Publications by authors named "Zhi-Qiang An"
Recent progress in antibody-based therapeutics for triple-negative breast cancer.
Expert Opin Drug Deliv
July 2022
Article Synopsis
- - Triple-negative breast cancer (TNBC) is an aggressive form of breast cancer that doesn’t express key receptors (ER, PR, HER2), leading to poor outcomes and limited treatment options.
- - Recent developments in immunotherapy, such as antibody-based drugs and CAR-T cells, show potential for more effective treatment against TNBC by targeting its unique immune characteristics.
- - Experts believe that novel immunotherapies could significantly improve the management of TNBC, addressing the ongoing challenges of treating this difficult cancer type.
In their natural habitat, bacteria are consumed by bacterivorous nematodes; however, they are not simply passive preys. Here we report a defensive mechanism used by certain bacteria to mobilize nematode-trapping fungi to kill nematodes. These bacteria release urea, which triggers a lifestyle switch in the fungus Arthrobotrys oligospora from saprophytic to nematode-predatory form; this predacious form is characterized by formation of specialized cellular structures or 'traps'.
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