Publications by authors named "Zhi-Sheng Ye"
Large sample theory of semiparametric models based on maximum likelihood estimation (MLE) with shape constraint on the nonparametric component is well studied. Relatively less attention has been paid to the computational aspect of semiparametric MLE. The computation of semiparametric MLE based on existing approaches such as the expectation-maximization (EM) algorithm can be computationally prohibitive when the missing rate is high.
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- The study examines how intestinal microbial communities change in patients with end-stage liver disease after they receive a liver transplant (LT).
- It reveals significant differences in gut microbiota between patients before and after LT, as well as between these patients and healthy controls, highlighting the impact of liver disease on gut health.
- Additionally, the research identifies specific microbial species whose abundance changes post-transplant and notes shifts in functional modules, indicating that LT profoundly influences gut microbiome composition and function.