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Publications by authors named "Zhi-Ming Xing"

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G-quadruplexes on chromosomal DNA negatively regulates topoisomerase 1 activity.
Hui-Ting Liang Jiang-Yu Yan Hao-Jun Yao Xue-Nan Zhang Zhi-Ming Xing

Nucleic Acids Res

March 2024

Human DNA topoisomerase 1 (Top1) is a crucial enzyme responsible for alleviating torsional stress on DNA during transcription and replication, thereby maintaining genome stability. Previous researches had found that non-working Top1 interacted extensively with chromosomal DNA in human cells. However, the reason for its retention on chromosomal DNA remained unclear.

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Synopsis of recent research by authors named "Zhi-Ming Xing"

  • - Zhi-Ming Xing's recent research focuses on the interaction between G-quadruplexes in chromosomal DNA and the activity of human DNA topoisomerase 1 (Top1), highlighting the role of these structures in genomic stability.
  • - His study suggests that G-quadruplexes negatively regulate the activity of Top1, which is vital for relieving torsional stress during DNA transcription and replication.
  • - The findings contribute to understanding how alterations in Top1 interaction with chromosomal DNA may impact genome stability, potentially informing future cancer research and therapeutic strategies.

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