Electrochemical-Induced C-N Bond Formation: A New Method to Synthesis ()-Quinazolinone Oximes Using Primary Amines and Quinazolin-4(3)-one.

A novel and highly selective electrochemical method for the synthesis of diverse quinazolinone oximes via direct electrooxidation of primary amines/C(sp)-H functionalization of oximes has been developed. The reaction is conducted in an undivided cell under constant current conditions and is oxidant-free, open-air, and eco-friendly. Notably, the protocol shows good functional group tolerance, providing versatile quinazolinone oximes in good yields.

Selective and effective separation of five condensed arenes from a high-temperature coal tar by extraction combined with high pressure preparative chromatography.

An environmentally benign and cost-effective method was designed for isolating and purifying condensed arenes from acetone-extractable portion (AEP) of a high-temperature coal tar through a high pressure preparative chromatograph (HPPC) with different packings, including silica gel, octadecyl silane, octyl bonded silica gel, and diol bonded silica gel. In total, 196 compounds were detected with a gas chromatograph/mass spectrometer from AEP and its eluates. From the eluates, naphthalene, anthracene, phenanthrene, fluoranthene, and pyrene were successfully isolated and purified, and their structures were confirmed by their H and C nuclear magnetic resonance spectra in addition to their mass spectra.

Optimization of Ultrasonic-Microwave Assisted Extraction and Hepatoprotective Activities of Polysaccharides from .

Ultrasonic-microwave assisted extraction (UMAE) of polysaccharides was optimized by response surface methodology. Hepatoprotective effects of a purified polysaccharide (TOP-2) were evaluated by alcohol-induced liver injury model mice. The optimal UMAE parameters were indicated as below: ratio of water to raw material 28 mL/g, microwave power 114 W, extraction time 11 min.

A novel galactose-PEG-conjugated biodegradable copolymer is an efficient gene delivery vector for immunotherapy of hepatocellular carcinoma.

Successful immunogene therapy depends not only on the therapeutic gene but also on the gene delivery vector. In this study, we synthesized a novel copolymer consisting of low-molecular-weight polyethylenimine (PEI) cross-linked by myo-inositol (INO) and conjugated with a galactose-grafted PEG chain, named LA-PegPI. We characterized the chemical structure and molecular weight of the copolymer and particle properties of LA-PegPI/pDNA.

Rapid analysis of carboxylic acids and esters with a direct analysis in real time ion source.

Rationale: Coal oxidation produces carboxylic acids (CAs), including aliphatic acids, benzoic acids, and benzenepolycarboxylic acids, which are important fine chemicals which could be used to understand the structural features of coals. However, detecting CAs usually presents great challenges due to extremely troublesome pretreatments. Therefore, it is essential to develop an analytical method for the rapid detection of CAs from coal oxidation.

Ameliorative effect of Trametes orientalis polysaccharide against immunosuppression and oxidative stress in cyclophosphamide-treated mice.

The present study evaluated the ameliorative effects of Trametes orientalis polysaccharide (TOP-2) against cyclophosphamide (CP) induced toxicity in mice. Intraperitoneal administration of TOP-2 not only effectively increased the thymus, spleen, heart, liver, and kidney indices, but also significantly enhanced the phagocytic activities of macrophages and splenocyte proliferation, dose-dependently. The lowered nitric oxide level of macrophages after CP treatment was elevated by TOP-2 administration.

Removal of hexavalent chromium from aqueous solution by calcined Zn/Al-LDHs.

In this study, Zn/Al-layered double hydroxides (Zn/Al-LDHs) were synthesized by a co-precipitation method and characterized with X-ray diffraction, Fourier transform infrared spectroscopy, and scanning electron microscopy. Then the hexavalent chromium Cr(VI) adsorption experiments on calcined Zn/Al-LDHs were carried out to analyze the effects of pH, temperature, adsorption time, initial Cr(VI) concentration and adsorbent dosage on the removal of Cr(VI) from aqueous solutions. The maximum adsorption capacity for Cr(VI) on calcined Zn/Al-LDHs under optimal conditions was found to be over 120 mg/g.

