Publications by authors named "Zhi-Long Zheng"
DL-3-n-Butylphthalide (DL-NBP), a small molecular compound extracted from the seeds of Apium graveolens Linn (Chinese celery), has been shown to exert neuroprotective effects due to its anti-inflammatory, anti-oxidative and anti-apoptotic activities. DL-NBP not only protects against ischemic cerebral injury, but also ameliorates vascular cognitive impairment in dementia patients including AD and PD. In the current study, we investigated whether and how DL-NBP exerted a neuroprotective effect against diabetes-associated cognitive decline (DACD) in db/db mice, a model of type-2 diabetes.
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- The blood-spinal cord barrier is crucial for recovery after spinal cord injuries, yet its impact on neurovascular units is often overlooked in research.
- In experiments using mouse models, administration of platelet-derived growth factor reduced neuronal damage, improved locomotor function, and enhanced collagen synthesis while limiting harmful astrocyte proliferation and autophagy-related apoptosis.
- In vitro studies revealed that platelet-derived growth factor positively affects endothelial cells related to the blood-spinal cord barrier by reducing autophagy, and its benefits can be negated by using an autophagy inhibitor prior to injury.