Publications by authors named "Zhi-Quan Fan"
Article Synopsis
- The research investigates the origins, diversification, and demographic history of the O1a-M119 lineage over the past 10,000 years, focusing on its impact on East and Southeast Asian populations, particularly the Han, Tai-Kadai, and Austronesian groups.
- The study utilized Y-chromosome sequences, including both new and previously collected data, to create a revised phylogenetic tree and analyze the geographic distribution of O1a-M119 sub-lineages among Chinese males.
- Findings reveal the continuous expansion of O1a-M119 and suggest a shared ancestry among the studied populations during the Neolithic Age, while highlighting the complexity of paternal genetic divergence across regions.
Article Synopsis
- This study investigates the origins and differentiation of Austronesian populations and their languages, focusing on the paternal lineage of Malays in Southeast Asia and their separation from related Asian groups like the Daic and Austro-Asiatic populations.
- Researchers analyzed Y-chromosome sequences from 50 Malays and 200 other related individuals, discovering six major paternal lineages with a similar expansion timeline dating back 5,000 to 6,000 years ago.
- The findings support theories by prior researchers about the common ancestry of Austronesians, showing that the emerging paternal lineages likely coincide with the early differentiation of modern Austronesian populations.
Segregation distortion (SD) is defined as abnormal segregation ratio of hybrid offsprings at some genetic loci deviating from the Mendelian ratio. SD results from the incompatibility among genes from different parents, which could be due to loss-of-function or gain-of-function gene interactions. The mechanism for loss-of-function SD is relatively simple: defective gene combination leads to loss of the original function and eventual cell death.
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