Application of mass spectrometry in the characterization of chemicals in coal-derived liquids.

Coal-derived liquids (CDLs) are primarily generated from pyrolysis, carbonization, gasification, direct liquefaction, low-temperature extraction, thermal dissolution, and mild oxidation. CDLs are important feedstocks for producing value-added chemicals and clean liquid fuels as well as high performance carbon materials. Accordingly, the compositional characterization of chemicals in CDLs at the molecular level with advanced analytical techniques is significant for the efficient utilization of CDLs.

Bottom-up synthesis of nitrogen-doped graphene sheets for ultrafast lithium storage.

A facile bottom-up strategy was developed to fabricate nitrogen-doped graphene sheets (NGSs) from glucose using a sacrificial template synthesis method. Three main types of nitrogen dopants (pyridinic, pyrrolic and graphitic nitrogens) were introduced into the graphene lattice, and an inimitable microporous structure of NGS with a high specific surface area of 504 m(2) g(-1) was obtained. Particularly, with hybrid features of lithium ion batteries and Faradic capacitors at a low rate and features of Faradic capacitors at a high rate, the NGS presents a superior lithium storage performance.

Synergic effect of methanol and water on pine liquefaction.

Pine liquefaction (PL) and re-liquefaction of its liquefaction residues in sub- and supercritical methanol, water or methanol/water mixed solvents (MWMSs) was investigated. The results show that isometric MWMS has the highest synergic effect on PL. Moreover, the total yield of bio-oil (BO) and conversion from pine and its residue both liquefied in the MWMS were obvious higher than those from PL in methanol (water) and re-liquefaction of its residue in water (methanol), suggesting that the interaction between the two solvents is responsible for synergic effect.

Investigation on infrared laser desorption of solid matrix using scanning electron microscope and fast photography.

Infrared light from a pulsed optical parametric oscillator laser system was used to irradiate succinic acid (SA), a usual solid matrix used in matrix-assisted laser desorption ionization, under vacuum. Ablated SA particles were trapped using a silica plate mounted 3.0 mm above and parallel to the sample surface.

Heme oxygenase-1 regulates the JNK signaling pathway through the MLK3-MKK7-JNK3 signaling module in brain ischemia injury.

Although previous researches indicated that heme oxygenase-1 (HO-1) plays a conspicuous role in neuronal injury induced by reperfusion following the brain ischemia, reasonable mechanisms for the role of HO-1 are not clear. In this work, we investigated whether HO-1 was involved in the regulation of the c-Jun N-terminal kinase (JNK) signaling pathway and neuronal cell injury induced by the brain ischemia followed by reperfusion. Cobaltic protoporphyrin (CoPP), an activator of HO-1, was administrated to induce the overexpression of HO-1 by intracerebroventricular infusion 20 min before ischemia.

A novel one-dimensional complex: catena-poly[[manganese(III)-di-mu-2-[(2-hydroxyethyl)iminomethyl]phenolato-kappa2O1,N:kappaO2;kappaO2:kappa2O1] chloride].

In the title one-dimensional complex, [[Mn(III)(C9H10NO2)2]Cl]n, the Schiff base ligand 2-[(2-hydroxyethyl)iminomethyl]phenolate (Hsae-) functions as both a bridging and a chelating ligand. The Mn(III) ion is six-coordinated by two N and four O atoms from four different Hsae- ligands, yielding a distorted MnO4N2 octahedral environment. Each [Mn(III)(Hsae)2]+ cationic unit has the Mn atom on an inversion centre and each [Mn(III)(Hsae)2]+ cation lies about another inversion centre.

[Spectral analysis of the structure of 1, 1'-and 1, 2'-dinaphthyl methanone].

The structure of 1, 1'-and 1, 2'-dinaphthyl methanone synthesized by the reaction of naphthalene with oxalyl chloride in the presence of AlCl3 were studied by using UV and FTIR in this paper. The analysis results showed that the difference of structures (symmetry) of 1,1'-and 1, 2'-dinaphthyl methanone were represented on the obvious difference of the spectra of UV and FTIR.