed by reverse splicing; these RNAs are widely distributed in a variety of biological cells. In contrast to linear RNAs, circRNAs have no 5' cap or 3' poly(A) tail. They have a stable structure, a high degree of conservation, and high stability, and they are richly and specifically expressed in certain tissues and developmental stages.

Ferroptosis: past, present and future.

Ferroptosis is a new type of cell death that was discovered in recent years and is usually accompanied by a large amount of iron accumulation and lipid peroxidation during the cell death process; the occurrence of ferroptosis is iron-dependent. Ferroptosis-inducing factors can directly or indirectly affect glutathione peroxidase through different pathways, resulting in a decrease in antioxidant capacity and accumulation of lipid reactive oxygen species (ROS) in cells, ultimately leading to oxidative cell death. Recent studies have shown that ferroptosis is closely related to the pathophysiological processes of many diseases, such as tumors, nervous system diseases, ischemia-reperfusion injury, kidney injury, and blood diseases.

[The time for beginning of enteral nutrition in traumatic shock].

Objective: To explore the value of monitoring CO(2) partial pressure of gastric mucosa (PiCO(2)) in patients with traumatic shock under enteral nutrition (EN) support.

Methods: Ninety-six patients who were clinically diagnosed as having traumatic shock were randomly divided into two groups: the test group and the control group. In the test group, EN was given after tissue oxygenation, indicated by the value of PiCO(2), approached normal and the clinical symptoms ameliorated.