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Publications by authors named "Zhi-Ru Zou"

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Zinc remodels mitochondrial network through SIRT3/Mfn2-dependent mitochondrial transfer in ameliorating spinal cord injury.
Hui Guo Li-Qing Chen Zhi-Ru Zou Shuai Cheng Yu Hu

Eur J Pharmacol

April 2024

Article Synopsis
  • Spinal cord injury (SCI) leads to various dysfunctions and is heavily influenced by mitochondrial problems stemming from the initial trauma.
  • Zinc has beneficial effects on neurons by promoting neurogenesis and regulating mitochondrial function, which helps in rescuing damaged mitochondria after SCI.
  • The study shows that zinc facilitates mitochondrial transfer from microglia to neurons via SIRT3 regulation of Mitofusin 2, improving neuronal survival and motor function recovery in SCI mice.
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Ginsenoside Rb1 improves energy metabolism after spinal cord injury.
Shan Wen Zhi-Ru Zou Shuai Cheng Hui Guo Heng-Shuo Hu

Neural Regen Res

June 2023

Mitochondrial damage caused by oxidative stress and energy deficiency induced by focal ischemia and hypoxia are important factors that aggravate diseases. Studies have shown that ginsenoside Rb1 has neurotrophic and neuroprotective effects. However, whether it influences energy metabolism after spinal cord injury remains unclear.

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Synopsis of recent research by authors named "Zhi-Ru Zou"

  • - Zhi-Ru Zou's recent research focuses on the role of mitochondrial function and metabolic pathways in alleviating the effects of spinal cord injury (SCI), highlighting potential therapeutic interventions.
  • - In the study titled "Zinc remodels mitochondrial network through SIRT3/Mfn2-dependent mitochondrial transfer in ameliorating spinal cord injury," the research demonstrates that zinc can enhance mitochondrial health and support neurogenesis and immune response following SCI.
  • - Another study, "Ginsenoside Rb1 improves energy metabolism after spinal cord injury," explores the neuroprotective properties of ginsenoside Rb1, suggesting its ability to mitigate oxidative stress and energy deficiencies post-injury, thereby improving recovery outcomes.

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