Publications by authors named "Zhi-Lin Pang"
Study Design: Animal studies OBJECTIVES: To evaluate the therapeutic effect of olfactory mucosa mesenchymal stem cell (OM-MSCs) transplantation in mice with spinal cord injury (SCI) and to explore the mechanism by which OM-MSCs inhibit neuroinflammation and improve SCI.
Setting: Xiangya Hospital, Central South University; Affiliated Hospital of Guangdong Medical University.
Methods: Mice (C57BL/6, female, 6-week-old) were randomly divided into sham, SCI, and SCI + OM-MSC groups.
Article Synopsis
- Alzheimer's disease (AD) not only affects cognitive functions but also leads to changes in bone metabolism, resulting in lower bone density and strength in affected individuals.
- Recent research on AD mice showed that targeting specific autophagy receptors, Optineurin (OPTN) and Sequestosome 1 (SQSTM1), improved bone health and reduced amyloid beta (Aβ) deposits in bone tissue.
- This study highlights the potential of targeting autophagy as a dual therapeutic strategy to address both AD and osteoporosis, suggesting that Aβ deposition may link the two conditions.
Background: Amyotrophic lateral sclerosis (ALS) is irreversible and fatal within 3-5 years, with limited options for treatment. It is imperative to develop a symptom-based treatment that may increase the survival of ALS patients and improve their quality of life. Inflammation status, especially elevated interleukin 1β (IL1β), has been reported to play a critical role in ALS progression.
View Article and Find Full Text PDFAlzheimer's disease (AD) is a common neurodegenerative disease that contributes to 60-70% of dementia in elderly people and is currently incurable. Current treatments only relieve the symptoms of AD and slow its progression. Achieving effective neural regeneration to ameliorate cognitive impairment is a major challenge in the treatment of AD.
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