Publications by authors named "Zhi-Shang Wang"
Article Synopsis
- * The study examined the effects of icariin, a potential protective agent, against ethanol-induced atrial damage, finding that icariin reversed harmful changes while its benefits were lost when combined with Erastin, a ferroptosis activator.
- * Mechanistically, icariin improved atrial health by activating SIRT1 signaling, reducing oxidative stress and other indicators of ferroptosis, suggesting potential for icariin as a treatment for AF linked to ethanol exposure.
Polydatin has attracted much attention as a potential cardioprotective agent against ischemic heart disease and diabetic cardiomyopathy. However, the effect and mechanism of polydatin supplementation on alcoholic cardiomyopathy (ACM) are still unknown. This study aimed to determine the therapeutic effect of polydatin against ACM and to explore the molecular mechanisms with a focus on SIRT6-AMP-activated protein kinase (AMPK) signaling and mitochondrial function.
View Article and Find Full Text PDFMitochondrial reactive oxygen species (ROS) damage and atrial remodeling serve as the crucial substrates for the genesis of atrial fibrillation (AF). Branched-chain amino acids (BCAAs) catabolic defect plays critical roles in multiple cardiovascular diseases. However, the alteration of atrial BCAA catabolism and its role in AF remain largely unknown.
View Article and Find Full Text PDFArticle Synopsis
- Melatonin shows promise in reducing diabetic cardiomyopathy (DCM) by improving mitochondrial quality control, though the exact mechanisms need further exploration.
- In a study using diabetic rats, prolonged melatonin treatment increased SIRT6 and AMPK-PGC-1α-AKT signaling, leading to reduced mitochondrial damage and better heart function.
- Blocking SIRT6 or melatonin receptors negated the benefits of melatonin, indicating that the SIRT6-AMPK-PGC-1α-AKT pathway is crucial for its cardioprotective effects in the context of diabetes.